{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T23:59:54Z","timestamp":1789430394923,"version":"build-2803163510"},"reference-count":56,"publisher":"The Company of Biologists","issue":"12","license":[{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"D. E. 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Pathological manifestations were assessed through clinical scoring of hind paw swelling, histological analysis, and evaluation of RA-specific markers in plasma and joints using Luminex, RT-PCR and RNA sequencing. NSG-RA mice exhibited increased levels of RA-specific markers, an influx of inflammatory cells into the synovium, bone erosion and elevated levels of human autoantibodies. Enriched RNA-sequencing pathway analysis revealed activation of the RA disease pathway, along with the TNF and IL-17 signalling pathways. Treatment with prednisolone or infliximab ameliorated disease symptoms and decreased levels of inflammatory markers. These findings indicate that the NSG-RA model offers a translational tool for studying RA pathogenesis and testing novel therapeutic approaches.<\/jats:p>","DOI":"10.1242\/dmm.052294","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T08:10:05Z","timestamp":1758528605000},"source":"Crossref","is-referenced-by-count":3,"title":["Validation of a model of rheumatoid arthritis using mice reconstituted with patient peripheral blood mononuclear cells"],"prefix":"10.1242","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6516-6912","authenticated-orcid":false,"given":"Paula","family":"Schuster-Winkelmann","sequence":"first","affiliation":[{"name":"Hospital of the LMU, LMU Munich 1 Department of General, Visceral and Transplantation Surgery , , 80336 Munich ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika","family":"We\u00df","sequence":"additional","affiliation":[{"name":"Hospital of the LMU, LMU Munich 1 Department of General, Visceral and Transplantation Surgery , , 80336 Munich ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marietta","family":"Schindler","sequence":"additional","affiliation":[{"name":"Hospital of the LMU, LMU Munich 1 Department of General, Visceral and Transplantation Surgery , , 80336 Munich ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten \u00d8.","family":"Jensen","sequence":"additional","affiliation":[{"name":"D. 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Shaw Research 2 , New York, NY 10036 ,","place":["USA"]},{"name":"Columbia University 3 Department of Biochemistry and Molecular Biophysics , , New York, NY 10032 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Alberton","sequence":"additional","affiliation":[{"name":"LMU University Hospital, LMU Munich 4 Department for Orthopaedics and Trauma Surgery Musculoskeletal University Center Munich (MUM) , , 81377 Munich ,","place":["Germany"]},{"name":"LMU University Hospital, LMU Munich 5 Division of Hand, Plastic and Aesthetic Surgery , , 81377 Munich ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrik","family":"Schulze-Koops","sequence":"additional","affiliation":[{"name":"Hospital of the LMU, LMU Munich 6 Department of Med. 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