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Recent studies have identified many of the relevant actin-regulatory proteins, and significant progress has been made in our understanding of how these proteins choreograph molecular movements associated with T-cell activation. Proteins such as WASp, WAVE2, HS1 and cofilin direct the formation of a cortical actin scaffold at the immune synapse, while actin-binding proteins such as ezrin and moesin direct binding of signaling molecules to actin filaments within the distal pole complex.<\/jats:p>","DOI":"10.1242\/jcs.000786","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T18:41:34Z","timestamp":1172083294000},"page":"723-730","source":"Crossref","is-referenced-by-count":73,"title":["T-cell-receptor-dependent actin regulatory mechanisms"],"prefix":"10.1242","volume":"120","author":[{"given":"Yanping","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia and University of Pennsylvania School of Medicine, 816D Abramson Research Center, 3615 Civic Center Blvd., Philadelphia, PA 19104, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janis K.","family":"Burkhardt","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia and University of Pennsylvania School of Medicine, 816D Abramson Research Center, 3615 Civic Center Blvd., Philadelphia, PA 19104, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042523375364700_REF1","doi-asserted-by":"crossref","unstructured":"Allenspach, E. 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