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Here, skeletally mature C57Bl6 mice were subjected to either rapid-onset non-surgical mechanical rupture of the anterior cruciate ligament (ACL) or to surgical destabilisation of the medial meniscus (DMM). Transcriptome profiling of micro-dissected cartilage at day\u00a07 or day\u00a042 following ACL or DMM procedure, respectively, showed that the two models were comparable and highly correlative. Gene ontology (GO) enrichment analysis identified similarly enriched pathways that were overrepresented by anabolic terms. To address the transcriptome changes more completely in the ACL model, we also performed small RNA sequencing, describing the first microRNA profile of this model. miR-199-5p was amongst the most abundant, yet differentially expressed, microRNAs, and its inhibition in primary human chondrocytes led to a transcriptome response that was comparable to that observed in both human \u2018OA damaged vs intact cartilage\u2019 and murine DMM cartilage datasets. We also experimentally verified CELSR1, GIT1, ECE1 and SOS2 as novel miR-199-5p targets. Together, these data support the use of the ACL rupture model as a non-invasive companion to the DMM model.<\/jats:p>","DOI":"10.1242\/dmm.050583","type":"journal-article","created":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T07:03:59Z","timestamp":1727161439000},"source":"Crossref","is-referenced-by-count":8,"title":["Comparative transcriptomic analysis of articular cartilage of post-traumatic osteoarthritis models"],"prefix":"10.1242","volume":"17","author":[{"given":"Sophie J.","family":"Gilbert","sequence":"first","affiliation":[{"name":"Biomechanics and Bioengineering Research Centre Versus Arthritis, Biomedicine Division, School of Biosciences, The Sir Martin Evans Building, Cardiff University 1 , Cardiff CF10 3AX, Wales ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2255-6459","authenticated-orcid":false,"given":"Jamie","family":"Soul","sequence":"additional","affiliation":[{"name":"Biosciences Institute, Newcastle University, Centre for Life, Central Parkway, Newcastle upon Tyne 2 NE1 3BZ ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Hao","sequence":"additional","affiliation":[{"name":"Biosciences Institute, Newcastle University, Centre for Life, Central Parkway, Newcastle upon Tyne 2 NE1 3BZ ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Lin","sequence":"additional","affiliation":[{"name":"Biosciences Institute, Newcastle University, Centre for Life, Central Parkway, Newcastle upon Tyne 2 NE1 3BZ ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna A.","family":"Pir\u00f3g","sequence":"additional","affiliation":[{"name":"Biosciences Institute, Newcastle University, Centre for Life, Central Parkway, Newcastle upon Tyne 2 NE1 3BZ ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6128-9560","authenticated-orcid":false,"given":"Jonathan","family":"Coxhead","sequence":"additional","affiliation":[{"name":"Biosciences Institute, Newcastle University, Centre for Life, Central Parkway, Newcastle upon Tyne 2 NE1 3BZ ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krutik","family":"Patel","sequence":"additional","affiliation":[{"name":"Biosciences Institute, Newcastle University, Centre for Life, Central Parkway, Newcastle upon Tyne 2 NE1 3BZ ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matt J.","family":"Barter","sequence":"additional","affiliation":[{"name":"Biosciences Institute, Newcastle University, Centre for Life, Central Parkway, Newcastle upon Tyne 2 NE1 3BZ ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7078-6745","authenticated-orcid":false,"given":"David A.","family":"Young","sequence":"additional","affiliation":[{"name":"Biosciences Institute, Newcastle University, Centre for Life, Central Parkway, Newcastle upon Tyne 2 NE1 3BZ ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8944-4254","authenticated-orcid":false,"given":"Emma J.","family":"Blain","sequence":"additional","affiliation":[{"name":"Biomechanics and Bioengineering Research Centre Versus Arthritis, Biomedicine Division, School of Biosciences, The Sir Martin Evans Building, Cardiff University 1 , Cardiff CF10 3AX, Wales ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2024,10,21]]},"reference":[{"key":"2024102107085655500_DMM050583C1","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1136\/annrheumdis-2011-200519","article-title":"MicroRNA-199a* regulates the expression of cyclooxygenase-2 in human chondrocytes","volume":"71","author":"Akhtar","year":"2012","journal-title":"Ann. 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