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Further study revealed that the \u03b1-subunits capable of binding to midkine were \u03b14 and \u03b16. Purified \u03b14\u03b21- and \u03b16\u03b21-integrins bound midkine. Anti-\u03b14 antibody inhibited the midkine-dependent migration of osteoblastic cells, and anti-\u03b16 antibody inhibited the midkine-dependent neurite outgrowth of embryonic neurons. After midkine treatment, tyrosine phosphorylation of paxillin, an integrin-associated molecule, was transiently increased in osteoblastic cells. Therefore, we concluded that \u03b14\u03b21- and \u03b16\u03b21-integrins are functional receptors for midkine. We observed that the low-density-lipoprotein-receptor-related-protein-6 ectodomain was immunoprecipitated with \u03b16\u03b21-integrin and \u03b14\u03b21-integrin. The low-density-lipoprotein-receptor-related-protein-6 ectodomain was also immunoprecipitated with receptor-type protein tyrosine phosphatase \u03b6. \u03b14\u03b21- and \u03b16\u03b21-Integrins are expected to co-operate with other midkine receptors, possibly in a multimolecular complex that contains other midkine receptors.<\/jats:p>","DOI":"10.1242\/jcs.01423","type":"journal-article","created":{"date-parts":[[2004,10,5]],"date-time":"2004-10-05T21:22:47Z","timestamp":1097011367000},"page":"5405-5415","source":"Crossref","is-referenced-by-count":114,"title":["\u03b14\u03b21- and \u03b16\u03b21-integrins are functional receptors for midkine, a heparin-binding growth factor"],"prefix":"10.1242","volume":"117","author":[{"given":"Hisako","family":"Muramatsu","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Division of Disease Models, Center for Neural Disease and Cancer, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Division of Disease Models, Center for Neural Disease and Cancer, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromichi","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Division of Disease Models, Center for Neural Disease and Cancer, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Oda","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Division of Disease Models, Center for Neural Disease and Cancer, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Yun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Division of Disease Models, Center for Neural Disease and Cancer, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahoko","family":"Sakaguchi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Division of Disease Models, Center for Neural Disease and Cancer, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadatoshi","family":"Sakuma","sequence":"additional","affiliation":[{"name":"Cell Signals, 75-1 Ono-cho, Tsurumi-ku, Yokohama 230-0046, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuaki","family":"Maeda","sequence":"additional","affiliation":[{"name":"Division of Molecular Neurobiology, National Institute for Basic Biology, Myodaiji-cho, Okazaki 444-8585, Japan"},{"name":"Department of Developmental Neuroscience, Tokyo Metropolitan Institute for Neuroscience, 2-6 Musashidai, Fuchu, Tokyo 183-8526, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaharu","family":"Noda","sequence":"additional","affiliation":[{"name":"Division of Molecular Neurobiology, National Institute for Basic Biology, Myodaiji-cho, Okazaki 444-8585, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshikazu","family":"Takada","sequence":"additional","affiliation":[{"name":"University of California Davis Medical Center, 4645 2nd Avenue, Sacramento, CA 95817, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Muramatsu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Division of Disease Models, Center for Neural Disease and Cancer, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042518455043800_REF1","doi-asserted-by":"crossref","unstructured":"Argraves, W. 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