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By using LPSs from bacteria that do not belong to the Enterobacteriaceae, we show that in bone marrow cells (BMCs) the LPS of Rhizobium species Sin-1 and of three strains of Legionella pneumophila require TLR2 rather than TLR4 to elicit the expression of CD14. In addition, exposure of BMCs from TLR4-deficient (C3H\/HeJ) mice to the lipid A fragment of the Bordetella pertussis LPS inhibits their activation by the Legionella lipid A. The data show selective action of different LPSs via different TLRs, and suggest that TLR2 can interact with many lipid A structures, leading to either agonistic or specific antagonistic effects.<\/jats:p>","DOI":"10.1242\/jcs.00212","type":"journal-article","created":{"date-parts":[[2002,12,13]],"date-time":"2002-12-13T18:22:55Z","timestamp":1039803775000},"page":"293-302","source":"Crossref","is-referenced-by-count":123,"title":["Lipopolysaccharides from<i>Legionella<\/i>and<i>Rhizobium<\/i>stimulate mouse bone marrow granulocytes via Toll-like receptor 2"],"prefix":"10.1242","volume":"116","author":[{"given":"Robert","family":"Girard","sequence":"first","affiliation":[{"name":"Lymphocyte development, URA-1961 of the National Center for Scientific Research, Pasteur Institute, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Pedron","sequence":"additional","affiliation":[{"name":"Pathoge\u0301nie Microbienne Mole\u0301culaire, Unite\u0301 INSERM U389, Institut Pasteur, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Uematsu","sequence":"additional","affiliation":[{"name":"Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviane","family":"Balloy","sequence":"additional","affiliation":[{"name":"De\u0301fense Inne\u0301e et Inflammation, Unite\u0301 associe\u0301e IP\/Inserm Z485, Institut Pasteur, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Chignard","sequence":"additional","affiliation":[{"name":"De\u0301fense Inne\u0301e et Inflammation, Unite\u0301 associe\u0301e IP\/Inserm Z485, Institut Pasteur, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shizuo","family":"Akira","sequence":"additional","affiliation":[{"name":"Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Chaby","sequence":"additional","affiliation":[{"name":"Endotoxin Group, UMR-8619 of the National Center for Scientific Research, University of Paris-Sud, Orsay, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042517463211100_REF1","doi-asserted-by":"crossref","unstructured":"Aliprantis, A. 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