{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T23:59:25Z","timestamp":1791071965543,"version":"4.1.0"},"reference-count":36,"publisher":"The Company of Biologists","issue":"15","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,7,1]]},"abstract":"<jats:p>Resistin, a recently cloned adipose-secreted factor, is primarily involved in the modulation of insulin sensitivity and adipocyte differentiation. However, additional metabolic or endocrine functions of this molecule remain largely unexplored. In this study, a series of experiments were undertaken to explore the potential expression, regulation and functional role of this novel adipocytokine in rat testis. Resistin gene expression was demonstrated in rat testis throughout postnatal development, with maximum mRNA levels in adult specimens. At this age, resistin peptide was immunodetected in interstitial Leydig cells and Sertoli cells within seminiferous tubules. Testicular expression of resistin was under hormonal regulation of pituitary gonadotropins and showed stage-specificity, with peak expression values at stages II-VI of the seminiferous epithelial cycle. In addition, testicular resistin mRNA was down-regulated by the selective agonist of PPAR\u03b3, rosiglitazone, in vivo and in vitro. Similarly, fasting and central administration of the adipocyte-derived factor, leptin, evoked a significant reduction in testicular resistin mRNA levels, whereas they remained unaltered in a model of diet-induced obesity. From a functional standpoint, resistin, in a dose-dependent manner, significantly increased both basal and choriogonadotropin-stimulated testosterone secretion in vitro. Overall, our present results provide the first evidence for the expression, regulation and functional role of resistin in rat testis. These data underscore a reproductive facet of this recently cloned molecule, which may operate as a novel endocrine integrator linking energy homeostasis and reproduction.<\/jats:p>","DOI":"10.1242\/jcs.01196","type":"journal-article","created":{"date-parts":[[2004,6,28]],"date-time":"2004-06-28T17:48:06Z","timestamp":1088444886000},"page":"3247-3257","source":"Crossref","is-referenced-by-count":91,"title":["Novel expression of resistin in rat testis: functional role and regulation by nutritional status and hormonal factors"],"prefix":"10.1242","volume":"117","author":[{"given":"Ruben","family":"Nogueiras","sequence":"first","affiliation":[{"name":"Department of Physiology, University of Santiago de Compostela, c\/San Francisco s\/n, 15705 Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Luz","family":"Barreiro","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Physiology and Immunology, University of Co\u0301rdoba, Avda. Menendez Pidal s\/n, 14004 Co\u0301rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge E.","family":"Caminos","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Santiago de Compostela, c\/San Francisco s\/n, 15705 Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Gayta\u0301n","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Physiology and Immunology, University of Co\u0301rdoba, Avda. Menendez Pidal s\/n, 14004 Co\u0301rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janne S.","family":"Suominen","sequence":"additional","affiliation":[{"name":"Department of Physiology and Department of Pediatrics, University of Turku, Kiinamyllynkatu 10, 20520 Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor M.","family":"Navarro","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Physiology and Immunology, University of Co\u0301rdoba, Avda. Menendez Pidal s\/n, 14004 Co\u0301rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe F.","family":"Casanueva","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Santiago de Compostela, c\/San Francisco s\/n, 15705 Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Aguilar","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Physiology and Immunology, University of Co\u0301rdoba, Avda. Menendez Pidal s\/n, 14004 Co\u0301rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorma","family":"Toppari","sequence":"additional","affiliation":[{"name":"Department of Physiology and Department of Pediatrics, University of Turku, Kiinamyllynkatu 10, 20520 Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Die\u0301guez","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Santiago de Compostela, c\/San Francisco s\/n, 15705 Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Tena-Sempere","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Physiology and Immunology, University of Co\u0301rdoba, Avda. 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Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisome proliferator-activated receptor gamma agonists. J. Biol. 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