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We further show that in up to 70% of the cases exocytosis does not result in significant release of the peptide cargo, likely because of a mechanism that leads to premature closure of the fusion pore. Release of nucleotides and protons occurred regardless of whether peptides were secreted or not. These observations suggest that insulin-secreting cells are able to use the same secretory vesicles to release small molecules either alone or together with the peptide hormone.<\/jats:p>","DOI":"10.1242\/jcs.02549","type":"journal-article","created":{"date-parts":[[2005,9,3]],"date-time":"2005-09-03T00:13:21Z","timestamp":1125706401000},"page":"4271-4282","source":"Crossref","is-referenced-by-count":127,"title":["Selective nucleotide-release from dense-core granules in insulin-secreting cells"],"prefix":"10.1242","volume":"118","author":[{"given":"Stefanie","family":"Obermu\u0308ller","sequence":"first","affiliation":[{"name":"Department of Experimental Medicinal Sciences, Lund University, BMC B11, SE-221 84 Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Lindqvist","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicinal Sciences, Lund University, BMC B11, SE-221 84 Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jovita","family":"Karanauskaite","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicinal Sciences, Lund University, BMC B11, SE-221 84 Lund, Sweden"},{"name":"OCDEM, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Oxford, OX3 7LJ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juris","family":"Galvanovskis","sequence":"additional","affiliation":[{"name":"OCDEM, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Oxford, OX3 7LJ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrik","family":"Rorsman","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicinal Sciences, Lund University, BMC B11, SE-221 84 Lund, Sweden"},{"name":"OCDEM, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Oxford, OX3 7LJ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Barg","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicinal Sciences, Lund University, BMC B11, SE-221 84 Lund, Sweden"},{"name":"Vollum Institute, Oregon Health and Sciences University, 3181 SW Sam Jackson Park Road, Portland OR, 97210, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042519130174600_REF1","doi-asserted-by":"crossref","unstructured":"Albillos, A., Dernick, G., Horstmann, H., Almers, W., Alvarez de Toledo, G. and Lindau, M. 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