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Axolotls, unlike humans, are capable of regenerating their lower jaws; however, the underlying mechanisms and their similarities to those in limb regeneration are unknown. In this work, we used morphological, histological and transcriptomic approaches to analyze the regeneration of lateral resection defects in the axolotl mandible. We found that this structure can regenerate all missing tissues in 90\u2005days through gap minimization, blastema formation and, finally, tissue growth, differentiation and integration. Moreover, transcriptomic comparisons of regenerating mandibles and limbs showed that they share molecular phases of regeneration, that these similarities peak during blastema stages and that mandible regeneration occurs at a slower pace. Altogether, our study demonstrates the existence of a shared regenerative program used in two different regenerating body structures with different embryonic origins in the axolotl and contributes to our understanding of the minimum requirements for a successful regeneration in vertebrates, bringing us closer to understand similar lesions in human mandibles.<\/jats:p>","DOI":"10.1242\/dmm.050743","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T05:47:01Z","timestamp":1724910421000},"source":"Crossref","is-referenced-by-count":6,"title":["Axolotl mandible regeneration occurs through mechanical gap closure and a shared regenerative program with the limb"],"prefix":"10.1242","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8257-2728","authenticated-orcid":false,"given":"Julia","family":"Kramer","sequence":"first","affiliation":[{"name":"University Hospital Carl Gustav Carus Dresden, Technische Universit\u00e4t Dresden 1 Clinic of Oral and Maxillofacial Surgery , , 01307 Dresden ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3537-0453","authenticated-orcid":false,"given":"Rita","family":"Aires","sequence":"additional","affiliation":[{"name":"Center for Healthy Aging, University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden 2 Department of Internal Medicine III , , 01307 Dresden ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2429-3253","authenticated-orcid":false,"given":"Sean D.","family":"Keeley","sequence":"additional","affiliation":[{"name":"Center for Healthy Aging, University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden 2 Department of Internal Medicine III , , 01307 Dresden ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9689-3020","authenticated-orcid":false,"given":"Tom Alexander","family":"Schr\u00f6der","sequence":"additional","affiliation":[{"name":"University Hospital Carl Gustav Carus Dresden, Technische Universit\u00e4t Dresden 1 Clinic of Oral and Maxillofacial Surgery , , 01307 Dresden ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7536-0885","authenticated-orcid":false,"given":"G\u00fcnter","family":"Lauer","sequence":"additional","affiliation":[{"name":"University Hospital Carl Gustav Carus Dresden, Technische Universit\u00e4t Dresden 1 Clinic of Oral and Maxillofacial Surgery , , 01307 Dresden ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1802-5145","authenticated-orcid":false,"given":"Tatiana","family":"Sandoval-Guzm\u00e1n","sequence":"additional","affiliation":[{"name":"Center for Healthy Aging, University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden 2 Department of Internal Medicine III , , 01307 Dresden ,","place":["Germany"]},{"name":"Paul Langerhans Institute Dresden, Helmholtz Centre Munich, University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden 3 , 01307 Dresden ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2024,9,27]]},"reference":[{"key":"2024100207262690100_DMM050743C1","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1007\/978-3-319-08831-0_66","article-title":"Basics of self-regeneration","author":"Aires","year":"2020","journal-title":"Cell Engineering and Regeneration"},{"key":"2024100207262690100_DMM050743C2","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1590\/S1678-77572010000100005","article-title":"Mandibular fractures: a comparative analysis between young and adult patients in the southeast region of Turkey","volume":"18","author":"Atilgan","year":"2010","journal-title":"J. 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