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Z4 mutants have a dose-sensitive effect on wm4 position effect variegation with a haplo-suppressor and triplo-enhancer phenotype, suggesting Z4 to be involved in chromatin compaction. This assumption is further supported by the phenotype of Z4 mutant chromosomes, which show a loss of the band\/interband pattern and are subject to an overall decompaction of chromosomal material. By co-immunoprecipitations we identified a novel chromo domain protein, which we named Chriz (Chromo domain protein interacting with Z4) as an interaction partner of Z4. Chriz localizes to interbands in a pattern that is identical to the Z4 pattern. These findings together with the result that Z4 binds directly to DNA in vitro strongly suggest that Z4 in conjunction with Chriz is intimately involved in the higher-order structuring of chromosomes.<\/jats:p>","DOI":"10.1242\/jcs.01292","type":"journal-article","created":{"date-parts":[[2004,8,4]],"date-time":"2004-08-04T01:08:29Z","timestamp":1091581709000},"page":"4253-4264","source":"Crossref","is-referenced-by-count":56,"title":["Identification of the Drosophila interband-specific protein Z4 as a DNA-binding zinc-finger protein determining chromosomal structure"],"prefix":"10.1242","volume":"117","author":[{"given":"Harald","family":"Eggert","sequence":"first","affiliation":[{"name":"Humboldt University Berlin, Institute of Biology, Department of Cytogenetics, Chausseestrasse 117, 10115 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrej","family":"Gortchakov","sequence":"additional","affiliation":[{"name":"The Institute of Cytology and Genetics, Lavrentjeva 10, Novosibirsk, 630090, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Saumweber","sequence":"additional","affiliation":[{"name":"Humboldt University Berlin, Institute of Biology, Department of Cytogenetics, Chausseestrasse 117, 10115 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042612590977400_REF1","doi-asserted-by":"crossref","unstructured":"Aagaard, L., Laible, G., Selenko, P., Schmid, M., Dorn, R., Schotta, G., Kuhfittig, S., Wolf, A., Lebersorger, A., Singh, P. 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