{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T05:27:48Z","timestamp":1785475668852,"version":"3.56.0"},"reference-count":53,"publisher":"The Company of Biologists","issue":"17","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,9,1]]},"abstract":"<jats:p>Growth factor-induced cell migration and proliferation are essential for epithelial wound repair. Cell migration during wound repair also depends upon expression of laminin-5, a ligand for \u03b16\u03b24 integrin. We investigated the role of \u03b16\u03b24 integrin in laminin-5-dependent keratinocyte migration by re-expressing normal or attachment-defective \u03b24 integrin in \u03b24 integrin null keratinocytes. We found that expression of\u03b24 integrin in either a ligand bound or ligand unbound state was necessary and sufficient for EGF-induced cell migration. In a ligand bound state, \u03b24 integrin supported EGF-induced cell migration though sustained activation of Rac1. In the absence of \u03b16\u03b24 integrin ligation, Rac1 activation became tempered and EGF chemotaxis proceeded through an alternate mechanism that depended upon \u03b13\u03b21 integrin and was characterized by cell scattering. \u03b13\u03b21 integrin also relocalated from cell-cell contacts to sites of basal clustering where it displayed increased conformational activation. The aberrant distribution and activation of\u03b13\u03b21 integrin in attachment-defective \u03b24 cells could be reversed by the activation of Rac1. Conversely, in WT \u03b24 cells the normal cell-cell localization of \u03b13\u03b21 integrin became aberrant after the inhibition of Rac1. These studies indicate that the extracellular domain of\u03b24 integrin, through its ability to bind ligand, functions to integrate the divergent effects of growth factors on the cytoskeleton and adhesion receptors so that coordinated keratinocyte migration can be achieved.<\/jats:p>","DOI":"10.1242\/jcs.00663","type":"journal-article","created":{"date-parts":[[2003,7,21]],"date-time":"2003-07-21T20:23:27Z","timestamp":1058819007000},"page":"3543-3556","source":"Crossref","is-referenced-by-count":118,"title":["\u03b16\u03b24 integrin regulates keratinocyte chemotaxis through differential GTPase activation and antagonism of \u03b13\u03b21 integrin"],"prefix":"10.1242","volume":"116","author":[{"given":"Alan J.","family":"Russell","sequence":"first","affiliation":[{"name":"Program in Epithelial Biology, Stanford University School of Medicine,Stanford, CA 94305, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar F.","family":"Fincher","sequence":"additional","affiliation":[{"name":"Program in Epithelial Biology, Stanford University School of Medicine,Stanford, CA 94305, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Millman","sequence":"additional","affiliation":[{"name":"Program in Epithelial Biology, Stanford University School of Medicine,Stanford, CA 94305, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robyn","family":"Smith","sequence":"additional","affiliation":[{"name":"Program in Epithelial Biology, Stanford University School of Medicine,Stanford, CA 94305, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Vela","sequence":"additional","affiliation":[{"name":"Program in Epithelial Biology, Stanford University School of Medicine,Stanford, CA 94305, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Waterman","sequence":"additional","affiliation":[{"name":"Program in Epithelial Biology, Stanford University School of Medicine,Stanford, CA 94305, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara N.","family":"Dey","sequence":"additional","affiliation":[{"name":"Program in Epithelial Biology, Stanford University School of Medicine,Stanford, CA 94305, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shireen","family":"Guide","sequence":"additional","affiliation":[{"name":"Program in Epithelial Biology, Stanford University School of Medicine,Stanford, CA 94305, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie M.","family":"Weaver","sequence":"additional","affiliation":[{"name":"Pathology & Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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