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We used N-terminal deletion constructs to narrow the domain necessary for cilia trafficking to the first 15 amino acids of PC2 and identified a conserved motif, R6VxP, that is required for cilial localization. The N-terminal 15 amino acids are also sufficient to localize heterologous proteins in cilia. PC2 has endogenous cilia trafficking information and is present in cilia of cells lining cysts that result from mutations in PKD1.<\/jats:p>","DOI":"10.1242\/jcs.02818","type":"journal-article","created":{"date-parts":[[2006,3,14]],"date-time":"2006-03-14T21:33:27Z","timestamp":1142372007000},"page":"1383-1395","source":"Crossref","is-referenced-by-count":262,"title":["Polycystin-2 traffics to cilia independently of polycystin-1 by using an N-terminal RVxP motif"],"prefix":"10.1242","volume":"119","author":[{"given":"Lin","family":"Geng","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dayne","family":"Okuhara","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiheng","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqiang","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sekiya","family":"Shibazaki","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Somlo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA"},{"name":"Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA"},{"name":"Section of Nephrology, Yale University School of Medicine, P.O. 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