{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T03:16:28Z","timestamp":1783134988148,"version":"3.54.6"},"reference-count":42,"publisher":"The Company of Biologists","issue":"11","license":[{"start":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T00:00:00Z","timestamp":1731888000000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004763","name":"Natural Science Foundation of Inner Mongolia Autonomous Region","doi-asserted-by":"crossref","award":["2024MS03003"],"award-info":[{"award-number":["2024MS03003"]}],"id":[{"id":"10.13039\/501100004763","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100013093","name":"Science and Technology Planning Project of Shenzen Municipality","doi-asserted-by":"crossref","award":["JCYJ20230807110800002"],"award-info":[{"award-number":["JCYJ20230807110800002"]}],"id":[{"id":"10.13039\/501100013093","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["32170831"],"award-info":[{"award-number":["32170831"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Natural Science Foundation of Shanghai Municipality","award":["22ZR1435300"],"award-info":[{"award-number":["22ZR1435300"]}]},{"name":"National Key Research and Development Program of China","award":["2022YFA0912600"],"award-info":[{"award-number":["2022YFA0912600"]}]},{"DOI":"10.13039\/501100004921","name":"Shanghai Jiao Tong University","doi-asserted-by":"crossref","award":["YG2023QNB31"],"award-info":[{"award-number":["YG2023QNB31"]}],"id":[{"id":"10.13039\/501100004921","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Airway mucous cell metaplasia is a significant feature of many chronic airway diseases, such as chronic obstructive pulmonary disease, cystic fibrosis and asthma. However, the mechanisms underlying this process remain poorly understood. Here, we employed in vivo mouse genetic models to demonstrate that Hippo and p53 (encoded by Trp53) cooperate to modulate the differentiation of club cells into goblet cells. We revealed that ablation of Mst1 (Stk4) and Mst2 (Stk3), encoding the core components of Hippo signaling, significantly reduces mucous metaplasia in the lung airways in a lipopolysaccharide (LPS)-induced lung inflammation murine model while promoting club cell proliferation in a Yap (Yap1)-dependent manner. Additionally, we showed that deleting Mst1\/2 is sufficient to suppress p53 deficiency-mediated goblet cell metaplasia. Finally, single-cell RNA-sequencing analysis revealed downregulation of YAP and p53 signaling in goblet cells in human airways. These findings underscore the important role of Hippo and p53 signaling in regulating airway mucous metaplasia.<\/jats:p>","DOI":"10.1242\/dmm.052074","type":"journal-article","created":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T06:58:13Z","timestamp":1729493893000},"source":"Crossref","is-referenced-by-count":1,"title":["Hippo cooperates with p53 to regulate lung airway mucous cell metaplasia"],"prefix":"10.1242","volume":"17","author":[{"given":"Jiangying","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, Inner Mongolia Research Institute, Shenzhen Research Institute, Sheng Yushou Center of Cell Biology and Immunology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University 1 , Shanghai 200240 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of Genetic Engineering, School of Life Sciences, Greater Bay Area Institute of Precision Medicine (Guangzhou), Zhongshan Hospital, Fudan University Shanghai 5 , Shanghai 200438 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haihan","family":"Song","sequence":"additional","affiliation":[{"name":"Central Lab, Shanghai Key Laboratory of Pathogenic Fungi Medical Testing, Shanghai Pudong New Area People's Hospital 6 , Shanghai 201299 ,","place":["China"]},{"name":"DICAT National Biomedical Computation Centre 7 Department of Immunology , , Vancouver, BC V6B 5A6 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9949-0604","authenticated-orcid":false,"given":"Yongchun","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, Inner Mongolia Research 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