{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T20:50:34Z","timestamp":1760907034929},"reference-count":39,"publisher":"The Company of Biologists","issue":"4","license":[{"start":{"date-parts":[[1992,12,1]],"date-time":"1992-12-01T00:00:00Z","timestamp":723168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1992,12,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Pericentric inversion of the secondary constriction region (qh) of human chromosome 9 is a frequent occurrence. This structural alteration is regarded as a normal familial variant, termed heteromorphism, and is inherited in a Mendelian fashion without any apparent phenotypic consequences. We characterized the qh region of chromosome 9 from five individuals using a series of molecular cytogenetic techniques. Four out of the five individuals have an additional area composed of alphoid DNA sequences on the inverted chromosome 9 while one case was found to have an apparently intact alphoid DNA sequence. Although the direct function(s) of alphoid DNA sequences remain unclear, the centromeric breakage involving these sequences in inverted chromsome 9 raises a series of questions pertaining to the monocentric, dicentric and pseudodicentric nature of pericentric inversions. Nevertheless, these findings have prompted us to suggest that the structural organization of alphoid DNA sequences of the centromeric region of chromosome 9 are apparently \u201cbreakage prone\u201d and may be associated with a higher incidence of pericentric inversions. Furthermore, the hierarchical organization of various satellite DNA families (\u03b1-satellite, \u03b2-satellite and satellite III) within the primary and secondary constriction regions of chromosomes 9 are elucidated here.<\/jats:p>","DOI":"10.1242\/jcs.103.4.919","type":"journal-article","created":{"date-parts":[[2021,4,25]],"date-time":"2021-04-25T15:45:11Z","timestamp":1619365511000},"page":"919-923","source":"Crossref","is-referenced-by-count":28,"title":["Molecular characterization of the secondary constriction region (qh) of human chromosome 9 with pericentric inversion"],"prefix":"10.1242","volume":"103","author":[{"given":"Sunny","family":"Luke","sequence":"first","affiliation":[{"name":"Division of Genetics, The Long Island College Hospital -SUNY Health Science Center, Brooklyn, New York 11201, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ram S.","family":"Verma","sequence":"additional","affiliation":[{"name":"Division of Genetics, The Long Island College Hospital -SUNY Health Science Center, Brooklyn, New York 11201, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A. Contethomas","family":"Mathews","sequence":"additional","affiliation":[{"name":"Division of Genetics, The Long Island College Hospital -SUNY Health Science Center, Brooklyn, New York 11201, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[1992,12,1]]},"reference":[{"key":"2024071019161933600_JOCES_103_4_919C1","first-page":"301","article-title":"Identification of chromosome specific satellite DNA using non-isotopic in situ hybridization","volume-title":"In Advances in Genome Biology","author":"Adinolfi","year":"1992"},{"key":"2024071019161933600_JOCES_103_4_919C2","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/BF00284712","article-title":"p82H identifies sequences at every human centromere","volume":"77","author":"Aleixandre","year":"1987","journal-title":"Hum. 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