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Recently, ZBTB33 mutations have been implicated in myelodysplastic syndromes and suggested as a driver of CH. However, the role of ZBTB33 in hematopoiesis and its involvement in CH remains unclear. We generated a Zbtb33-knockout mouse strain to elucidate the function of Zbtb33 in hematopoiesis and tumor growth. Our findings indicated that hematopoiesis in Zbtb33-knockout mice was normal, and competitive bone marrow transplantation assays demonstrated that loss of Zbtb33 in HSCs did not confer expansional advantage. Introducing Zbtb33 mutation into Tet2- or P53-mutation background yielded no synergistic effects. Nevertheless, tumor-bearing experiments revealed that hematopoietic loss of Zbtb33 accelerated solid tumor growth. In summary, Zbtb33 knockout was insufficient to induce CH in mice but may play a role in tumor growth through the hematopoietic compartment.<\/jats:p>","DOI":"10.1242\/dmm.052484","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:37:42Z","timestamp":1791272262000},"source":"Crossref","is-referenced-by-count":0,"title":["Loss of transcription factor\n                    <i>Zbtb33<\/i>\n                    fails to induce clonal hematopoiesis but plays a role in tumor growth"],"prefix":"10.1242","volume":"19","author":[{"given":"Yuhang","family":"Li","sequence":"first","affiliation":[{"name":"Tianjin Medical University 1 State Key Laboratory of Experimental Hematology , , Tianjin 300037 ,","place":["China"]},{"name":"School of Basic Medical Science, Tianjin Medical University 2 Tianjin Key Laboratory of Inflammatory Biology, Department of Pharmacology , , Tianjin 300037 ,","place":["China"]},{"name":"School of Basic Medical Science, Tianjin Medical University 3 The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics , , Tianjin 300037 ,","place":["China"]},{"name":"Affiliated Hospital of Nankai University 4 Department of Medical Oncology, Tianjin First Central Hospital , , Tianjin 300192 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiping","family":"Luo","sequence":"additional","affiliation":[{"name":"Tianjin Medical University 1 State Key Laboratory of Experimental Hematology , , Tianjin 300037 ,","place":["China"]},{"name":"School of Basic Medical Science, Tianjin Medical University 2 Tianjin Key Laboratory of Inflammatory Biology, Department of Pharmacology , , Tianjin 300037 ,","place":["China"]},{"name":"School of Basic Medical Science, Tianjin Medical University 3 The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics , , Tianjin 300037 ,","place":["China"]},{"name":"Affiliated Hospital of Nankai 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