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Oscillating cells were typically located in clusters of closely apposed cells, but Ca2+spiking was insensitive to the gap junction inhibitor 18\u03b1-glycyrrhetinic acid. We hypothesized that Ca2+ signals might be amplified, in part, through a positive feedback loop in which Ca2+ extrusion via the plasma membrane Ca2+-ATPase (PMCA) activates CaRs on the same cell or adjacent cells through local increases in[Ca2+]out. In support of this idea, addition of exogenous Ca2+ buffers (keeping free[Ca2+]out constant) attenuated or eliminated Ca2+ signals (manifested as oscillations), as did PMCA inhibitors(HgCl2, orthovanadate and Caloxin 2A1). Measurement of extracellular [Ca2+] using the near membrane probe fura-C18 revealed that external [Ca2+] rose following receptor activation, sometimes displaying an oscillatory pattern. Our data suggest that PMCA-mediated cycling of Ca2+ across the plasma membrane leads to localized increases in [Ca2+]out that increase the excitability of CaR.<\/jats:p>","DOI":"10.1242\/jcs.00368","type":"journal-article","created":{"date-parts":[[2003,3,14]],"date-time":"2003-03-14T17:08:58Z","timestamp":1047661738000},"page":"1527-1538","source":"Crossref","is-referenced-by-count":38,"title":["Evidence that Ca2+ cycling by the plasma membrane Ca2+-ATPase increases the `excitability' of the extracellular Ca2+-sensing receptor"],"prefix":"10.1242","volume":"116","author":[{"given":"Annunziata","family":"De Luisi","sequence":"first","affiliation":[{"name":"Dipartimento di Fisiologia Generale ed Ambientale, Universita\u0301 di Bari,Via Amendola 165\/A, I-70126 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aldebaran M.","family":"Hofer","sequence":"additional","affiliation":[{"name":"West Roxbury VAMC and the Department of Surgery, Harvard Medical School, West Roxbury, MA 02132, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","reference":[{"key":"2021042518314042200_REF1","doi-asserted-by":"crossref","unstructured":"Bai, M., Trivedi, S., Lane, C. 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