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As, such, this system was used to explore the mechanism by which these molecules act to produce coordinated cell movement during development. In the present study, GABA and SDF-1 are shown to exert opposite effects on the speed of cell movement by activating depolarizing or hyperpolarizing signaling pathways, GABA via changes in chloride and SDF-1 via changes in potassium. GABA and SDF-1 were also found to act synergistically to promote linear rather than random movement. The simultaneous activation of these signaling pathways therefore results in tight control of cellular speed and improved directionality along the migratory pathway of GnRH neurons.<\/jats:p>","DOI":"10.1242\/jcs.101675","type":"journal-article","created":{"date-parts":[[2012,9,15]],"date-time":"2012-09-15T01:11:02Z","timestamp":1347671462000},"source":"Crossref","is-referenced-by-count":38,"title":["SDF and GABA interact to regulate axophilic migration of GnRH neurons"],"prefix":"10.1242","author":[{"given":"Filippo","family":"Casoni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. 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