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Since NF-\u03baB plays a crucial role in the adaptive immune response (e.g. in lymphocyte proliferation and cytokine production), it is important to understand the molecular mechanisms by which NF-\u03baB is regulated. Nevertheless, the connection between PKC activation and NF-\u03baB has remained a mystery that has now been at least partly solved. Recent findings implicate a new scaffolding protein, Bimp3\/CARMA1\/CARD11, as a key factor in bridging PKC activation with the downstream activation of Bcl10 and MALT1, which ultimately stimulates NF-\u03baB. Since some of these signaling components are lymphocyte specific, therapeutic agents that block this pathway could blunt the inappropriate proliferation of lymphocytes associated with certain inflammatory and neoplastic disorders. Alternatively, agents that specifically augment this pathway, thereby enhancing immune function in immunodeficiency, may be developed.<\/jats:p>","DOI":"10.1242\/jcs.00904","type":"journal-article","created":{"date-parts":[[2003,12,2]],"date-time":"2003-12-02T05:23:14Z","timestamp":1070342594000},"page":"31-39","source":"Crossref","is-referenced-by-count":81,"title":["NF-\u03baB signaling in lymphocytes: a new cast of characters"],"prefix":"10.1242","volume":"117","author":[{"given":"Peter C.","family":"Lucas","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Michigan Medical School, 4131 CCGC, 1500 East Medical Center Dr., Ann Arbor, MI 48109, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda M.","family":"McAllister-Lucas","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Michigan Medical School, 4131 CCGC, 1500 East Medical Center Dr., Ann Arbor, MI 48109, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel","family":"Nun\u0303ez","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Michigan Medical School, 4131 CCGC, 1500 East Medical Center Dr., Ann Arbor, MI 48109, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","reference":[{"key":"2021042517545952300_REF1","doi-asserted-by":"crossref","unstructured":"Acuto, O., Mise-Omata, S., Mangino, G. and Michel, F. 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