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In cultured cells, we demonstrated cell cycle-dependent accumulation of WDR62 at the spindle pole during mitotic entry that persisted until metaphase-anaphase transition. Utilizing siRNA-depletion, we revealed WDR62 function in stabilizing the mitotic spindle specifically during metaphase. WDR62 loss resulted in spindle orientation defects, decreased the integrity of centrosomes displaced from the spindle pole and delayed mitotic progression. Additionally, we revealed JNK phosphorylation of WDR62 was required for maintaining metaphase spindle organization during mitosis. Our study provides the first functional characterization of WDR62 and has revealed requirements for JNK\/WDR62-signalling in mitotic spindle regulation that may be involved in coordinating neurogenesis.<\/jats:p>","DOI":"10.1242\/jcs.107326","type":"journal-article","created":{"date-parts":[[2012,8,17]],"date-time":"2012-08-17T00:26:31Z","timestamp":1345163191000},"source":"Crossref","is-referenced-by-count":62,"title":["WD40-repeat protein 62 is a JNK-phosphorylated spindle pole protein required for spindle maintenance and timely mitotic progression."],"prefix":"10.1242","author":[{"given":"Marie A.","family":"Bogoyevitch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne Y. 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