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Co-immunoprecipitation with specific BNIP-H antibody confirmed that endogenous BNIP-H and KGA form a physiological complex in the brain, whereas binding studies showed that they interact with each other directly. Immunohistochemistry and in situ hybridisation revealed high BNIP-H expression in hippocampus and cerebellum, broadly overlapping with the expression pattern previously reported for KGA. Significantly, BNIP-H expression was activated in differentiating neurons of the embryonic carcinoma cell line P19 whereas its overexpression in rat pheochromocytoma PC12 cells relocalised KGA from the mitochondria to neurite terminals. It also reduced the steady-state levels of glutamate by inhibiting KGA enzyme activity. These results strongly suggest that through binding to KGA, BNIP-H could regulate glutamate synthesis at synapses during neurotransmission. Thus, loss of BNIP-H function could render glutamate excitotoxicity or\/and deregulated glutamatergic activation, leading to ataxia, dystonia or other neurological disorders.<\/jats:p>","DOI":"10.1242\/jcs.03061","type":"journal-article","created":{"date-parts":[[2006,8,9]],"date-time":"2006-08-09T22:13:09Z","timestamp":1155161589000},"page":"3337-3350","source":"Crossref","is-referenced-by-count":60,"title":["Brain-specific BNIP-2-homology protein Caytaxin relocalises glutaminase to neurite terminals and reduces glutamate levels"],"prefix":"10.1242","volume":"119","author":[{"given":"Jan Paul","family":"Buschdorf","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, 14 Science Drive 4, Faculty of Science, National University of Singapore, Singapore 117543, Republic of Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li Chew","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, 14 Science Drive 4, Faculty of Science, National University of Singapore, Singapore 117543, Republic of Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Yong Loo Lin School of Medicine, 4 Medical Drive, National University of Singapore, Singapore 117597, Republic of Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Yong Loo Lin School of Medicine, 4 Medical Drive, National University of Singapore, Singapore 117597, Republic of Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng-Yi","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Yong Loo Lin School of Medicine, 4 Medical Drive, National University of Singapore, Singapore 117597, Republic of Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yih-Cherng","family":"Liou","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, 14 Science Drive 4, Faculty of Science, National University of Singapore, Singapore 117543, Republic of Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi Ting","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, 14 Science Drive 4, Faculty of Science, National University of Singapore, Singapore 117543, Republic of Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boon Chuan","family":"Low","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, 14 Science Drive 4, Faculty of Science, National University of Singapore, Singapore 117543, Republic of Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042519285968400_REF1","doi-asserted-by":"crossref","unstructured":"Aledo, J. 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