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In addition, other receptors, channels and membrane proteins, such as gap junction hemichannels, metabotropic glutamate receptors, HERG K+ channels and the receptor Notch, are all sensitive to external [Ca2+] fluctuations. A recently cloned Ca2+ sensor (CAS) in Arabidopsis extends this concept to the plant kingdom. Emerging evidence indicates that [Ca2+] in the local microenvironment outside the cell undergoes alterations potentially sufficient to exert biological actions through these sensor proteins. The extracellular space might therefore constitute a much more dynamic Ca2+ signaling compartment than previously appreciated.<\/jats:p>","DOI":"10.1242\/jcs.01705","type":"journal-article","created":{"date-parts":[[2005,2,24]],"date-time":"2005-02-24T02:18:06Z","timestamp":1109211486000},"page":"855-862","source":"Crossref","is-referenced-by-count":93,"title":["Another dimension to calcium signaling: a look at extracellular calcium"],"prefix":"10.1242","volume":"118","author":[{"given":"Aldebaran M.","family":"Hofer","sequence":"first","affiliation":[{"name":"VA Boston Healthcare System and Brigham & Women's Hospital, Department of Surgery, Harvard Medical School, 1400 VFW Parkway, West Roxbury, MA 02132, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","reference":[{"key":"2021042519183939900_REF1","doi-asserted-by":"crossref","unstructured":"Allen, G. J., Chu, S. P., Harrington, C. L., Schumacher, K., Hoffmann, T.,\n          Tang, Y. 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