{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:15:25Z","timestamp":1790864125261,"version":"4.1.0"},"reference-count":66,"publisher":"The Company of Biologists","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,2,15]]},"abstract":"<jats:p>Stem cells are cells that, upon division, can produce new stem cells as well as daughter cells that initiate differentiation along a specific lineage. Studies using the Drosophila germline as a model system have demonstrated that signaling from the stem cell niche plays a crucial role in controlling stem cell behavior. Surrounding support cells secrete growth factors that activate signaling within adjacent stem cells to specify stem cell self-renewal and block differentiation. In addition, cell-cell adhesion between stem cells and surrounding support cells is important for holding stem cells close to self-renewal signals. Furthermore, a combination of localized signaling and autonomously acting proteins might polarize stem cells in such a way as to ensure asymmetric stem cell divisions. Recent results describing stem cell niches in other adult stem cells, including hematopoietic and neural stem cells, have demonstrated that the features characteristic of stem cell niches in Drosophila gonads might be conserved.<\/jats:p>","DOI":"10.1242\/jcs.01680","type":"journal-article","created":{"date-parts":[[2005,2,8]],"date-time":"2005-02-08T22:18:22Z","timestamp":1107901102000},"page":"665-672","source":"Crossref","is-referenced-by-count":171,"title":["Signaling in stem cell niches: lessons from the<i>Drosophila<\/i>germline"],"prefix":"10.1242","volume":"118","author":[{"given":"Yukiko M.","family":"Yamashita","sequence":"first","affiliation":[{"name":"Department of Development Biology, Stanford University School of Medicine, Stanford, CA 94305, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret T.","family":"Fuller","sequence":"additional","affiliation":[{"name":"Department of Development Biology, Stanford University School of Medicine, Stanford, CA 94305, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. Leanne","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Development Biology, Stanford University School of Medicine, Stanford, CA 94305, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042519135126100_REF1","doi-asserted-by":"crossref","unstructured":"Aida, M., Beis, D., Heidstra, R., Willemsen, V., Blilou, I., Galinha, C., Nussaume, L., Noh, Y. S., Amasino, R. and Scheres, B. (2004). The PLETHORA genes mediate patterning of the Arabidopsis root stem cell niche. Cell119, 109-120.","DOI":"10.1016\/j.cell.2004.09.018"},{"key":"2021042519135126100_REF2","doi-asserted-by":"crossref","unstructured":"Baurle, I. and Laux, T. (2003). Apical meristems: the plant's fountain of youth. BioEssays25, 961-970.","DOI":"10.1002\/bies.10341"},{"key":"2021042519135126100_REF3","doi-asserted-by":"crossref","unstructured":"Bolivar, J., Huynh, J. R., Lopez-Schier, H., Gonzalez, C., St Johnston, D. and Gonzalez-Reyes, A. (2001). Centrosome migration into the Drosophila oocyte is independent of BicD and egl, and of the organisation of the microtubule cytoskeleton. Development128, 1889-1897.","DOI":"10.1242\/dev.128.10.1889"},{"key":"2021042519135126100_REF4","doi-asserted-by":"crossref","unstructured":"Brawley, C. and Matunis, E. (2004). Regeneration of male germline stem cells by spermatogonial dedifferentiation in vivo. Science304, 1331-1334.","DOI":"10.1126\/science.1097676"},{"key":"2021042519135126100_REF5","doi-asserted-by":"crossref","unstructured":"Calvi, L. M., Adams, G. B., Weibrecht, K. W., Weber, J. M., Olson, D. P., Knight, M. C., Martin, R. P., Schipani, E., Divieti, P., Bringhurst, F. R. et al. (2003). Osteoblastic cells regulate the haematopoietic stem cell niche. Nature425, 841-846.","DOI":"10.1038\/nature02040"},{"key":"2021042519135126100_REF6","doi-asserted-by":"crossref","unstructured":"Casanueva, M. O. and Ferguson, E. L. (2004). Germline stem cell number in the Drosophila ovary is regulated by redundant mechanisms that control Dpp signaling. Development131, 1881-1890.","DOI":"10.1242\/dev.01076"},{"key":"2021042519135126100_REF7","doi-asserted-by":"crossref","unstructured":"Chen, D. and McKearin, D. (2003a). Dpp signaling silences bam transcription directly to establish asymmetric divisions of germline stem cells. Curr. Biol.13, 1786-1791.","DOI":"10.1016\/j.cub.2003.09.033"},{"key":"2021042519135126100_REF8","doi-asserted-by":"crossref","unstructured":"Chen, D. and McKearin, D. M. (2003b). A discrete transcriptional silencer in the bam gene determines asymmetric division of the Drosophila germline stem cell. Development130, 1159-1170.","DOI":"10.1242\/dev.00325"},{"key":"2021042519135126100_REF9","unstructured":"de Cuevas, M., Lee, J. K. and Spradling, A. C. (1996). alpha-spectrin is required for germline cell division and differentiation in the Drosophila ovary. Development122, 3959-3968."},{"key":"2021042519135126100_REF10","doi-asserted-by":"crossref","unstructured":"Deng, W. and Lin, H. (1997). Spectrosomes and fusomes anchor mitotic spindles during asymmetric germ cell divisions and facilitate the formation of a polarized microtubule array for oocyte specification in Drosophila.Dev. Biol.189, 79-94.","DOI":"10.1006\/dbio.1997.8669"},{"key":"2021042519135126100_REF11","doi-asserted-by":"crossref","unstructured":"Doetsch, F., Caille, I., Lim, D. A., Garcia-Verdugo, J. M. and Alvarez-Buylla, A. (1999). Subventricular zone astrocytes are neural stem cells in the adult mammalian brain. Cell97, 703-716.","DOI":"10.1016\/S0092-8674(00)80783-7"},{"key":"2021042519135126100_REF12","doi-asserted-by":"crossref","unstructured":"Fuchs, E., Tumbar, T. and Guasch, G. (2004). Socializing with the neighbors: stem cells and their niche. Cell116, 769-778.","DOI":"10.1016\/S0092-8674(04)00255-7"},{"key":"2021042519135126100_REF13","doi-asserted-by":"crossref","unstructured":"Gage, F. H. (2000). Mammalian neural stem cells. Science287, 1433-1438.","DOI":"10.1126\/science.287.5457.1433"},{"key":"2021042519135126100_REF14","doi-asserted-by":"crossref","unstructured":"Gilboa, L., Forbes, A., Tazuke, S. I., Fuller, M. T. and Lehmann, R. (2003). Germ line stem cell differentiation in Drosophila requires gap junctions and proceeds via an intermediate state. Development130, 6625-6634.","DOI":"10.1242\/dev.00853"},{"key":"2021042519135126100_REF15","doi-asserted-by":"crossref","unstructured":"Gonzalez-Reyes, A. (2003). Stem cells, niches and cadherins: a view from Drosophila.J. Cell Sci.116, 949-954.","DOI":"10.1242\/jcs.00310"},{"key":"2021042519135126100_REF16","doi-asserted-by":"crossref","unstructured":"Harrison, D. A., McCoon, P. E., Binari, R., Gilman, M. and Perrimon, N. (1998). Drosophila unpaired encodes a secreted protein that activates the JAK signaling pathway. Genes Dev.12, 3252-3263.","DOI":"10.1101\/gad.12.20.3252"},{"key":"2021042519135126100_REF17","doi-asserted-by":"crossref","unstructured":"Jones, D. L. and Fuller, M. T. (2004). Stem cell niches. In Handbook of Stem Cells, Vol. 1: Adult and Fetal Stem Cells (ed. R. Lanza), pp. 59-72.San Diego, CA: Academic Press.","DOI":"10.1016\/B978-012436643-5\/50095-X"},{"key":"2021042519135126100_REF18","unstructured":"Jones, L. (2001). Stem cells: so what's in a niche? Curr. Biol.11, R484-486."},{"key":"2021042519135126100_REF19","doi-asserted-by":"crossref","unstructured":"Kai, T. and Spradling, A. (2003). An empty Drosophila stem cell niche reactivates the proliferation of ectopic cells. Proc. Natl. Acad. Sci. USA100, 4633-4638.","DOI":"10.1073\/pnas.0830856100"},{"key":"2021042519135126100_REF20","doi-asserted-by":"crossref","unstructured":"Kai, T. and Spradling, A. (2004). Differentiating germ cells can revert into functional stem cells in Drosophila melanogaster ovaries. Nature428, 564-569.","DOI":"10.1038\/nature02436"},{"key":"2021042519135126100_REF21","doi-asserted-by":"crossref","unstructured":"Kawase, E., Wong, M. D., Ding, B. C. and Xie, T. (2004). Gbb\/Bmp signaling is essential for maintaining germline stem cells and for repressing bam transcription in the Drosophila testis. Development131, 1365-1375.","DOI":"10.1242\/dev.01025"},{"key":"2021042519135126100_REF22","doi-asserted-by":"crossref","unstructured":"Kiger, A. A., White-Cooper, H. and Fuller, M. T. (2000). Somatic support cells restrict germline stem cell self-renewal and promote differentiation. Nature407, 750-754.","DOI":"10.1038\/35037606"},{"key":"2021042519135126100_REF23","doi-asserted-by":"crossref","unstructured":"Kiger, A. A., Jones, D. L., Schulz, C., Rogers, M. B. and Fuller, M. T. (2001). Stem cell self-renewal specified by JAK-STAT activation in response to a support cell cue. Science294, 2542-2545.","DOI":"10.1126\/science.1066707"},{"key":"2021042519135126100_REF24","doi-asserted-by":"crossref","unstructured":"Klambt, C. (2002). EGF receptor signalling: roles of star and rhomboid revealed. Curr. Biol.12, R21-23.","DOI":"10.1016\/S0960-9822(01)00642-X"},{"key":"2021042519135126100_REF25","doi-asserted-by":"crossref","unstructured":"Kuhn, H. G., Winkler, J., Kempermann, G., Thal, L. J. and Gage, F. H. (1997). Epidermal growth factor and fibroblast growth factor-2 have different effects on neural progenitors in the adult rat brain. J. Neurosci.17, 5820-5829.","DOI":"10.1523\/JNEUROSCI.17-15-05820.1997"},{"key":"2021042519135126100_REF26","doi-asserted-by":"crossref","unstructured":"Lim, D. A. and Alvarez-Buylla, A. (1999). Interaction between astrocytes and adult subventricular zone precursors stimulates neurogenesis. Proc. Natl. Acad. Sci. USA96, 7526-7531.","DOI":"10.1073\/pnas.96.13.7526"},{"key":"2021042519135126100_REF27","doi-asserted-by":"crossref","unstructured":"Lin, H. (2002). The stem-cell niche theory: lessons from flies. Nat. Rev. Genet.3, 931-940.","DOI":"10.1038\/nrg952"},{"key":"2021042519135126100_REF28","doi-asserted-by":"crossref","unstructured":"Lin, H., Yue, L. and Spradling, A. C. (1994). The Drosophila fusome, a germline-specific organelle, contains membrane skeletal proteins and functions in cyst formation. Development120, 947-956.","DOI":"10.1242\/dev.120.4.947"},{"key":"2021042519135126100_REF29","doi-asserted-by":"crossref","unstructured":"Matunis, E., Tran, J., Gonczy, P., Caldwell, K. and DiNardo, S. (1997). punt and schnurri regulate a somatically derived signal that restricts proliferation of committed progenitors in the germline. Development124, 4383-4391.","DOI":"10.1242\/dev.124.21.4383"},{"key":"2021042519135126100_REF30","doi-asserted-by":"crossref","unstructured":"Morris, R. J., Liu, Y., Marles, L., Yang, Z., Trempus, C., Li, S., Lin, J. S., Sawicki, J. A. and Cotsarelis, G. (2004). Capturing and profiling adult hair follicle stem cells. Nat. Biotechnol.22, 411-417.","DOI":"10.1038\/nbt950"},{"key":"2021042519135126100_REF31","doi-asserted-by":"crossref","unstructured":"Moustakas, A. (2002). Smad signalling network. J. Cell Sci.115, 3355-3356.","DOI":"10.1242\/jcs.115.17.3355"},{"key":"2021042519135126100_REF32","doi-asserted-by":"crossref","unstructured":"Nelson, W. J. and Nusse, R. (2004). Convergence of Wnt, beta-catenin, and cadherin pathways. Science303, 1483-1487.","DOI":"10.1126\/science.1094291"},{"key":"2021042519135126100_REF33","doi-asserted-by":"crossref","unstructured":"Ohlstein, B. and McKearin, D. (1997). Ectopic expression of the Drosophila Bam protein eliminates oogenic germline stem cells. Development124, 3651-3662.","DOI":"10.1242\/dev.124.18.3651"},{"key":"2021042519135126100_REF34","doi-asserted-by":"crossref","unstructured":"Ohlstein, B., Kai, T., Decotto, E. and Spradling, A. (2004). The stem cell niche: theme and variations. Curr. Opin. Cell Biol.16, 693-699.","DOI":"10.1016\/j.ceb.2004.09.003"},{"key":"2021042519135126100_REF35","doi-asserted-by":"crossref","unstructured":"Pevny, L. and Rao, M. S. (2003). The stem-cell menagerie. Trends Neurosci.26, 351-359.","DOI":"10.1016\/S0166-2236(03)00169-3"},{"key":"2021042519135126100_REF36","doi-asserted-by":"crossref","unstructured":"Rawlings, J. S., Rosler, K. M. and Harrison, D. A. (2004). The JAK\/STAT signaling pathway. J. Cell Sci.117, 1281-1283.","DOI":"10.1242\/jcs.00963"},{"key":"2021042519135126100_REF37","doi-asserted-by":"crossref","unstructured":"Reya, T., Duncan, A. W., Ailles, L., Domen, J., Scherer, D. C., Willert, K., Hintz, L., Nusse, R. and Weissman, I. L. (2003). A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature423, 409-414.","DOI":"10.1038\/nature01593"},{"key":"2021042519135126100_REF38","doi-asserted-by":"crossref","unstructured":"Reynolds, B. A. and Weiss, S. (1992). Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. Science255, 1707-1710.","DOI":"10.1126\/science.1553558"},{"key":"2021042519135126100_REF39","doi-asserted-by":"crossref","unstructured":"Sabatini, S., Heidstra, R., Wildwater, M. and Scheres, B. (2003). SCARECROW is involved in positioning the stem cell niche in the Arabidopsis root meristem. Genes Dev.17, 354-358.","DOI":"10.1101\/gad.252503"},{"key":"2021042519135126100_REF40","doi-asserted-by":"crossref","unstructured":"Sanai, N., Tramontin, A. D., Quinones-Hinojosa, A., Barbaro, N. M., Gupta, N., Kunwar, S., Lawton, M. T., McDermott, M. W., Parsa, A. T., Manuel-Garcia Verdugo, J. et al. (2004). Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration. Nature427, 740-744.","DOI":"10.1038\/nature02301"},{"key":"2021042519135126100_REF41","unstructured":"Schulz, C., Wood, C. G., Jones, D. L., Tazuke, S. I. and Fuller, M. T. (2002). Signaling from germ cells mediated by the rhomboid homolog stet organizes encapsulation by somatic support cells. Development129, 4523-4534."},{"key":"2021042519135126100_REF42","doi-asserted-by":"crossref","unstructured":"Schulz, C., Kiger, A. A., Tazuke, S. I., Yamashita, Y. M., Pantalena-Filho, L. C., Jones, D. L., Wood, C. G. and Fuller, M. T. (2004). A misexpression screen reveals effects of bag-of-marbles and TGFbeta class signaling on the Drosophila male germ-line stem cell lineage. Genetics167, 707-723.","DOI":"10.1534\/genetics.103.023184"},{"key":"2021042519135126100_REF43","doi-asserted-by":"crossref","unstructured":"Shen, Q., Goderie, S. K., Jin, L., Karanth, N., Sun, Y., Abramova, N., Vincent, P., Pumiglia, K. and Temple, S. (2004). Endothelial cells stimulate self-renewal and expand neurogenesis of neural stem cells. Science304, 1338-1340.","DOI":"10.1126\/science.1095505"},{"key":"2021042519135126100_REF44","doi-asserted-by":"crossref","unstructured":"Shivdasani, A. A. and Ingham, P. W. (2003). Regulation of stem cell maintenance and transit amplifying cell proliferation by TGF-beta signaling in Drosophila spermatogenesis. Curr. Biol.13, 2065-2072.","DOI":"10.1016\/j.cub.2003.10.063"},{"key":"2021042519135126100_REF45","doi-asserted-by":"crossref","unstructured":"Song, H., Stevens, C. F. and Gage, F. H. (2002a). Astroglia induce neurogenesis from adult neural stem cells. Nature417, 39-44.","DOI":"10.1038\/417039a"},{"key":"2021042519135126100_REF46","doi-asserted-by":"crossref","unstructured":"Song, H. J., Stevens, C. F. and Gage, F. H. (2002b). Neural stem cells from adult hippocampus develop essential properties of functional CNS neurons. Nat. Neurosci.5, 438-445.","DOI":"10.1038\/nn844"},{"key":"2021042519135126100_REF47","doi-asserted-by":"crossref","unstructured":"Song, X., Zhu, C. H., Doan, C. and Xie, T. (2002). Germline stem cells anchored by adherens junctions in the Drosophila ovary niches. Science296, 1855-1857.","DOI":"10.1126\/science.1069871"},{"key":"2021042519135126100_REF48","doi-asserted-by":"crossref","unstructured":"Song, X., Wong, M. D., Kawase, E., Xi, R., Ding, B. C., McCarthy, J. J. and Xie, T. (2004). Bmp signals from niche cells directly repress transcription of a differentiation-promoting gene, bag of marbles, in germline stem cells in the Drosophila ovary. Development131, 1353-1364.","DOI":"10.1242\/dev.01026"},{"key":"2021042519135126100_REF49","doi-asserted-by":"crossref","unstructured":"Taupin, P., Ray, J., Fischer, W. H., Suhr, S. T., Hakansson, K., Grubb, A. and Gage, F. H. (2000). FGF-2-responsive neural stem cell proliferation requires CCg, a novel autocrine\/paracrine cofactor. Neuron28, 385-397.","DOI":"10.1016\/S0896-6273(00)00119-7"},{"key":"2021042519135126100_REF50","doi-asserted-by":"crossref","unstructured":"Tazuke, S. I., Schulz, C., Gilboa, L., Fogarty, M., Mahowald, A. P., Guichet, A., Ephrussi, A., Wood, C. G., Lehmann, R. and Fuller, M. T. (2002). A germline-specific gap junction protein required for survival of differentiating early germ cells. Development129, 2529-2539.","DOI":"10.1242\/dev.129.10.2529"},{"key":"2021042519135126100_REF51","doi-asserted-by":"crossref","unstructured":"Tran, J., Brenner, T. J. and DiNardo, S. (2000). Somatic control over the germline stem cell lineage during Drosophila spermatogenesis. Nature407, 754-757.","DOI":"10.1038\/35037613"},{"key":"2021042519135126100_REF52","doi-asserted-by":"crossref","unstructured":"Tulina, N. and Matunis, E. (2001). Control of stem cell self-renewal in Drosophila spermatogenesis by JAK-STAT signaling. Science294, 2546-2549.","DOI":"10.1126\/science.1066700"},{"key":"2021042519135126100_REF53","doi-asserted-by":"crossref","unstructured":"Tumbar, T., Guasch, G., Greco, V., Blanpain, C., Lowry, W. E., Rendl, M. and Fuchs, E. (2004). Defining the epithelial stem cell niche in skin. Science303, 359-363.","DOI":"10.1126\/science.1092436"},{"key":"2021042519135126100_REF54","doi-asserted-by":"crossref","unstructured":"Uchida, N., Buck, D. W., He, D., Reitsma, M. J., Masek, M., Phan, T. V., Tsukamoto, A. S., Gage, F. H. and Weissman, I. L. (2000). Direct isolation of human central nervous system stem cells. Proc. Natl. Acad. Sci. USA97, 14720-14725.","DOI":"10.1073\/pnas.97.26.14720"},{"key":"2021042519135126100_REF55","doi-asserted-by":"crossref","unstructured":"Urban, S., Lee, J. R. and Freeman, M. (2001). Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases. Cell107, 173-182.","DOI":"10.1016\/S0092-8674(01)00525-6"},{"key":"2021042519135126100_REF56","doi-asserted-by":"crossref","unstructured":"van den Berg, C., Willemsen, V., Hage, W., Weisbeek, P. and Scheres, B. (1995). Cell fate in the Arabidopsis root meristem determined by directional signalling. Nature378, 62-65.","DOI":"10.1038\/378062a0"},{"key":"2021042519135126100_REF57","unstructured":"Wagers, A. J., Allsopp, R. C. and Weissman, I. L. (2002). Changes in integrin expression are associated with altered homing properties of Lin(-\/lo)Thy1.1(lo)Sca-1(+)c-kit(+) hematopoietic stem cells following mobilization by cyclophosphamide\/granulocyte colony-stimulating factor. Exp. Hematol.30, 176-185."},{"key":"2021042519135126100_REF58","doi-asserted-by":"crossref","unstructured":"Wagner, J. P., Black, I. B. and DiCicco-Bloom, E. (1999). Stimulation of neonatal and adult brain neurogenesis by subcutaneous injection of basic fibroblast growth factor. J. Neurosci.19, 6006-6016.","DOI":"10.1523\/JNEUROSCI.19-14-06006.1999"},{"key":"2021042519135126100_REF59","doi-asserted-by":"crossref","unstructured":"Watt, F. M. and Hogan, B. L. (2000). Out of Eden: stem cells and their niches. Science287, 1427-1430.","DOI":"10.1126\/science.287.5457.1427"},{"key":"2021042519135126100_REF60","doi-asserted-by":"crossref","unstructured":"Willert, K., Brown, J. D., Danenberg, E., Duncan, A. W., Weissman, I. L., Reya, T., Yates, J. R., III and Nusse, R. (2003). Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature423, 448-452.","DOI":"10.1038\/nature01611"},{"key":"2021042519135126100_REF61","doi-asserted-by":"crossref","unstructured":"Wright, D. E., Wagers, A. J., Gulati, A. P., Johnson, F. L. and Weissman, I. L. (2001). Physiological migration of hematopoietic stem and progenitor cells. Science294, 1933-1936.","DOI":"10.1126\/science.1064081"},{"key":"2021042519135126100_REF62","doi-asserted-by":"crossref","unstructured":"Wurmser, A. E., Nakashima, K., Summers, R. G., Toni, N., D'Amour, K. A., Lie, D. C. and Gage, F. H. (2004). Cell fusion-independent differentiation of neural stem cells to the endothelial lineage. Nature430, 350-356.","DOI":"10.1038\/nature02604"},{"key":"2021042519135126100_REF63","doi-asserted-by":"crossref","unstructured":"Xie, T. and Spradling, A. C. (1998). decapentaplegic is essential for the maintenance and division of germline stem cells in the Drosophila ovary. Cell94, 251-260.","DOI":"10.1016\/S0092-8674(00)81424-5"},{"key":"2021042519135126100_REF64","doi-asserted-by":"crossref","unstructured":"Xie, T. and Spradling, A. C. (2000). A niche maintaining germ line stem cells in the Drosophila ovary. Science290, 328-330.","DOI":"10.1126\/science.290.5490.328"},{"key":"2021042519135126100_REF65","doi-asserted-by":"crossref","unstructured":"Yamashita, Y., Jones, D. L. and Fuller, M. T. (2003). Orientation of asymmetric stem cell division by the APC tumor suppressor and centrosome. Science301, 1547-1550.","DOI":"10.1126\/science.1087795"},{"key":"2021042519135126100_REF66","doi-asserted-by":"crossref","unstructured":"Zhang, J., Niu, C., Ye, L., Huang, H., He, X., Tong, W. G., Ross, J., Haug, J., Johnson, T., Feng, J. Q. et al. (2003). Identification of the haematopoietic stem cell niche and control of the niche size. Nature425, 836-841.","DOI":"10.1038\/nature02041"}],"container-title":["Journal of Cell Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.biologists.com\/jcs\/article-pdf\/118\/4\/665\/1522102\/665.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/journals.biologists.com\/jcs\/article-pdf\/118\/4\/665\/1522102\/665.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T02:49:31Z","timestamp":1682995771000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/jcs\/article\/118\/4\/665\/28694\/Signaling-in-stem-cell-niches-lessons-from-the"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,2,15]]},"references-count":66,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,2,15]]}},"URL":"https:\/\/doi.org\/10.1242\/jcs.01680","relation":{},"ISSN":["1477-9137","0021-9533"],"issn-type":[{"value":"1477-9137","type":"electronic"},{"value":"0021-9533","type":"print"}],"subject":[],"published":{"date-parts":[[2005,2,15]]}}}