{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T08:08:02Z","timestamp":1779437282201,"version":"3.53.1"},"reference-count":66,"publisher":"The Company of Biologists","issue":"5","license":[{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100006447","name":"Universit\u00e4t Z\u00fcrich","doi-asserted-by":"crossref","award":["4141100"],"award-info":[{"award-number":["4141100"]}],"id":[{"id":"10.13039\/501100006447","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Center of Competence in Research-Kidney Control of Homeostasis"},{"name":"European Reference Network for Rare Kidney Diseases"},{"DOI":"10.13039\/100019765","name":"Third Framework Programme","doi-asserted-by":"crossref","award":["2017-2021"],"award-info":[{"award-number":["2017-2021"]}],"id":[{"id":"10.13039\/100019765","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100005674","name":"Cystinosis Research Foundation","doi-asserted-by":"crossref","award":["CRFS-2017-007"],"award-info":[{"award-number":["CRFS-2017-007"]}],"id":[{"id":"10.13039\/100005674","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100005674","name":"Cystinosis Research Foundation","doi-asserted-by":"crossref","award":["CRFS-2023-003"],"award-info":[{"award-number":["CRFS-2023-003"]}],"id":[{"id":"10.13039\/100005674","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100005674","name":"Cystinosis Research Foundation","doi-asserted-by":"crossref","award":["CRFS-2020-005"],"award-info":[{"award-number":["CRFS-2020-005"]}],"id":[{"id":"10.13039\/100005674","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"crossref","award":["310030_215715"],"award-info":[{"award-number":["310030_215715"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82100752"],"award-info":[{"award-number":["82100752"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>An efficient endolysosomal pathway is crucial to mediate the reabsorption and processing of ultrafiltered solutes including low-molecular-weight (LMW) proteins by epithelial cells lining the proximal tubule (PT) of the kidney. The zebrafish pronephros is used as a model system for congenital or acquired disorders that impair endolysosomal processing in PT cells, causing inappropriate loss of solutes and LMW proteins in urine. Here, we describe a new reporter \u00bdvdbp-NanoLuc zebrafish line, in which vitamin D-binding protein is coupled to NanoLuc luciferase for detection of PT dysfunction and LMW proteinuria. We demonstrate the reliability and value of the \u00bdvdbp-NanoLuc biosensor in fish models of monogenic endolysosomal diseases, gentamicin and cisplatin-induced nephrotoxicity, and metal contamination. This novel reporter system yields mechanistic insights into cadmium- and copper-induced PT dysfunction and provides a platform for drug screening.<\/jats:p>","DOI":"10.1242\/dmm.052673","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T07:29:09Z","timestamp":1775546949000},"source":"Crossref","is-referenced-by-count":0,"title":["A zebrafish luminescent biosensor for kidney tubulopathy, metal toxicity and drug screening"],"prefix":"10.1242","volume":"19","author":[{"given":"Han","family":"Lai","sequence":"first","affiliation":[{"name":"University of Zurich 1 Department of Physiology , , 8057 Zurich ,","place":["Switzerland"]},{"name":"First Affiliated Hospital of Chongqing Medical University 2 Department of Nephrology , , Chongqing 400016 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Goldade","sequence":"additional","affiliation":[{"name":"University of Zurich 1 Department of Physiology , , 8057 Zurich ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svenja Aline","family":"Keller","sequence":"additional","affiliation":[{"name":"University of Zurich 1 Department of Physiology , , 8057 Zurich ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Worms","sequence":"additional","affiliation":[{"name":"School of Earth and Environmental Sciences 3 Department F.-A. Forel for Environmental and Aquatic Sciences , , Faculty of Science , , CH-1211 Geneva 4 ,","place":["Switzerland"]},{"name":"University of Geneva 3 Department F.-A. Forel for Environmental and Aquatic Sciences , , Faculty of Science , , CH-1211 Geneva 4 ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Luciani","sequence":"additional","affiliation":[{"name":"University of Zurich 1 Department of Physiology , , 8057 Zurich ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan C. F.","family":"Neuhauss","sequence":"additional","affiliation":[{"name":"University of Zurich 4 Department of Molecular Life Sciences , , 8057 Zurich ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera I.","family":"Slaveykova","sequence":"additional","affiliation":[{"name":"School of Earth and Environmental Sciences 3 Department F.-A. 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