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Many of these models use highly mitotically active Drosophila tissues. Few Drosophila tumorigenesis models use adult tissues, when most cells are terminally differentiated and postmitotic. The Drosophila accessory glands are prostate-like tissues, and a model for prostate tumorigenesis using this tissue has been explored. In this prior model, oncogenic signaling was induced during the proliferative stages of accessory gland development, raising the question of how oncogenic activity impacts the terminally differentiated, postmitotic adult tissue. Here, we show that oncogenic signaling in the adult Drosophila accessory gland leads to activation of a conserved pro-tumorigenic program, similar to that of mitotic tissues, but in the absence of proliferation. In our experiments, oncogenic signaling in the adult gland led to tissue hypertrophy with nuclear anaplasia, in part through endoreduplication. Oncogene-induced gene expression changes in the adult Drosophila prostate-like model overlapped with those in polyploid prostate cancer cells after chemotherapy, which potentially mediate tumor recurrence. Thus, the adult accessory glands provide a useful model for aspects of prostate cancer progression that lack cellular proliferation.<\/jats:p>","DOI":"10.1242\/dmm.052001","type":"journal-article","created":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T04:00:00Z","timestamp":1745985600000},"source":"Crossref","is-referenced-by-count":5,"title":["Oncogenic signaling in the\n                    <i>Drosophila<\/i>\n                    prostate-like accessory gland activates a pro-tumorigenic program in the absence of proliferation"],"prefix":"10.1242","volume":"18","author":[{"given":"S. Jaimian","family":"Church","sequence":"first","affiliation":[{"name":"University of Michigan 1 Molecular, Cellular and Developmental Biology , , Ann Arbor, MI 48109 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajai J.","family":"Pulianmackal","sequence":"additional","affiliation":[{"name":"University of Michigan 1 Molecular, Cellular and Developmental Biology , , Ann Arbor, MI 48109 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph A.","family":"Dixon","sequence":"additional","affiliation":[{"name":"University of Michigan 1 Molecular, Cellular and Developmental Biology , , Ann Arbor, MI 48109 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke V.","family":"Loftus","sequence":"additional","affiliation":[{"name":"Cancer Ecology Center, The Brady Urological Institute, Johns Hopkins University School of Medicine 2 , Baltimore, MD 21287 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5606-1262","authenticated-orcid":false,"given":"Sarah R.","family":"Amend","sequence":"additional","affiliation":[{"name":"Cancer Ecology Center, The Brady Urological Institute, Johns Hopkins University School of Medicine 2 , Baltimore, MD 21287 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Pienta","sequence":"additional","affiliation":[{"name":"Cancer Ecology Center, The Brady Urological Institute, Johns Hopkins University School of Medicine 2 , Baltimore, MD 21287 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank C.","family":"Cackowski","sequence":"additional","affiliation":[{"name":"Karmanos Cancer Institute and Wayne State University 3 , Department of Oncology, Detroit, MI 48201 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5064-0650","authenticated-orcid":false,"given":"Laura A.","family":"Buttitta","sequence":"additional","affiliation":[{"name":"University of Michigan 1 Molecular, Cellular and Developmental Biology , , Ann Arbor, MI 48109 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2025,4,30]]},"reference":[{"key":"2025050804120531700_DMM052001C1","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1038\/onc.2015.109","article-title":"The oncogene ERG: a key factor in prostate cancer","volume":"35","author":"Adamo","year":"2016","journal-title":"Oncogene"},{"key":"2025050804120531700_DMM052001C2","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.jinsphys.2006.12.003","article-title":"Seminal proteins but not sperm induce morphological changes in the Drosophila melanogaster female reproductive tract during sperm storage","volume":"53","author":"Adams","year":"2007","journal-title":"J. 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