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Its overexpression results in excess centriole formation. siRNA-mediated depletion of STIL leads to loss of centrioles and abrogates PLK4-induced centriole overduplication. Additionally, we show that STIL is necessary for SAS6 recruitment to centrioles, suggesting that it is essential for daughter centriole formation, interacts with the centromere protein CPAP and rapidly shuttles between the cytoplasm and centrioles. Consistent with the requirement of centrioles for cilia formation, Stil\u2013\/\u2013 mouse embryonic fibroblasts lack primary cilia \u2013 a phenotype that can be reverted by restoration of STIL expression. These findings demonstrate that STIL is an essential component of the centriole replication machinery in mammalian cells.<\/jats:p>","DOI":"10.1242\/jcs.104109","type":"journal-article","created":{"date-parts":[[2012,2,21]],"date-time":"2012-02-21T01:55:17Z","timestamp":1329789317000},"page":"1353-1362","source":"Crossref","is-referenced-by-count":183,"title":["STIL is required for centriole duplication in human cells"],"prefix":"10.1242","volume":"125","author":[{"given":"Julia","family":"Vulprecht","sequence":"first","affiliation":[{"name":"Clinical Cooperation Unit Molecular Hematology\/Oncology, German Cancer Research Center (DKFZ) and Dept. of Internal Medicine V, University of Heidelberg, 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahuvit","family":"David","sequence":"additional","affiliation":[{"name":"Sheba Cancer Research Center and the Edmond and Lily Safra Children\u2019s Hospital, Sheba Medical Center, Tel-Hashomer 52621, Ramat Gan, Israel"},{"name":"Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv 69978, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Tibelius","sequence":"additional","affiliation":[{"name":"Clinical Cooperation Unit Molecular Hematology\/Oncology, German Cancer Research Center (DKFZ) and Dept. of Internal Medicine V, University of Heidelberg, 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asher","family":"Castiel","sequence":"additional","affiliation":[{"name":"Sheba Cancer Research Center and the Edmond and Lily Safra Children\u2019s Hospital, Sheba Medical Center, Tel-Hashomer 52621, Ramat Gan, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gleb","family":"Konotop","sequence":"additional","affiliation":[{"name":"Max-Eder-Junior Research Group Experimental Therapies for Hematologic Malignancies, German Cancer Research Center (DKFZ) and Dept. of Internal Medicine V, University of Heidelberg, 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengying","family":"Liu","sequence":"additional","affiliation":[{"name":"Clinical Cooperation Unit Molecular Hematology\/Oncology, German Cancer Research Center (DKFZ) and Dept. of Internal Medicine V, University of Heidelberg, 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Bestvater","sequence":"additional","affiliation":[{"name":"Core Facility Light Microscopy, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc S.","family":"Raab","sequence":"additional","affiliation":[{"name":"Max-Eder-Junior Research Group Experimental Therapies for Hematologic Malignancies, German Cancer Research Center (DKFZ) and Dept. of Internal Medicine V, University of Heidelberg, 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanswalter","family":"Zentgraf","sequence":"additional","affiliation":[{"name":"Dept. of Tumor Virology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shai","family":"Izraeli","sequence":"additional","affiliation":[{"name":"Sheba Cancer Research Center and the Edmond and Lily Safra Children\u2019s Hospital, Sheba Medical Center, Tel-Hashomer 52621, Ramat Gan, Israel"},{"name":"Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv 69978, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alwin","family":"Kr\u00e4mer","sequence":"additional","affiliation":[{"name":"Clinical Cooperation Unit Molecular Hematology\/Oncology, German Cancer Research Center (DKFZ) and Dept. of Internal Medicine V, University of Heidelberg, 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042522302258100_R1","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1136\/jmg.2009.076646","article-title":"Novel CENPJ mutation causes Seckel syndrome","volume":"47","author":"Al-Dosari","year":"2010","journal-title":"J. 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