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Prior studies revealed an increase in extracellular glutamate levels after evoking astrocytic SNARE-dependent exocytosis from cultured primary astrocytes from mutant huntingtin (mHTT)-expressing BACHD mice compared to control astrocytes, suggesting alterations in astrocytic SNARE-dependent exocytosis in HD. We used BACHD and dominant-negative (dn)SNARE mice to decrease SNARE-dependent exocytosis from astrocytes to determine whether reducing SNARE-dependent exocytosis from astrocytes could rescue neuropathological changes in vivo. We observed significant protection against striatal atrophy and no significant rescue of cortical atrophy in BACHD\/dnSNARE mice compared to BACHD mice. Amino acid transporters are important for modulating the levels of extracellular neurotransmitters. BACHD mice had no change in GLT1 expression, decreased striatal GAT1 expression and increased levels of GAT3. There was no change in GAT1 after reducing astrocytic SNARE-dependent exocytosis, and increased GAT3 expression in BACHD mice was normalized in BACHD\/dnSNARE mice. Thus, modulation of astrocytic SNARE-dependent exocytosis in BACHD mice is protective against striatal atrophy and modulates GABA transporter expression.<\/jats:p>","DOI":"10.1242\/dmm.052002","type":"journal-article","created":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T10:46:54Z","timestamp":1731322014000},"source":"Crossref","is-referenced-by-count":4,"title":["Modulation of SNARE-dependent exocytosis in astrocytes improves neuropathology in Huntington's disease"],"prefix":"10.1242","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8727-2903","authenticated-orcid":false,"given":"Annesha C.","family":"King","sequence":"first","affiliation":[{"name":"Graduate Biomedical Sciences Neuroscience Theme, University of Alabama at Birmingham 1 , Birmingham, AL 35294 ,","place":["USA"]},{"name":"Center for Neurodegeneration and Experimental Therapeutics, University of Alabama 2 Department of Neurology , at Birmingham, Birmingham, AL 35294 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Payne","sequence":"additional","affiliation":[{"name":"Center for Neurodegeneration and Experimental Therapeutics, University of Alabama 2 Department of Neurology , at Birmingham, Birmingham, AL 35294 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Stephens","sequence":"additional","affiliation":[{"name":"Center for Neurodegeneration and Experimental Therapeutics, University of Alabama 2 Department of Neurology , at Birmingham, Birmingham, AL 35294 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jahmel A.","family":"Fowler","sequence":"additional","affiliation":[{"name":"Center for Neurodegeneration and Experimental Therapeutics, University of Alabama 2 Department of Neurology , at Birmingham, Birmingham, AL 35294 ,","place":["USA"]},{"name":"Graduate Biomedical Sciences Biochemistry and Structural Biology Theme, University of Alabama at Birmingham 3 , Birmingham, AL 35294 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tara E.","family":"Wood","sequence":"additional","affiliation":[{"name":"Center for Neurodegeneration and Experimental Therapeutics, University of Alabama 2 Department of Neurology , at Birmingham, Birmingham, AL 35294 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Efrain","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Center for Neurodegeneration and Experimental Therapeutics, University of Alabama 2 Department of Neurology , at Birmingham, Birmingham, AL 35294 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0808-108X","authenticated-orcid":false,"given":"Michelle","family":"Gray","sequence":"additional","affiliation":[{"name":"Center for Neurodegeneration and Experimental Therapeutics, University of Alabama 2 Department of Neurology , at Birmingham, Birmingham, AL 35294 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2024,11,11]]},"reference":[{"key":"2024111110462687600_DMM052002C1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/1098-1136(200010)32:1&lt;1::AID-GLIA10&gt;3.0.CO;2-W","article-title":"Astrocyte glutamate transport: review of properties, regulation, and physiological functions","volume":"32","author":"Anderson","year":"2000","journal-title":"Glia"},{"key":"2024111110462687600_DMM052002C2","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1111\/j.1755-5949.2010.00134.x","article-title":"Dopamine and glutamate in Huntington's disease: a balancing act","volume":"16","author":"Andr\u00e9","year":"2010","journal-title":"CNS Neurosci. 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