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This is the first demonstration that a protein can utilise both MT-inhibited and MT-facilitated import mechanisms, and can switch between these different modes of MT interaction to regulate its nuclear trafficking. Importantly, we show that the P-protein exploits MT-dependent mechanisms to manipulate host cell processes by switching the import of the interferon-activated transcription factor STAT1 from a conventional to a MT-inhibited mechanism. This prevents STAT1 nuclear import and signalling in response to interferon, which is vital to the host innate antiviral response. This is the first report of MT involvement in the viral subversion of interferon signalling that is central to virus pathogenicity, and identifies novel targets for the development of antiviral drugs or attenuated viruses for vaccine applications.<\/jats:p>","DOI":"10.1242\/jcs.045542","type":"journal-article","created":{"date-parts":[[2009,9,23]],"date-time":"2009-09-23T01:42:27Z","timestamp":1253670147000},"page":"3652-3662","source":"Crossref","is-referenced-by-count":77,"title":["Dual modes of rabies P-protein association with microtubules: a novel strategy to suppress the antiviral response"],"prefix":"10.1242","volume":"122","author":[{"given":"Gregory W.","family":"Moseley","sequence":"first","affiliation":[{"name":"Nuclear Signalling Laboratory, Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Lahaye","sequence":"additional","affiliation":[{"name":"Laboratoire de Virologie Mole\u0301culaire et Structurale, UMR-CNRS 2472\/UMR-INRA 1157, CNRS, Alle\u0301e de la terrasse, 91198 Gif sur Yvette, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela M.","family":"Roth","sequence":"additional","affiliation":[{"name":"Nuclear Signalling Laboratory, Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sibil","family":"Oksayan","sequence":"additional","affiliation":[{"name":"Nuclear Signalling Laboratory, Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard P.","family":"Filmer","sequence":"additional","affiliation":[{"name":"Nuclear Signalling Laboratory, Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin L.","family":"Rowe","sequence":"additional","affiliation":[{"name":"Nuclear Signalling Laboratory, Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Blondel","sequence":"additional","affiliation":[{"name":"Laboratoire de Virologie Mole\u0301culaire et Structurale, UMR-CNRS 2472\/UMR-INRA 1157, CNRS, Alle\u0301e de la terrasse, 91198 Gif sur Yvette, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Jans","sequence":"additional","affiliation":[{"name":"Nuclear Signalling Laboratory, Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042520580566900_REF1","doi-asserted-by":"crossref","unstructured":"Alvisi, G., Jans, D. 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