{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:59:01Z","timestamp":1791302341184,"version":"4.1.0"},"reference-count":40,"publisher":"The Company of Biologists","issue":"1","license":[{"start":{"date-parts":[[1994,1,1]],"date-time":"1994-01-01T00:00:00Z","timestamp":757382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1994,1,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>The connectin gene of Drosophila has been identified as a candidate direct target of homeotic gene control and has also been implicated in the formation of specific neuro-muscular connections. The gene product, connectin, is a member of the leucine-rich repeat protein family and we show that it is attached to the cell surface via a glycosyl-phosphatidylinositol linkage and that it can mediate homotypic cell-cell adhesion in vitro. The expression of connectin protein during Drosophila embryogenesis provides support for a role in adhesion in vivo. In the central nervous system, it is initially expressed on longitu-dinal glia and on a few identified neurons. These cells extend processes and connect up to form a continuous scaffold of connectin-expressing cells, presaging the devel-opment of axonal pathways. Later, connectin is expressed on specific axons as they track along the connectin scaffold. Glial expression then declines and connectin appears on axons that fasciculate with pre-existing connectin-positive bundles. Thus scaffold formation, axon pathfinding and fasciculation involve specific contacts between connectin-positive cells. The timing and pattern of connectin expression suggest that it may play an important role in mediating specific interactions through homotypic cell adhesion.<\/jats:p>","DOI":"10.1242\/jcs.107.1.321","type":"journal-article","created":{"date-parts":[[2021,4,25]],"date-time":"2021-04-25T15:50:46Z","timestamp":1619365846000},"page":"321-328","source":"Crossref","is-referenced-by-count":54,"title":["The cell adhesion molecule, connectin, and the development of the <i>Drosophila<\/i> neuromuscular system"],"prefix":"10.1242","volume":"107","author":[{"given":"Lisa A.","family":"Meadows","sequence":"first","affiliation":[{"name":"University of Cambridge, Downing Street, Cambridge CB2 3DY 1 Department of Anatomy , , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Gell","sequence":"additional","affiliation":[{"name":"University of Cambridge, Downing Street 2 Department of Zoology , , Cambridge CB2 3EJ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kendal","family":"Broadie","sequence":"additional","affiliation":[{"name":"University of Cambridge, Downing Street 2 Department of Zoology , , Cambridge CB2 3EJ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex P.","family":"Gould","sequence":"additional","affiliation":[{"name":"University of Cambridge, Downing Street, Cambridge CB2 3DY 1 Department of Anatomy , , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A. H.","family":"White","sequence":"additional","affiliation":[{"name":"University of Cambridge, Downing Street, Cambridge CB2 3DY 1 Department of Anatomy , , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[1994,1,1]]},"reference":[{"key":"2024022702335627500_JOCES_107_1_321C1","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1242\/dev.110.3.791","article-title":"The embryonic development of larval muscles in Drosophila","volume":"110","author":"Bate","year":"1990","journal-title":"Development"},{"key":"2024022702335627500_JOCES_107_1_321C2","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1242\/dev.113.1.79","article-title":"Cells with persistent twist expression are the embryonic precursors of adult muscles in Drosophila","volume":"113","author":"Bate","year":"1991","journal-title":"Development"},{"key":"2024022702335627500_JOCES_107_1_321C3","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1083\/jcb.112.3.377","article-title":"The glycosyl phospatidylinositol anchor is critical for Ly-6A\/E-mediated T cell activation","volume":"112","author":"Bing","year":"1991","journal-title":"J. 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