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Studies exploring adaptations of placentae that support the development of genetically small fetuses are lacking. Here, using a mouse model of impaired fetal growth, achieved by deleting insulin-like growth factor 2 (Igf2) in the epiblast, we assessed placental nutrient transfer and umbilical artery (UA) blood flow during late gestation. At embryonic day (E) 15.5, we observed a decline in the trans-placental flux of glucose and system A amino acids (by using 3H-MeG and 14C-MeAIB), proportionate to the diminished fetal size, whereas UA blood flow was normal. However, at E18.5, the trans-placental flux of both tracers was disproportionately decreased and accompanied by blunted UA blood flow. Feto-placental growth and nutrient transfer were more impaired in female conceptuses. Thus, reducing the fetal genetic demand for growth impairs the adaptations in placental blood flow and nutrient transport that normally support the fast fetal growth during late gestation. These findings have important implications for our understanding of the pathophysiology of pregnancies afflicted by fetal growth restriction.<\/jats:p>","DOI":"10.1242\/dmm.050719","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T12:47:32Z","timestamp":1724935652000},"source":"Crossref","is-referenced-by-count":5,"title":["A genetically small fetus impairs placental adaptations near term"],"prefix":"10.1242","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5674-4269","authenticated-orcid":false,"given":"Ionel","family":"Sandovici","sequence":"first","affiliation":[{"name":"National Institute for Health Research Cambridge Biomedical Research Centre 1 Department of Obstetrics and Gynaecology and , Cambridge CB2 0SW , UK"},{"name":"Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge 2 , Cambridge CB2 0QQ , UK"},{"name":"Centre for Trophoblast Research 3 , Department of Physiology, Development and Neuroscience , , Cambridge CB2 3EG , UK"},{"name":"University of Cambridge 3 , Department of Physiology, Development and Neuroscience , , Cambridge CB2 3EG , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olatejumoye","family":"Knee","sequence":"additional","affiliation":[{"name":"National Institute for Health Research Cambridge Biomedical Research Centre 1 Department of Obstetrics and Gynaecology and , Cambridge CB2 0SW , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7886-0233","authenticated-orcid":false,"given":"Jorge","family":"Lopez-Tello","sequence":"additional","affiliation":[{"name":"Centre for Trophoblast Research 3 , Department of Physiology, Development and Neuroscience , , Cambridge CB2 3EG , UK"},{"name":"University of Cambridge 3 , Department of Physiology, Development and Neuroscience , , Cambridge CB2 3EG , UK"},{"name":"Universidad Aut\u00f3noma de Madrid 4 Department of Physiology, Faculty of Medicine , , Madrid 28029 , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3786-3929","authenticated-orcid":false,"given":"Norman","family":"Shreeve","sequence":"additional","affiliation":[{"name":"National Institute for Health Research Cambridge Biomedical Research Centre 1 Department of Obstetrics and Gynaecology and , Cambridge CB2 0SW , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3384-4467","authenticated-orcid":false,"given":"Abigail L.","family":"Fowden","sequence":"additional","affiliation":[{"name":"Centre for Trophoblast Research 3 , Department of Physiology, Development and Neuroscience , , Cambridge CB2 3EG , UK"},{"name":"University of Cambridge 3 , Department of Physiology, Development and Neuroscience , , Cambridge CB2 3EG , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4931-4233","authenticated-orcid":false,"given":"Amanda N.","family":"Sferruzzi-Perri","sequence":"additional","affiliation":[{"name":"Centre for Trophoblast Research 3 , Department of Physiology, Development and Neuroscience , , Cambridge CB2 3EG , UK"},{"name":"University of Cambridge 3 , Department of Physiology, Development and Neuroscience , , Cambridge CB2 3EG , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8976-1679","authenticated-orcid":false,"given":"Miguel","family":"Const\u00e2ncia","sequence":"additional","affiliation":[{"name":"National Institute for Health Research Cambridge Biomedical Research Centre 1 Department of Obstetrics and Gynaecology and , Cambridge CB2 0SW , UK"},{"name":"Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge 2 , Cambridge CB2 0QQ , UK"},{"name":"Centre for Trophoblast Research 3 , Department of Physiology, Development and Neuroscience , , Cambridge CB2 3EG , UK"},{"name":"University of Cambridge 3 , Department of Physiology, Development and Neuroscience , , Cambridge CB2 3EG , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2024,8,29]]},"reference":[{"key":"2024082912471372100_DMM050719C1","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1002\/dvdy.20320","article-title":"Delayed and disturbed morphogenesis of the umbilical blood vessels in insulin-like growth factor-II deficient conceptuses (Igf2m+\/p-)","volume":"233","author":"Ahmad","year":"2005","journal-title":"Dev. 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