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Experiments with Saccharomyces cerevisiae as a heterologous expression system revealed that sucrose is a transported substrate. Because the knockout of SLC45A2, a highly similar protein belonging to the mammalian solute carrier family 45 (SLC45) causes oculocutaneous albinism and because the vesicular structures in which SCRT is located appear to contain melanin, we propose that these organelles are melanosome-like structures and that the transporter is necessary for balancing the osmotic equilibrium during the polymerization process of melanin by the import of a compatible osmolyte. In the hindgut epithelial cells, sucrose might also serve as a compatible osmolyte, but we cannot exclude the possibility that transport of this disaccharide also serves nutritional adequacy.<\/jats:p>","DOI":"10.1242\/jcs.082024","type":"journal-article","created":{"date-parts":[[2011,5,17]],"date-time":"2011-05-17T21:56:50Z","timestamp":1305669410000},"page":"1984-1991","source":"Crossref","is-referenced-by-count":62,"title":["Identification of an animal sucrose transporter"],"prefix":"10.1242","volume":"124","author":[{"given":"Heiko","family":"Meyer","sequence":"first","affiliation":[{"name":"Department of Biology and Chemistry, University of Osnabr\u00fcck, 49069 Osnabr\u00fcck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga","family":"Vitavska","sequence":"additional","affiliation":[{"name":"Department of Biology and Chemistry, University of Osnabr\u00fcck, 49069 Osnabr\u00fcck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helmut","family":"Wieczorek","sequence":"additional","affiliation":[{"name":"Department of Biology and Chemistry, University of Osnabr\u00fcck, 49069 Osnabr\u00fcck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","reference":[{"key":"2021042521283932000_R1","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1093\/bioinformatics\/bti263","article-title":"ProtTest: selection of best-fit models of protein evolution","volume":"21","author":"Abascal","year":"2005","journal-title":"Bioinformatics"},{"key":"2021042521283932000_R2","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1006\/excr.2001.5251","article-title":"Melanosomal pH controls rate of melanogenesis, eumelanin\/phaeomelanin ratio and melanosome maturation in melanocytes and melanoma cells","volume":"268","author":"Ancans","year":"2001","journal-title":"Exp. 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