{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T08:59:03Z","timestamp":1790499543178,"version":"4.1.0"},"reference-count":27,"publisher":"The Company of Biologists","issue":"17","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,9,1]]},"abstract":"<jats:p>Desmocollin 3 (DSC3) belongs to a subfamily of cadherins and is a major component of desmosomes in keratinocytes of stratified epithelia, such as the epidermis. Based on its amino acid sequence homology to classical cadherins, such as E-cadherin, it has been postulated that DSC3 functions as a cell-adhesion molecule. To test this hypothesis, we assessed the function of DSC3 in the development and maintenance of stratified epithelia, in particular the epidermis and hair follicles. Using a conditional null allele, we show that loss of Dsc3 function in the epidermis causes impaired cell\u2013cell adhesion, leading to intra-epidermal blistering and telogen hair loss. Furthermore, the lesions in Dsc3-null skin resemble those observed in individuals with pemphigus vulgaris (PV), indicating that impaired Dsc3 function could be a potential cause of PV-like inherited or acquired skin blistering diseases.<\/jats:p>","DOI":"10.1242\/jcs.031518","type":"journal-article","created":{"date-parts":[[2008,8,5]],"date-time":"2008-08-05T23:48:48Z","timestamp":1217980128000},"page":"2844-2849","source":"Crossref","is-referenced-by-count":93,"title":["Loss of desmocollin 3 in mice leads to epidermal blistering"],"prefix":"10.1242","volume":"121","author":[{"given":"Jiangli","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Dermatology, Charles C. Gates Regenerative Medicine and Stem Cell Biology Program, University of Colorado Denver, Aurora, CO 80045, USA"},{"name":"Department of Dermatology, Baylor College of Medicine, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhining","family":"Den","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Baylor College of Medicine, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Koch","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Charles C. Gates Regenerative Medicine and Stem Cell Biology Program, University of Colorado Denver, Aurora, CO 80045, USA"},{"name":"Department of Dermatology, Baylor College of Medicine, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042520213954200_REF1","unstructured":"Amagai, M., Ahmed, A. R., Kitajima, Y., Bystryn, J. C., Milner, Y., Gniadecki, R., Hertl, M., Pincelli, C., Kurzen, H., Fridkis-Hareli, M. et al. (2006). Are desmoglein autoantibodies essential for the immunopathogenesis of pemphigus vulgaris, or just \u201cwitnesses of disease\u201d? Exp. Dermatol.15, 815-831."},{"key":"2021042520213954200_REF2","doi-asserted-by":"crossref","unstructured":"Bolling, M. C., Mekkes, J. R., Goldschmidt, W. F., van Noesel, C. J., Jonkman, M. F. and Pas, H. H. (2007). Acquired palmoplantar keratoderma and immunobullous disease associated with antibodies to desmocollin 3. Br. J. Dermatol.157, 168-173.","DOI":"10.1111\/j.1365-2133.2007.07920.x"},{"key":"2021042520213954200_REF3","doi-asserted-by":"crossref","unstructured":"Bonne, S., Gilbert, B., Hatzfeld, M., Chen, X., Green, K. J. and van Roy, F. (2003). Defining desmosomal plakophilin-3 interactions. J. 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Mice lacking desmocollin 1 show epidermal fragility accompanied by barrier defects and abnormal differentiation. J. Cell Biol.155, 821-832.","DOI":"10.1083\/jcb.200105009"},{"key":"2021042520213954200_REF7","doi-asserted-by":"crossref","unstructured":"Chidgey, M. A., Yue, K. K., Gould, S., Byrne, C. and Garrod, D. R. (1997). Changing pattern of desmocollin 3 expression accompanies epidermal organisation during skin development. Dev. Dyn.210, 315-327.","DOI":"10.1002\/(SICI)1097-0177(199711)210:3<315::AID-AJA11>3.0.CO;2-9"},{"key":"2021042520213954200_REF8","doi-asserted-by":"crossref","unstructured":"Chitaev, N. A. and Troyanovsky, S. M. (1997). Direct Ca2+-dependent heterophilic interaction between desmosomal cadherins, desmoglein and desmocollin, contributes to cell-cell adhesion. J. Cell Biol.138, 193-201.","DOI":"10.1083\/jcb.138.1.193"},{"key":"2021042520213954200_REF9","doi-asserted-by":"crossref","unstructured":"Den, Z., Cheng, X., Merched-Sauvage, M. and Koch, P. J. (2006). 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Intermediate filament-membrane attachments function synergistically with actin-dependent contacts to regulate intercellular adhesive strength. J. Cell Biol.159, 1005-1017.","DOI":"10.1083\/jcb.200206098"},{"key":"2021042520213954200_REF13","doi-asserted-by":"crossref","unstructured":"Ihrie, R. A. and Attardi, L. D. (2005). A new Perp in the lineup: linking p63 and desmosomal adhesion. Cell Cycle4, 873-876.","DOI":"10.4161\/cc.4.7.1836"},{"key":"2021042520213954200_REF14","doi-asserted-by":"crossref","unstructured":"King, I. A., Angst, B. D., Hunt, D. M., Kruger, M., Arnemann, J. and Buxton, R. S. (1997). Hierarchical expression of desmosomal cadherins during stratified epithelial morphogenesis in the mouse. Differentiation62, 83-96.","DOI":"10.1046\/j.1432-0436.1997.6220083.x"},{"key":"2021042520213954200_REF15","doi-asserted-by":"crossref","unstructured":"Koch, P. J., Goldschmidt, M. D., Zimbelmann, R., Troyanovsky, R. and Franke, W. W. (1992). 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