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Under unchallenged conditions, XPC is continuously exported from and imported into the nucleus, which is impeded when NER lesions are present. XPC is omnipresent in the nucleus, allowing a quick response to genotoxic stress. To avoid excessive DNA probing by the low specificity of the protein, the steady-state level in the nucleus is controlled by nucleus-cytoplasm shuttling, allowing temporally higher concentrations of XPC in the nucleus under genotoxic stress conditions.<\/jats:p>","DOI":"10.1242\/jcs.031708","type":"journal-article","created":{"date-parts":[[2008,8,6]],"date-time":"2008-08-06T03:48:48Z","timestamp":1217994528000},"page":"2850-2859","source":"Crossref","is-referenced-by-count":114,"title":["Versatile DNA damage detection by the global genome nucleotide excision repair protein XPC"],"prefix":"10.1242","volume":"121","author":[{"given":"Deborah","family":"Hoogstraten","sequence":"first","affiliation":[{"name":"Department of Cell Biology and Genetics, Erasmus MC Rotterdam, P.O. 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