{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T06:56:39Z","timestamp":1790578599410,"version":"4.1.0"},"reference-count":87,"publisher":"The Company of Biologists","issue":"9","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Leiden University","id":[{"id":"https:\/\/ror.org\/027bh9e22","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Most cancer therapeutics that show preclinical promise fail in clinical trials, underscoring the need for complementary disease models. Over the past two decades, zebrafish models have matured from a tool for studying vertebrate development into a versatile platform spanning the translational cancer pipeline. Transgenic and transplantation zebrafish models have dissected fundamental mechanisms of tumor initiation and metastasis. Beyond mechanistic insight, phenotypic chemical and genetic screens provide a rapid, whole-organism filter to prioritize and repurpose therapeutic candidates, several of which have reached the clinic. Most recently, zebrafish patient-derived xenografts have begun to predict individual patient treatment responses within clinically actionable timeframes. Tracing this evolution, we argue that zebrafish models are not a replacement for other systems but earn their translational value when applied to the questions they answer best and when embedded in co-clinical workflows alongside oncology teams.<\/jats:p>","DOI":"10.1242\/dmm.053145","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T06:25:54Z","timestamp":1790576754000},"source":"Crossref","is-referenced-by-count":0,"title":["Zebrafish against cancer: towards clinical relevance"],"prefix":"10.1242","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5976-4759","authenticated-orcid":false,"given":"Gabriel","family":"Forn-Cuni","sequence":"first","affiliation":[{"name":"Department of Animal Sciences, Institute of Biology Leiden, Leiden University 1 , Einsteinweg 55, 2333 CC Leiden ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0517-9455","authenticated-orcid":false,"given":"Bruno","family":"Lopes-Bastos","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences, Institute of Biology Leiden, Leiden University 1 , Einsteinweg 55, 2333 CC Leiden ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Langenau","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital 2 Molecular Pathology Unit , , Charlestown, MA ,","place":["USA"]},{"name":"Krantz Family Center for Cancer Research, Massachusetts General Hospital 3 , Charlestown, MA 02129 ,","place":["USA"]},{"name":"Harvard Stem Cell Institute, Harvard Medical School 4 , Cambridge, MA 02138 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Elizabeth","family":"Patton","sequence":"additional","affiliation":[{"name":"Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital Campus 5 MRC Human Genetics Unit , , Edinburgh EH4 2XU ,","place":["UK"]},{"name":"Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh 6 , Edinburgh EH4 2XU ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3772-047X","authenticated-orcid":false,"given":"B. 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