{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:34:33Z","timestamp":1787319273141,"version":"build-2736575974"},"reference-count":101,"publisher":"The Company of Biologists","issue":"1","license":[{"start":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T00:00:00Z","timestamp":1738022400000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100014748","name":"Clarendon Fund","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100014748","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Ludwig Institute for Cancer Research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Gestational trophoblastic disease (GTD) describes a group of rare benign and cancerous lesions originating from the trophoblast cells of the placenta. These neoplasms are unconventional entities, being one of the few instances in which cancer develops from the cells of another organism, the foetus. Although this condition was first described over 100\u2005years ago, the specific genetic and non-genetic drivers of this disease remain unknown to this day. However, recent findings have provided valuable insights into the potential mechanisms underlying this rare condition. Unlike previous reviews focused primarily on the clinical and diagnostic aspects of disease development, this Review consolidates the latest research concerning the role of genetics, epigenetics and microRNAs in the initiation and progression of GTD. By examining GTD from a molecular perspective, this Review provides a unique framework for understanding the pathogenesis and progression of this rare disease.<\/jats:p>","DOI":"10.1242\/dmm.052010","type":"journal-article","created":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T04:35:12Z","timestamp":1738038912000},"source":"Crossref","is-referenced-by-count":6,"title":["Gestational trophoblastic disease: understanding the molecular mechanisms of placental tumours"],"prefix":"10.1242","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7318-9065","authenticated-orcid":false,"given":"Alina","family":"Nicheperovich","sequence":"first","affiliation":[{"name":"Ludwig Institute for Cancer Research 1 , Nuffield Department of Medicine , , Oxford OX3 7DQ ,","place":["UK"]},{"name":"University of Oxford 1 , Nuffield Department of Medicine , , Oxford OX3 7DQ ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8892-5133","authenticated-orcid":false,"given":"Benjamin","family":"Schuster-B\u00f6ckler","sequence":"additional","affiliation":[{"name":"Ludwig Institute for Cancer Research 1 , Nuffield Department of Medicine , , Oxford OX3 7DQ ,","place":["UK"]},{"name":"University of Oxford 1 , Nuffield Department of Medicine , , Oxford OX3 7DQ ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8523-4935","authenticated-orcid":false,"given":"M\u00e1ire","family":"N\u00ed Leathlobhair","sequence":"additional","affiliation":[{"name":"Trinity College 2 Department of Microbiology , , Dublin D02 VF25 ,","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2025,1,28]]},"reference":[{"key":"2025012809350722300_DMM052010C1","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/s0165-4608(99)00103-x","article-title":"Comparative genomic hybridization studies in hydatidiform moles and choriocarcinoma: amplification of 7q21-q31 and loss of 8p12-p21 in choriocarcinoma","volume":"116","author":"Ahmed","year":"2000","journal-title":"Cancer Genet. 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