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Cell Biol."},{"key":"2021042521401834300_R81","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1038\/40187","article-title":"Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension","volume":"389","author":"Uehata","year":"1997","journal-title":"Nature"},{"key":"2021042521401834300_R82","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/ncb2044","article-title":"Electron tomography reveals unbranched networks of actin filaments in lamellipodia","volume":"12","author":"Urban","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"2021042521401834300_R83","doi-asserted-by":"crossref","first-page":"22281","DOI":"10.1074\/jbc.271.37.22281","article-title":"Activation of Na+-H+ exchange is necessary for RhoA-induced stress fiber formation","volume":"271","author":"Vexler","year":"1996","journal-title":"J. Biol. Chem."},{"key":"2021042521401834300_R84","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1083\/jcb.200612043","article-title":"Regulation of protrusion, adhesion dynamics, and polarity by myosins IIA and IIB in migrating cells","volume":"176","author":"Vicente-Manzanares","year":"2007","journal-title":"J. Cell Biol."},{"key":"2021042521401834300_R85","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/nrm2786","article-title":"Non-muscle myosin II takes centre stage in cell adhesion and migration","volume":"10","author":"Vicente-Manzanares","year":"2009","journal-title":"Nat. Rev. Mol. 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Chem."},{"key":"2021042521401834300_R92","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1042\/BJ20041638","article-title":"PAK and other Rho-associated kinases-effectors with surprisingly diverse mechanisms of regulation","volume":"386","author":"Zhao","year":"2005","journal-title":"Biochem. 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