{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T09:47:29Z","timestamp":1791020849150,"version":"4.1.0"},"reference-count":36,"publisher":"The Company of Biologists","issue":"4","license":[{"start":{"date-parts":[[2012,8,15]],"date-time":"2012-08-15T00:00:00Z","timestamp":1344988800000},"content-version":"vor","delay-in-days":182,"URL":"http:\/\/www.biologists.com\/user-licence-1-1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,2,15]]},"abstract":"<jats:p>Wnt\u2013\u03b2-catenin signaling regulates cell fate during organ development and postnatal tissue maintenance, but its contribution to specification of distinct lung epithelial lineages is still unclear. To address this question, we used a Cre recombinase (Cre)-LoxP approach to activate canonical Wnt signaling ectopically in developing lung endoderm. We found that persistent activation of canonical Wnt signaling within distal lung endoderm was permissive for normal development of alveolar epithelium, yet led to the loss of developing bronchiolar epithelium and ectasis of distal conducting airways. Activation of canonical Wnt led to ectopic expression of a lymphoid-enhancing factor and a T-cell factor (LEF and TCF, respectively) and absence of SRY (sex-determining region Y)-box 2 (SOX2) and tumor protein p63 (p63) expression in proximal derivatives. Conditional loss of SOX2 in airways phenocopied epithelial differentiation defects observed with ectopic activation of canonical Wnt. Our data suggest that Wnt negatively regulates a SOX2-dependent signaling program required for developmental progression of the bronchiolar lineage.<\/jats:p>","DOI":"10.1242\/jcs.092734","type":"journal-article","created":{"date-parts":[[2012,3,16]],"date-time":"2012-03-16T01:12:39Z","timestamp":1331860359000},"page":"932-942","source":"Crossref","is-referenced-by-count":92,"title":["\u03b2-Catenin\u2013SOX2 signaling regulates the fate of developing airway epithelium"],"prefix":"10.1242","volume":"125","author":[{"given":"Shuichi","family":"Hashimoto","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Duke University Medical Center, 106 Research Drive, 2075 MSRBII, DUMC Box 103000, Durham, NC, 27710, USA"},{"name":"Department of Cell Biology, Duke University Medical Center, Box 3709, Durham, NC, 27710, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaiyong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Duke University Medical Center, 106 Research Drive, 2075 MSRBII, DUMC Box 103000, Durham, NC, 27710, USA"},{"name":"Department of Cell Biology, Duke University Medical Center, Box 3709, Durham, NC, 27710, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianwen","family":"Que","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Duke University Medical Center, Box 3709, Durham, NC, 27710, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian L.","family":"Brockway","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Duke University Medical Center, 106 Research Drive, 2075 MSRBII, DUMC Box 103000, Durham, NC, 27710, USA"},{"name":"Department of Cell Biology, Duke University Medical Center, Box 3709, Durham, NC, 27710, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey A.","family":"Drake","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Duke University Medical Center, 106 Research Drive, 2075 MSRBII, DUMC Box 103000, Durham, NC, 27710, USA"},{"name":"Department of Cell Biology, Duke University Medical Center, Box 3709, Durham, NC, 27710, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua C.","family":"Snyder","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Duke University Medical Center, 106 Research Drive, 2075 MSRBII, DUMC Box 103000, Durham, NC, 27710, USA"},{"name":"Department of Cell Biology, Duke University Medical Center, Box 3709, Durham, NC, 27710, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott H.","family":"Randell","sequence":"additional","affiliation":[{"name":"Departments of Cell and Molecular Physiology and Medicine, The University of North Carolina at Chapel Hill, 111 Mason Farm Road, 5200 Medical Biomolecular Research Building, CB 7545 Chapel Hill, NC, 27599-7545, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry R.","family":"Stripp","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Duke University Medical Center, 106 Research Drive, 2075 MSRBII, DUMC Box 103000, Durham, NC, 27710, USA"},{"name":"Department of Cell Biology, Duke University Medical Center, Box 3709, Durham, NC, 27710, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042522255126400_R1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1083\/jcb.200311021","article-title":"SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes","volume":"166","author":"Blache","year":"2004","journal-title":"J. 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