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Periodic Ca2+ oscillations are synchronised between physically contacting myofibroblasts and become desynchronised upon dissociation of adherens junctions with function-blocking peptides. Similar uncoupling is obtained by inhibiting myofibroblast contraction using myosin inhibitors and by blocking mechanosensitive ion channels using Gd3+ and GSMTx4. By contrast, gap junction uncouplers do not affect myofibroblast coordination. We propose the following model of mechanical coupling for myofibroblasts: individual cell contraction is transmitted via adherens junctions and leads to the opening of mechanosensitive ion channels in adjacent cells. The resulting Ca2+ influx induces a contraction that can feed back on the first cell and\/or stimulate other contacting cells. This mechanism could improve the remodelling of cell-dense tissue by coordinating the activity of myofibroblasts.<\/jats:p>","DOI":"10.1242\/jcs.024521","type":"journal-article","created":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T02:53:47Z","timestamp":1222829627000},"page":"3305-3316","source":"Crossref","is-referenced-by-count":115,"title":["Myofibroblast communication is controlled by intercellular mechanical coupling"],"prefix":"10.1242","volume":"121","author":[{"given":"Lysianne","family":"Follonier","sequence":"first","affiliation":[{"name":"Laboratory of Cell Biophysics, Ecole Polytechnique Fe\u0301de\u0301rale de Lausanne (EPFL), Ba\u0302timent SG\u2013AA-B143, Station 15, CH-1015 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se\u0301bastien","family":"Schaub","sequence":"additional","affiliation":[{"name":"CNRS-UMR 6543, Centre A. 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