{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T09:19:08Z","timestamp":1782897548582,"version":"3.54.5"},"reference-count":77,"publisher":"The Company of Biologists","issue":"9","license":[{"start":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T00:00:00Z","timestamp":1726444800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"National Cancer Institute"},{"name":"NCI","award":["R01-CA085862"],"award-info":[{"award-number":["R01-CA085862"]}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000060","name":"NIAID","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007015","name":"University of Wisconsin-Madison","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007015","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>The microbiome can influence cancer development and progression. However, less is known about the role of the skin microbiota in melanoma. Here, we took advantage of a zebrafish melanoma model to probe the effects of Staphylococcus aureus on melanoma invasion. We found that S. aureus produces factors that enhance melanoma invasion and dissemination in zebrafish larvae. We used a published in vitro 3D cluster formation assay that correlates increased clustering with tumor invasion. S. aureus supernatant increased clustering of melanoma cells and was abrogated by a Rho-Kinase inhibitor, implicating a role for Rho-GTPases. The melanoma clustering response was specific to S. aureus but not to other staphylococcal species, including S. epidermidis. Our findings suggest that S. aureus promotes melanoma clustering and invasion via lipids generated by the lipase Sal2 (officially known as GehB). Taken together, these findings suggest that specific bacterial products mediate melanoma invasive migration in zebrafish.<\/jats:p>","DOI":"10.1242\/dmm.050770","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T08:23:38Z","timestamp":1726475018000},"source":"Crossref","is-referenced-by-count":14,"title":["<i>Staphylococcus aureus<\/i> lipid factors modulate melanoma cell clustering and invasion"],"prefix":"10.1242","volume":"17","author":[{"given":"Morgan A.","family":"Giese","sequence":"first","affiliation":[{"name":"University of Wisconsin-Madison, School of Medicine and Public Health 1 Department of Medical Microbiology and Immunology , , Madison, WI 53706 ,","place":["USA"]},{"name":"University of Wisconsin-Madison 2 Cellular and Molecular Biology Graduate Program , , Madison, WI 53706 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gayathri","family":"Ramakrishnan","sequence":"additional","affiliation":[{"name":"University of Wisconsin-Madison, School of Medicine and Public Health 1 Department of Medical Microbiology and Immunology , , Madison, WI 53706 ,","place":["USA"]},{"name":"University of Wisconsin-Madison 3 Cancer Biology Graduate Program , , Madison, WI 53706 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura H.","family":"Steenberge","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Wisconsin-Madison 4 , Madison, WI ,","place":["USA"]},{"name":"University of Wisconsin School of Medicine and Public Health 5 , Madison, Wisconsin ,","place":["USA"]},{"name":"Morgridge Institute for Research 6 , Madison, Wisconsin ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome X.","family":"Dovan","sequence":"additional","affiliation":[{"name":"University of Wisconsin Medical Scientist Training Program (MSTP) Summer Scholars, University of Wisconsin-Madison 7 , Madison, WI 53706 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9367-794X","authenticated-orcid":false,"given":"John-Demian","family":"Sauer","sequence":"additional","affiliation":[{"name":"University of Wisconsin-Madison, School of Medicine and Public Health 1 Department of Medical Microbiology and Immunology , , Madison, WI 53706 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7940-6254","authenticated-orcid":false,"given":"Anna","family":"Huttenlocher","sequence":"additional","affiliation":[{"name":"University of Wisconsin-Madison, School of Medicine and Public Health 1 Department of Medical Microbiology and Immunology , , Madison, WI 53706 ,","place":["USA"]},{"name":"University of Wisconsin-Madison 8 Department of Pediatrics , , Madison, WI 53706 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2024,9,16]]},"reference":[{"key":"2025032807562592200_DMM050770C1","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","article-title":"Basic local alignment search tool","volume":"215","author":"Altschul","year":"1990","journal-title":"J. Mol. Biol."},{"key":"2025032807562592200_DMM050770C2","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1002\/cm.20472","article-title":"Rho-kinase\/ROCK: a key regulator of the cytoskeleton and cell polarity","volume":"67","author":"Amano","year":"2010","journal-title":"Cytoskeleton (Hoboken)"},{"key":"2025032807562592200_DMM050770C3","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1126\/science.1224820","article-title":"Intestinal inflammation targets cancer-inducing activity of the microbiota","volume":"338","author":"Arthur","year":"2012","journal-title":"Science"},{"key":"2025032807562592200_DMM050770C4","doi-asserted-by":"publisher","first-page":"a037077","DOI":"10.1101\/cshperspect.a037077","article-title":"Zebrafish in vivo models of cancer and metastasis","volume":"10","author":"Astell","year":"2020","journal-title":"Cold Spring Harb. Perspect Med."},{"key":"2025032807562592200_DMM050770C5","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1128\/JB.01000-07","article-title":"Genome sequence of Staphylococcus aureus strain Newman and comparative analysis of staphylococcal genomes: polymorphism and evolution of two major pathogenicity islands","volume":"190","author":"Baba","year":"2008","journal-title":"J. Bacteriol."},{"key":"2025032807562592200_DMM050770C6","doi-asserted-by":"publisher","first-page":"6199","DOI":"10.1200\/JCO.2009.23.4799","article-title":"Final version of 2009 AJCC melanoma staging and classification","volume":"27","author":"Balch","year":"2009","journal-title":"J. Clin. Oncol."},{"key":"2025032807562592200_DMM050770C7","doi-asserted-by":"publisher","first-page":"3801","DOI":"10.1242\/jcs.206128","article-title":"Live imaging reveals distinct modes of neutrophil and macrophage migration within interstitial tissues","volume":"130","author":"Barros-Becker","year":"2017","journal-title":"J. Cell Sci."},{"key":"2025032807562592200_DMM050770C9","doi-asserted-by":"publisher","first-page":"135","DOI":"10.3389\/fimmu.2014.00135","article-title":"Toll-like receptors and skin cancer","volume":"5","author":"Burns","year":"2014","journal-title":"Front. Immunol."},{"key":"2025032807562592200_DMM050770C10","doi-asserted-by":"publisher","first-page":"4044","DOI":"10.1128\/JB.02044-14","article-title":"Role of lipase from community-associated methicillin-resistant Staphylococcus aureus strain USA300 in hydrolyzing triglycerides into growth-inhibitory free fatty acids","volume":"196","author":"Cadieux","year":"2014","journal-title":"J. Bacteriol."},{"key":"2025032807562592200_DMM050770C11","doi-asserted-by":"publisher","first-page":"2808","DOI":"10.1016\/j.devcel.2021.08.018","article-title":"Cooperation between melanoma cell states promotes metastasis through heterotypic cluster formation","volume":"56","author":"Campbell","year":"2021","journal-title":"Dev. Cell"},{"key":"2025032807562592200_DMM050770C12","doi-asserted-by":"publisher","first-page":"eaba9157","DOI":"10.1126\/scisignal.aba9157","article-title":"Fusobacterium nucleatum host-cell binding and invasion induces IL-8 and CXCL1 secretion that drives colorectal cancer cell migration","volume":"13","author":"Casasanta","year":"2020","journal-title":"Sci. Signal."},{"key":"2025032807562592200_DMM050770C13","doi-asserted-by":"publisher","first-page":"3764","DOI":"10.1073\/pnas.1817248116","article-title":"3rd, Bacterial lipolysis of immune-activating ligands promotes evasion of innate defenses","volume":"116","author":"Chen","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025032807562592200_DMM050770C15","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/j.immuni.2019.09.014","article-title":"Metabolite-sensing receptor Ffar2 regulates colonic group 3 innate lymphoid cells and gut immunity","volume":"51","author":"Chun","year":"2019","journal-title":"Immunity"},{"key":"2025032807562592200_DMM050770C16","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1038\/nature23874","article-title":"Commensal bacteria make GPCR ligands that mimic human signalling molecules","volume":"549","author":"Cohen","year":"2017","journal-title":"Nature"},{"key":"2025032807562592200_DMM050770C17","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1038\/nrclinonc.2015.105","article-title":"Inflammation and cancer: advances and new agents","volume":"12","author":"Crusz","year":"2015","journal-title":"Nat Rev Clin Oncol"},{"key":"2025032807562592200_DMM050770C18","doi-asserted-by":"publisher","first-page":"812774","DOI":"10.3389\/fimmu.2022.812774","article-title":"Toll-Like Receptor Signaling and Its Role in Cell-Mediated Immunity","volume":"13","author":"Duan","year":"2022","journal-title":"Front Immunol"},{"key":"2025032807562592200_DMM050770C22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10616-010-9263-3","article-title":"Albumin and mammalian cell culture: implications for biotechnology applications","volume":"62","author":"Francis","year":"2010","journal-title":"Cytotechnology"},{"key":"2025032807562592200_DMM050770C23","doi-asserted-by":"publisher","first-page":"10646","DOI":"10.1073\/pnas.0504927102","article-title":"Activation of beta-catenin by carcinogenic Helicobacter pylori","volume":"102","author":"Franco","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025032807562592200_DMM050770C24","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1126\/science.aaa4972","article-title":"Cancer and the microbiota","volume":"348","author":"Garrett","year":"2015","journal-title":"Science"},{"key":"2025032807562592200_DMM050770C25","doi-asserted-by":"publisher","first-page":"2159","DOI":"10.1182\/blood-2018-11-844548","article-title":"Neutrophil plasticity in the tumor microenvironment","volume":"133","author":"Giese","year":"2019","journal-title":"Blood Rev"},{"key":"2025032807562592200_DMM050770C26","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1101\/gad.314617.118","article-title":"Roles of the immune system in cancer: from tumor initiation to metastatic progression","volume":"32","author":"Gonzalez","year":"2018","journal-title":"Genes Dev."},{"key":"2025032807562592200_DMM050770C27","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1126\/science.aan4236","article-title":"Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients","volume":"359","author":"Gopalakrishnan","year":"2018","journal-title":"Science"},{"key":"2025032807562592200_DMM050770C28","doi-asserted-by":"publisher","first-page":"1623","DOI":"10.1007\/s00018-018-2749-4","article-title":"Molecular recognition of microbial lipid-based antigens by T cells","volume":"75","author":"Gras","year":"2018","journal-title":"Cell. Mol. Life Sci."},{"key":"2025032807562592200_DMM050770C29","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/978-1-4614-0106-3_4","article-title":"Interaction of the microbiome with the innate immune response in chronic wounds","volume":"946","author":"Grice","year":"2012","journal-title":"Adv. Exp. Med. Biol."},{"key":"2025032807562592200_DMM050770C30","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1158\/2159-8290.CD-21-1059","article-title":"Hallmarks of cancer: new dimensions","volume":"12","author":"Hanahan","year":"2022","journal-title":"Cancer Discov"},{"key":"2025032807562592200_DMM050770C31","doi-asserted-by":"publisher","first-page":"e00115-20","DOI":"10.1128\/JB.00115-20","article-title":"A novel growth-based selection strategy identifies new constitutively active variants of the major virulence regulator PrfA in listeria monocytogenes","volume":"202","author":"Hansen","year":"2020","journal-title":"J. Bacteriol."},{"key":"2025032807562592200_DMM050770C32","doi-asserted-by":"publisher","first-page":"4272","DOI":"10.1158\/0008-5472.CAN-14-3319","article-title":"A quantitative system for studying metastasis using transparent zebrafish","volume":"75","author":"Heilmann","year":"2015","journal-title":"Cancer Res."},{"key":"2025032807562592200_DMM050770C33","doi-asserted-by":"publisher","first-page":"e00339-20","DOI":"10.1128\/mSphere.00339-20","article-title":"Lipidomic and ultrastructural characterization of the cell envelope of staphylococcus aureus grown in the presence of human serum","volume":"5","author":"Hines","year":"2020","journal-title":"mSphere"},{"key":"2025032807562592200_DMM050770C34","doi-asserted-by":"publisher","first-page":"5932","DOI":"10.1038\/ncomms6932","article-title":"Innate sensing of microbial products promotes wound-induced skin cancer","volume":"6","author":"Hoste","year":"2015","journal-title":"Nat. Commun."},{"key":"2025032807562592200_DMM050770C35","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1089\/zeb.2016.1323","article-title":"zWEDGI: wounding and entrapment device for imaging live zebrafish larvae","volume":"14","author":"Huemer","year":"2017","journal-title":"Zebrafish"},{"key":"2025032807562592200_DMM050770C36","first-page":"1","article-title":"Biological agents","volume":"100","author":"IARC Working Group on the Evaluation of Carcinogenic Risks to Humans","year":"2012","journal-title":"IARC Monogr. Eval. Carcinog. Risks Hum."},{"key":"2025032807562592200_DMM050770C37","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1126\/science.1240527","article-title":"Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment","volume":"342","author":"Iida","year":"2013","journal-title":"Science"},{"key":"2025032807562592200_DMM050770C38","doi-asserted-by":"publisher","first-page":"4279","DOI":"10.1038\/onc.2011.595","article-title":"The Rho\/ROCK pathway for lysophosphatidic acid-induced proteolytic enzyme expression and ovarian cancer cell invasion","volume":"31","author":"Jeong","year":"2012","journal-title":"Oncogene"},{"key":"2025032807562592200_DMM050770C39","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1038\/s41586-021-03368-8","article-title":"Identification of bacteria-derived HLA-bound peptides in melanoma","volume":"592","author":"Kalaora","year":"2021","journal-title":"Nature"},{"key":"2025032807562592200_DMM050770C40","doi-asserted-by":"publisher","first-page":"818893","DOI":"10.3389\/fimmu.2022.818893","article-title":"Cell type-specific transcriptome profiling reveals a role for Thioredoxin during tumor initiation","volume":"13","author":"Korte","year":"2022","journal-title":"Front Immunol"},{"key":"2025032807562592200_DMM050770C41","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1158\/1055-9965.EPI-08-0905","article-title":"Staphylococcus aureus and squamous cell carcinoma of the skin","volume":"18","author":"Kullander","year":"2009","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"2025032807562592200_DMM050770C42","doi-asserted-by":"publisher","first-page":"1893","DOI":"10.3390\/cancers15061893","article-title":"Current understanding of microbiomes in cancer metastasis","volume":"15","author":"Liu","year":"2023","journal-title":"Cancers (Basel)"},{"key":"2025032807562592200_DMM050770C43","doi-asserted-by":"publisher","first-page":"e105","DOI":"10.1038\/oncsis.2014.20","article-title":"Enteric bacterial protein AvrA promotes colonic tumorigenesis and activates colonic beta-catenin signaling pathway","volume":"3","author":"Lu","year":"2014","journal-title":"Oncogenesis"},{"key":"2025032807562592200_DMM050770C44","doi-asserted-by":"publisher","first-page":"541","DOI":"10.3390\/cancers12030541","article-title":"Molecular profiling of keratinocyte skin tumors links staphylococcus aureus overabundance and increased human beta-defensin-2 expression to growth promotion of squamous cell carcinoma","volume":"12","author":"Madhusudhan","year":"2020","journal-title":"Cancers (Basel)"},{"key":"2025032807562592200_DMM050770C45","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1186\/s12866-022-02458-5","article-title":"Dysbiosis of skin microbiome and gut microbiome in melanoma progression","volume":"22","author":"Mekadim","year":"2022","journal-title":"BMC Microbiol."},{"key":"2025032807562592200_DMM050770C47","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1186\/1471-2105-7-123","article-title":"Detecting outliers when fitting data with nonlinear regression - a new method based on robust nonlinear regression and the false discovery rate","volume":"7","author":"Motulsky","year":"2006","journal-title":"BMC Bioinformatics"},{"key":"2025032807562592200_DMM050770C48","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1038\/nature12655","article-title":"Staphylococcus delta-toxin induces allergic skin disease by activating mast cells","volume":"503","author":"Nakamura","year":"2013","journal-title":"Nature"},{"key":"2025032807562592200_DMM050770C50","doi-asserted-by":"publisher","first-page":"3259","DOI":"10.1038\/s41467-020-16967-2","article-title":"Breast cancer colonization by Fusobacterium nucleatum accelerates tumor growth and metastatic progression","volume":"11","author":"Parhi","year":"2020","journal-title":"Nat. Commun."},{"key":"2025032807562592200_DMM050770C51","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1016\/j.ccell.2021.01.011","article-title":"Melanoma models for the next generation of therapies","volume":"39","author":"Patton","year":"2021","journal-title":"Cancer Cell"},{"key":"2025032807562592200_DMM050770C52","doi-asserted-by":"publisher","first-page":"100773","DOI":"10.1016\/j.tranon.2020.100773","article-title":"Epithelial-mesenchymal transition in cancer: a historical overview","volume":"13","author":"Ribatti","year":"2020","journal-title":"Transl Oncol"},{"key":"2025032807562592200_DMM050770C53","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/j.devcel.2017.11.003","article-title":"Macrophage-dependent cytoplasmic transfer during melanoma invasion in vivo","volume":"43","author":"Roh-Johnson","year":"2017","journal-title":"Dev. Cell"},{"key":"2025032807562592200_DMM050770C54","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1016\/S0300-9084(00)01180-9","article-title":"Staphylococcal lipases: biochemical and molecular characterization","volume":"82","author":"Rosenstein","year":"2000","journal-title":"Biochimie"},{"key":"2025032807562592200_DMM050770C55","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.chom.2013.07.012","article-title":"Fusobacterium nucleatum promotes colorectal carcinogenesis by modulating E-cadherin\/beta-catenin signaling via its FadA adhesin","volume":"14","author":"Rubinstein","year":"2013","journal-title":"Cell Host Microbe"},{"key":"2025032807562592200_DMM050770C56","doi-asserted-by":"publisher","first-page":"001315","DOI":"10.1099\/mic.0.001315","article-title":"Membrane lipids from gut microbiome-associated bacteria as structural and signalling molecules","volume":"169","author":"Ryan","year":"2023","journal-title":"Microbiology (Read.)"},{"key":"2025032807562592200_DMM050770C57","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1684\/ejd.2015.2696","article-title":"Skin microbiome in melanomas and melanocytic nevi","volume":"26","author":"Salava","year":"2016","journal-title":"Eur. J. Dermatol."},{"key":"2025032807562592200_DMM050770C58","doi-asserted-by":"publisher","first-page":"2386","DOI":"10.3390\/microorganisms11102386","article-title":"Role of the microbiota in skin neoplasms: new therapeutic horizons","volume":"11","author":"Savoia","year":"2023","journal-title":"Microorganisms"},{"key":"2025032807562592200_DMM050770C59","doi-asserted-by":"publisher","first-page":"e1011152","DOI":"10.1371\/journal.ppat.1011152","article-title":"Aspergillus fumigatus transcription factor ZfpA regulates hyphal development and alters susceptibility to antifungals and neutrophil killing during infection","volume":"19","author":"Schoen","year":"2023","journal-title":"PLoS Pathog."},{"key":"2025032807562592200_DMM050770C60","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1001\/jama.2022.24075","article-title":"Surgical site infection prevention: a review","volume":"329","author":"Seidelman","year":"2023","journal-title":"JAMA"},{"key":"2025032807562592200_DMM050770C61","doi-asserted-by":"publisher","first-page":"eabc4552","DOI":"10.1126\/science.abc4552","article-title":"The microbiome and human cancer","volume":"371","author":"Sepich-Poore","year":"2021","journal-title":"Science"},{"key":"2025032807562592200_DMM050770C62","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1517\/14728221003652471","article-title":"Targeting CXCR1\/CXCR2 receptor antagonism in malignant melanoma","volume":"14","author":"Sharma","year":"2010","journal-title":"Expert Opin Ther. Targets"},{"key":"2025032807562592200_DMM050770C63","doi-asserted-by":"publisher","first-page":"3760","DOI":"10.1210\/en.2016-1297","article-title":"Endocrine response phenotypes are altered by charcoal-stripped serum variability","volume":"157","author":"Sikora","year":"2016","journal-title":"Endocrinology"},{"key":"2025032807562592200_DMM050770C64","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1002\/JLB.4RI0418-151R","article-title":"The interplay between neutrophils and microbiota in cancer","volume":"104","author":"Smith","year":"2018","journal-title":"J. Leukoc. Biol"},{"key":"2025032807562592200_DMM050770C65","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1093\/femsre\/fuv008","article-title":"Bacterial membrane lipids: diversity in structures and pathways","volume":"40","author":"Sohlenkamp","year":"2016","journal-title":"FEMS Microbiol. Rev."},{"key":"2025032807562592200_DMM050770C66","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1080\/1040841X.2020.1794792","article-title":"Non-melanoma skin cancer: news from microbiota research","volume":"46","author":"Squarzanti","year":"2020","journal-title":"Crit. Rev. Microbiol."},{"key":"2025032807562592200_DMM050770C67","doi-asserted-by":"publisher","first-page":"2411","DOI":"10.1128\/IAI.73.4.2411-2423.2005","article-title":"Staphylococcus aureus deficient in lipidation of prelipoproteins is attenuated in growth and immune activation","volume":"73","author":"Stoll","year":"2005","journal-title":"Infect. Immun."},{"key":"2025032807562592200_DMM050770C68","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1038\/s41396-023-01483-0","article-title":"Potential effects of gut microbiota on host cancers: focus on immunity, DNA damage, cellular pathways, and anticancer therapy","volume":"17","author":"Sun","year":"2023","journal-title":"ISME J."},{"key":"2025032807562592200_DMM050770C69","doi-asserted-by":"publisher","first-page":"e00695-20","DOI":"10.1128\/IAI.00695-20","article-title":"Living in your skin: microbes, molecules, and mechanisms","volume":"89","author":"Swaney","year":"2021","journal-title":"Infect. Immun."},{"key":"2025032807562592200_DMM050770C70","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/B978-0-12-800100-4.00003-9","article-title":"The role of short-chain fatty acids in health and disease","volume":"121","author":"Tan","year":"2014","journal-title":"Adv. Immunol."},{"key":"2025032807562592200_DMM050770C71","doi-asserted-by":"publisher","first-page":"300","DOI":"10.2133\/dmpk.24.300","article-title":"Albumin as fatty acid transporter","volume":"24","author":"van der Vusse","year":"2009","journal-title":"Drug Metab. Pharmacokinet"},{"key":"2025032807562592200_DMM050770C72","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1007\/s10585-008-9156-4","article-title":"The upstream components of the Wnt signalling pathway in the dynamic EMT and MET associated with colorectal cancer progression","volume":"25","author":"Vincan","year":"2008","journal-title":"Clin. Exp. Metastasis"},{"key":"2025032807562592200_DMM050770C73","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1111\/cmi.12536","article-title":"Macrophages mediate flagellin induced inflammasome activation and host defense in zebrafish","volume":"18","author":"Vincent","year":"2016","journal-title":"Cell. Microbiol."},{"key":"2025032807562592200_DMM050770C74","doi-asserted-by":"publisher","first-page":"8056","DOI":"10.1021\/bi00487a010","article-title":"Phosphatidylinositol-specific phospholipase C from Bacillus cereus combines intrinsic phosphotransferase and cyclic phosphodiesterase activities: a 31P NMR study","volume":"29","author":"Volwerk","year":"1990","journal-title":"Biochemistry"},{"key":"2025032807562592200_DMM050770C75","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/0006-291X(90)91449-3","article-title":"Induction of haptotactic migration of melanoma cells by neutrophil activating protein\/interleukin-8","volume":"169","author":"Wang","year":"1990","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2025032807562592200_DMM050770C76","doi-asserted-by":"publisher","first-page":"e69703","DOI":"10.7554\/eLife.69703","article-title":"Shifting the focus of zebrafish toward a model of the tumor microenvironment","volume":"11","author":"Weiss","year":"2022","journal-title":"Elife"},{"key":"2025032807562592200_DMM050770C77","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.stem.2007.11.002","article-title":"Transparent adult zebrafish as a tool for in vivo transplantation analysis","volume":"2","author":"White","year":"2008","journal-title":"Cell Stem Cell"},{"key":"2025032807562592200_DMM050770C78","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1128\/IAI.01168-13","article-title":"Phosphatidylinositol-specific phospholipase C contributes to survival of Staphylococcus aureus USA300 in human blood and neutrophils","volume":"82","author":"White","year":"2014","journal-title":"Infect. Immun."},{"key":"2025032807562592200_DMM050770C79","doi-asserted-by":"publisher","first-page":"2923","DOI":"10.1016\/j.celrep.2020.02.021","article-title":"Interplay of staphylococcal and host proteases promotes skin barrier disruption in netherton syndrome","volume":"30","author":"Williams","year":"2020","journal-title":"Cell Rep"},{"key":"2025032807562592200_DMM050770C80","doi-asserted-by":"publisher","first-page":"1813","DOI":"10.3390\/ijms23031813","article-title":"The human microbiota and skin cancer","volume":"23","author":"Woo","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"2025032807562592200_DMM050770C81","doi-asserted-by":"publisher","first-page":"e01432-18","DOI":"10.1128\/mBio.01432-18","article-title":"A natural history of actinic keratosis and cutaneous squamous cell carcinoma microbiomes","volume":"9","author":"Wood","year":"2018","journal-title":"mBio"},{"key":"2025032807562592200_DMM050770C83","first-page":"461","article-title":"The role of the cutaneous microbiome in skin cancer: lessons learned from the gut","volume":"14","author":"Yu","year":"2015","journal-title":"J. Drugs Dermatol."},{"key":"2025032807562592200_DMM050770C84","doi-asserted-by":"publisher","first-page":"R101","DOI":"10.1186\/gb-2012-13-11-r101","article-title":"Microbiome dynamics of human epidermis following skin barrier disruption","volume":"13","author":"Zeeuwen","year":"2012","journal-title":"Genome Biol."},{"key":"2025032807562592200_DMM050770C85","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1038\/s41422-020-0332-7","article-title":"Interaction between microbiota and immunity in health and disease","volume":"30","author":"Zheng","year":"2020","journal-title":"Cell Res."}],"container-title":["Disease Models &amp; Mechanisms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.biologists.com\/dmm\/article-pdf\/doi\/10.1242\/dmm.050770\/3566426\/dmm050770.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dmm\/article-pdf\/doi\/10.1242\/dmm.050770\/3566426\/dmm050770.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T12:03:55Z","timestamp":1743163435000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dmm\/article\/17\/9\/dmm050770\/362066\/Staphylococcus-aureus-lipid-factors-modulate"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,1]]},"references-count":77,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9,1]]}},"URL":"https:\/\/doi.org\/10.1242\/dmm.050770","relation":{},"ISSN":["1754-8403","1754-8411"],"issn-type":[{"value":"1754-8403","type":"print"},{"value":"1754-8411","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,1]]},"article-number":"dmm050770"}}