{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T02:29:56Z","timestamp":1789698596633,"version":"4.0.1"},"reference-count":68,"publisher":"The Company of Biologists","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,3,1]]},"abstract":"<jats:p>The events responsible for repair of DNA interstrand cross-links in mammalian cells, the proteins involved and their interactions with each other are poorly understood. The present study demonstrates that the structural protein nonerythroid \u03b1 spectrin (\u03b1SpII\u03a3*), present in normal human cell nuclei, plays an important role in repair of DNA interstrand cross-links. These results show that \u03b1SpII\u03a3* relocalizes to nuclear foci after damage of normal human cells with the DNA interstrand cross-linking agent 8-methoxypsoralen plus ultraviolet A (UVA) light and that FANCA and the known DNA repair protein XPF localize to the same nuclear foci. That \u03b1SpII\u03a3* is essential for this re-localization is demonstrated by the finding that in cells from patients with Fanconi anemia complementation group A (FA-A), which have decreased ability to repair DNA interstrand cross-links and decreased levels of \u03b1SpII\u03a3*, there is a significant reduction in formation of damage-induced XPF as well as\u03b1SpII\u03a3* nuclear foci, even though levels of XPF are normal in these cells. In corrected FA-A cells, in which levels of \u03b1SpII\u03a3*are restored to normal, numbers of damage-induced nuclear foci are also returned to normal. Co-immunoprecipitation studies show that\u03b1SpII\u03a3*, FANCA and XPF co-immunoprecipitate with each other from normal human nuclear proteins. These results demonstrate that\u03b1SpII\u03a3*, FANCA and XPF interact with each other in the nucleus and indicate that there is a close functional relationship between these proteins. These studies suggest that an important role for \u03b1SpII\u03a3* in the nucleus is to act as a scaffold, aiding in recruitment and alignment of repair proteins at sites of damage.<\/jats:p>","DOI":"10.1242\/jcs.00294","type":"journal-article","created":{"date-parts":[[2003,2,6]],"date-time":"2003-02-06T02:02:33Z","timestamp":1044496953000},"page":"823-835","source":"Crossref","is-referenced-by-count":86,"title":["Nonerythroid \u03b1II spectrin is required for recruitment of FANCA and XPF to nuclear foci induced by DNA interstrand cross-links"],"prefix":"10.1242","volume":"116","author":[{"given":"Deepa","family":"Sridharan","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, UMDNJ \u2014 New Jersey Medical School and the Graduate School of Biomedical Sciences, Newark, NJ 07103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, UMDNJ \u2014 New Jersey Medical School and the Graduate School of Biomedical Sciences, Newark, NJ 07103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Clark","family":"Lambert","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, UMDNJ \u2014 New Jersey Medical School and the Graduate School of Biomedical Sciences, Newark, NJ 07103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura W.","family":"McMahon","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, UMDNJ \u2014 New Jersey Medical School and the Graduate School of Biomedical Sciences, Newark, NJ 07103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muriel W.","family":"Lambert","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, UMDNJ \u2014 New Jersey Medical School and the Graduate School of Biomedical Sciences, Newark, NJ 07103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042517530916800_REF1","doi-asserted-by":"crossref","unstructured":"Ahmad, S. 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