{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:03:21Z","timestamp":1792170201160,"version":"4.4.0"},"reference-count":37,"publisher":"The Company of Biologists","issue":"21","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,11,1]]},"abstract":"<jats:p>Accumulation of adipocytes and collagen type-I-producing cells (fibrosis) is observed in muscular dystrophies. The origin of these cells had been largely unknown, but recently we identified mesenchymal progenitors positive for platelet-derived growth factor receptor alpha (PDGFR\u03b1) as the origin of adipocytes in skeletal muscle. However, the origin of muscle fibrosis remains largely unknown. In this study, clonal analyses show that PDGFR\u03b1+ cells also differentiate into collagen type-I-producing cells. In fact, PDGFR\u03b1+ cells accumulated in fibrotic areas of the diaphragm in the mdx mouse, a model of Duchenne muscular dystrophy. Furthermore, mRNA of fibrosis markers was expressed exclusively in the PDGFR\u03b1+ cell fraction in the mdx diaphragm. Importantly, TGF-\u03b2 isoforms, known as potent profibrotic cytokines, induced expression of markers of fibrosis in PDGFR\u03b1+ cells but not in myogenic cells. Transplantation studies revealed that fibrogenic PDGFR\u03b1+ cells mainly derived from pre-existing PDGFR\u03b1+ cells and that the contribution of PDGFR\u03b1\u2212 cells and circulating cells was limited. These results indicate that mesenchymal progenitors are the main origin of not only fat accumulation but also fibrosis in skeletal muscle.<\/jats:p>","DOI":"10.1242\/jcs.086629","type":"journal-article","created":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T23:36:58Z","timestamp":1320190618000},"page":"3654-3664","source":"Crossref","is-referenced-by-count":657,"title":["Fibrosis and adipogenesis originate from a common mesenchymal progenitor in skeletal muscle"],"prefix":"10.1242","volume":"124","author":[{"given":"Akiyoshi","family":"Uezumi","sequence":"first","affiliation":[{"name":"Division for Therapies Against Intractable Diseases, Institute for Comprehensive Medical Science, Fujita Health University, Kutsukake-cho, Toyoake, Aichi 470-1192, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahito","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Immunology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 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