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Depletion of Rab7b or expression of Rab7b T22N, a Rab7b dominant-negative mutant, impairs cathepsin-D maturation and causes increased secretion of hexosaminidase. Moreover, expression of Rab7b T22N or depletion of Rab7b alters TGN46 distribution, cation-independent mannose-6-phosphate receptor (CI-MPR) trafficking, and causes an increase in the levels of the late endosomal markers CI-MPR and cathepsin D. Vesicular stomatitis virus G protein (VSV-G) trafficking, by contrast, is normal in Rab7b-depleted or Rab7b-T22N-expressing cells. In addition, depletion of Rab7b prevents cholera toxin B-subunit from reaching the Golgi. Altogether, these data indicate that Rab7b is required for normal lysosome function, and, in particular, that it is an essential factor for retrograde transport from endosomes to the trans-Golgi network (TGN).<\/jats:p>","DOI":"10.1242\/jcs.051474","type":"journal-article","created":{"date-parts":[[2010,4,8]],"date-time":"2010-04-08T00:26:09Z","timestamp":1270686369000},"page":"1480-1491","source":"Crossref","is-referenced-by-count":120,"title":["Rab7b controls trafficking from endosomes to the TGN"],"prefix":"10.1242","volume":"123","author":[{"given":"Cinzia","family":"Progida","sequence":"first","affiliation":[{"name":"Department of Biological and Environmental Sciences and Technologies (DiSTeBA), University of Salento, Via Provinciale Monteroni, 73100 Lecce, Italy"},{"name":"Centre for Immune Regulation, Department of Molecular Biosciences, University of Oslo, 0316 Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Cogli","sequence":"additional","affiliation":[{"name":"Department of Biological and Environmental Sciences and Technologies (DiSTeBA), University of Salento, Via Provinciale Monteroni, 73100 Lecce, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Piro","sequence":"additional","affiliation":[{"name":"Department of Biological and Environmental Sciences and Technologies (DiSTeBA), University of Salento, Via Provinciale Monteroni, 73100 Lecce, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azzurra","family":"De Luca","sequence":"additional","affiliation":[{"name":"Department of Biological and Environmental Sciences and Technologies (DiSTeBA), University of Salento, Via Provinciale Monteroni, 73100 Lecce, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oddmund","family":"Bakke","sequence":"additional","affiliation":[{"name":"Centre for Immune Regulation, Department of Molecular Biosciences, University of Oslo, 0316 Oslo, Norway"},{"name":"The Gade Institute, University of Bergen, 5021 Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Bucci","sequence":"additional","affiliation":[{"name":"Department of Biological and Environmental Sciences and Technologies (DiSTeBA), University of Salento, Via Provinciale Monteroni, 73100 Lecce, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042521313907300_R1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0167-4889(96)00146-2","article-title":"TGN38 and its orthologues: roles in post-TGN vesicle formation and maintenance of TGN morphology","volume":"1355","author":"Banting","year":"1997","journal-title":"Biochim. 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