{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T06:31:18Z","timestamp":1779345078744,"version":"3.51.4"},"reference-count":63,"publisher":"The Company of Biologists","issue":"5","license":[{"start":{"date-parts":[[1995,5,1]],"date-time":"1995-05-01T00:00:00Z","timestamp":799286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1995,5,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Madin-Darby canine kidney and other epithelial cell lines (e.g. Caco-2, MCF-10A and MCF-7) develop intracellular vacuoles composed of apical membrane displaying microvilli (VACs) when impaired from forming normal cell-to-cell contacts. In a previous publication, we showed that VACs are rapidly exocytosed upon treatment with 8-Br-3\u2019,5\u2019-cyclic adenosine monophosphate (8-Br-cAMP), a membrane-permeable analog of cAMP, and that this exocytosis correlates with variations in the cellular cAMP concentration in response to the cell-cell contacts. In the present work, we tested the hypothesis that cAMP may be a positive modulator of the \u2018constitutive\u2019 exocytic pathway. To mimic conditions in cells with incomplete intercellular contacts, the intracellular levels of cAMP were decreased by means of two independent approaches: (i) pores were induced in the plasma membrane with the polypeptidic antibiotic subtilin, thus allowing small molecules (including cAMP) to permeate and move out of the cytoplasm; and (ii) adenylate cyclase and protein kinase A were blocked with specific inhibitors. In all cases, the intracellular levels of cAMP were measured and, in porated cells, equilibrated to simulate the corresponding physiological intracellular concentrations. The decrease in cAMP within the physiological range resulted in a decreased rate of transport of an apical marker of the constitutive pathway (influenza virus hemagglutinin) from the trans -Golgi network to the apical plasma membrane. Likewise, the delivery of a number of cellular apical proteins to the plasma membrane was retarded at low cAMP concentrations. The inhibitors of adenylate cyclase failed to block basolateral delivery of vesicular stomatitis virus G protein. This differential modulatory effect may represent a differentiation-dependent control of the insertion of apical membrane in epithelial cells.<\/jats:p>","DOI":"10.1242\/jcs.108.5.1931","type":"journal-article","created":{"date-parts":[[2021,4,24]],"date-time":"2021-04-24T02:36:36Z","timestamp":1619231796000},"page":"1931-1943","source":"Crossref","is-referenced-by-count":23,"title":["Cyclic AMP modulates the rate of \u2018constitutive\u2019 exocytosis of apical membrane proteins in Madin-Darby canine kidney cells"],"prefix":"10.1242","volume":"108","author":[{"given":"Mirtha","family":"Brignoni","sequence":"first","affiliation":[{"name":"1 Instituto de Investigaciones Bioqu\u00edmicas L.F. Leloir, Fundaci\u00f3n Campomar, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar P.","family":"Pignataro","sequence":"additional","affiliation":[{"name":"2 Instituto de Biolog\u00eda y Medicina Experimental, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo L.","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"1 Instituto de Investigaciones Bioqu\u00edmicas L.F. Leloir, Fundaci\u00f3n Campomar, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Alvarez","sequence":"additional","affiliation":[{"name":"1 Instituto de Investigaciones Bioqu\u00edmicas L.F. Leloir, Fundaci\u00f3n Campomar, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dora E.","family":"Vega-Salas","sequence":"additional","affiliation":[{"name":"University of Miami School of Medicine, Department of Cell Biology and Anatomy 4 , PO Box 016960, Miami, FL 33101, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrique","family":"Rodriguez-Boulan","sequence":"additional","affiliation":[{"name":"Cornell University Medical College, Department of Cell Biology and Anatomy 3 , New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro J. I.","family":"Salas","sequence":"additional","affiliation":[{"name":"University of Miami School of Medicine, Department of Cell Biology and Anatomy 4 , PO Box 016960, Miami, FL 33101, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[1995,5,1]]},"reference":[{"key":"2023122621433976000_JOCES_108_5_1931C1","first-page":"249","article-title":"Inhibition of cell growth in the G1 phase by adenosine 3\u2019, 5\u2019-cyclic monophosphate","volume":"60","author":"Abell","year":"1973","journal-title":"J. Cell Biol"},{"key":"2023122621433976000_JOCES_108_5_1931C2","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/0167-4889(87)90175-3","article-title":"The effect of calcium and cyclic AMP on amylase release in digitonin-permeabilized parotid gland cells","volume":"929","author":"Baldys-Waligorska","year":"1987","journal-title":"Biochim. Biophys. Acta"},{"key":"2023122621433976000_JOCES_108_5_1931C3","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1016\/0955-0674(93)90032-L","article-title":"Juxtacrine cell signaling molecules","volume":"5","author":"Bosenberg","year":"1993","journal-title":"Curr. Opin. Cell Biol"},{"key":"2023122621433976000_JOCES_108_5_1931C4","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1016\/0092-8674(88)90081-5","article-title":"Do GTPases direct membrane traffic in secretion?","volume":"53","author":"Bourne","year":"1988","journal-title":"Cell"},{"key":"2023122621433976000_JOCES_108_5_1931C5","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1006\/excr.1993.1072","article-title":"Exocytosis of the Vacuolar Apical Compartment (VAC) in Madin-Darby canine kidney epithelial cells: cAMP is involved as second messenger","volume":"205","author":"Brignoni","year":"1993","journal-title":"Exp. Cell Res"},{"key":"2023122621433976000_JOCES_108_5_1931C6","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1146\/annurev.cb.03.110187.001331","article-title":"Constitutive and regulated secretion of proteins","volume":"3","author":"Burgess","year":"1987","journal-title":"Annu. Rev. Cell Biol"},{"key":"2023122621433976000_JOCES_108_5_1931C7","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/BF01868808","article-title":"Cell-to-cell communication in monolayers of epithelioid cells (MDCK) as a function of the age of the monolayer","volume":"81","author":"Cereijido","year":"1984","journal-title":"J. Membr. Biol"},{"key":"2023122621433976000_JOCES_108_5_1931C8","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1146\/annurev.cb.09.110193.003043","article-title":"The role of GTP-binding proteins in the transport along the exocytic pathway","volume":"9","author":"Ferro-Novick","year":"1993","journal-title":"Annu. Rev. Cell Biol"},{"key":"2023122621433976000_JOCES_108_5_1931C9","first-page":"549","article-title":"Inhibition of cell growth in the G1 phase by adenosine 3\u2019, 5\u2019-cyclic monophosphate","volume":"59","author":"Froehlich","year":"1974","journal-title":"J. Cell Biol"},{"key":"2023122621433976000_JOCES_108_5_1931C10","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1242\/jcs.100.3.451","article-title":"Induction of vacuolar apical compartments in the Caco-2 intestinal epithelial cell line","volume":"100","author":"Gilbert","year":"1991","journal-title":"J. Cell Sci"},{"key":"2023122621433976000_JOCES_108_5_1931C11","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/BF01870778","article-title":"Tight-junction formation in cultured epithelial cells (MDCK)","volume":"86","author":"Gonzalez-Mariscal","year":"1985","journal-title":"J. Membr. Biol"},{"key":"2023122621433976000_JOCES_108_5_1931C12","doi-asserted-by":"publisher","first-page":"2100","DOI":"10.1073\/pnas.83.7.2100","article-title":"Secretion of endogenous and exogenous proteins from polarized MDCK cell monolayers","volume":"83","author":"Gottlieb","year":"1986","journal-title":"Proc. Nat. Acad. Sci. USA"},{"key":"2023122621433976000_JOCES_108_5_1931C13","doi-asserted-by":"publisher","first-page":"2893","DOI":"10.1083\/jcb.111.6.2893","article-title":"Transport of influenza HA from the trans-Golgi network to the apical surface of MDCK cells permeabilized in their basolateral plasma membranes: energy dependence and involvement of GTP-binding proteins","volume":"111","author":"Gravota","year":"1990","journal-title":"J. Cell Biol"},{"key":"2023122621433976000_JOCES_108_5_1931C14","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1083\/jcb.101.3.949","article-title":"Exit of newly synthesized membrane proteins from the trans-cisterna of the Golgi complex to the plasma membrane","volume":"101","author":"Griffiths","year":"1985","journal-title":"J. Cell Biol"},{"key":"2023122621433976000_JOCES_108_5_1931C15","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1083\/jcb.126.3.677","article-title":"Gs alpha stimulates transcytosis and apical secretion in MDCK cells through cAMP and protein kinase A","volume":"126","author":"Hansen","year":"1994","journal-title":"J. Cell Biol"},{"issue":"2","key":"2023122621433976000_JOCES_108_5_1931C16","first-page":"79","article-title":"The influence of tissue microenvironment (stroma and extracellular matrix) on the development and function of mammary epithelium","volume":"2","author":"Howlett","year":"1993","journal-title":"Epithel. Cell Biol"},{"key":"2023122621433976000_JOCES_108_5_1931C17","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1210\/endo.132.2.7678794","article-title":"Basal transcriptional activity and cyclic adenosine 3\u2019, 5\u2019-monophosphate responsiveness of the human cytochrome P450scc promoter treansfected into MA-10 Leydig cells","volume":"132","author":"Hum","year":"1993","journal-title":"Endocrinology"},{"key":"2023122621433976000_JOCES_108_5_1931C18","doi-asserted-by":"publisher","first-page":"186194","DOI":"10.1002\/jcp.1041400122","article-title":"Reduction of adenine nucleotide content of clone 4 MDCK cells: effects on multiplication, protein synthesis and morphology","volume":"140","author":"Ladino","year":"1989","journal-title":"J. Cell. Physiol"},{"key":"2023122621433976000_JOCES_108_5_1931C19","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1083\/jcb.117.6.1197","article-title":"Mechanism of cholera toxin action on a polarized human intestinal epithelial cell line: role of vesicular traffic","volume":"117","author":"Lencer","year":"1992","journal-title":"J. Cell Biol"},{"key":"2023122621433976000_JOCES_108_5_1931C20","doi-asserted-by":"publisher","first-page":"5482","DOI":"10.1073\/pnas.74.12.5482","article-title":"Two distinct adenosine-sensitive sites on adenylate cyclase","volume":"74","author":"Londos","year":"1977","journal-title":"Proc. Nat. Acad. Sci. USA"},{"key":"2023122621433976000_JOCES_108_5_1931C21","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1042\/bj2710635","article-title":"Cyclic AMP stimulates luteinizing-hormone (lutropin) exocytosis in permeabilized sheep anterior-pituitary cells","volume":"271","author":"Macrae","year":"1990","journal-title":"Biochem. J"},{"key":"2023122621433976000_JOCES_108_5_1931C22","doi-asserted-by":"publisher","first-page":"6007","DOI":"10.1073\/pnas.86.15.6007","article-title":"Renal epithelial cyst formation and enlargement in vitro: dependence on cAMP","volume":"86","author":"Mangoo-Karim","year":"1989","journal-title":"Proc. Nat. Acad. Sci USA"},{"key":"2023122621433976000_JOCES_108_5_1931C23","first-page":"1874","article-title":"Augmentation of postconfluence growth arrest of 10T1\/2 fibroblasts by endogenous cyclic adenosine 3\u2019,5\u2019-monophosphate","volume":"48","author":"Matsukawa","year":"1988","journal-title":"Cancer Res"},{"key":"2023122621433976000_JOCES_108_5_1931C24","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1111\/j.1432-1033.1991.tb15819.x","article-title":"Treatment of intact striatal neurones with cholera toxin or 8-bromoadenosine 3\u2019,5\u2019-(cyclic)phosphate decreases the ability of pertussis toxin to ADP-ribosylate the alpha subunits of inhibitory and other guanine-nucleotide-binding regulatory proteins, Gi and Go. Evidence for two distinct mechanisms","volume":"196","author":"Maus","year":"1991","journal-title":"Eur. J. Biochem"},{"key":"2023122621433976000_JOCES_108_5_1931C25","doi-asserted-by":"publisher","first-page":"313","DOI":"10.3109\/10799899309073663","article-title":"D2-dopaminergic agonist quipirole and 8-bromo-cAMP have opposite effects on Go alpha GTP-binding protein mRNA without changing D2 dopamine receptor mRNA levels in striatal neurones in primary culture","volume":"13","author":"Maus","year":"1993","journal-title":"J. Recept. Res"},{"key":"2023122621433976000_JOCES_108_5_1931C26","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1016\/0014-4827(89)90102-X","article-title":"Regulation by intracellular Ca2+ and cyclic AMP of the growth factor-induced ruffling membrane formation and stimulation of fluid-phase endocytosis and exocytosis","volume":"181","author":"Miyata","year":"1989","journal-title":"Exp. Cell Res"},{"key":"2023122621433976000_JOCES_108_5_1931C27","first-page":"561","article-title":"Transcriptional regulation of inhibin beta B messenger ribonucleic acid levels in TM.4 or primary rat Sertoli cells by 8-bromo-cyclic adenosine monophosphate","volume":"7","author":"Najmabadi","year":"1993","journal-title":"Mol. Endocrinol"},{"key":"2023122621433976000_JOCES_108_5_1931C28","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1038\/ki.1992.184","article-title":"In vitro formation and expansion of cysts derived from human renal cortex epithelial cells","volume":"41","author":"Neufeld","year":"1992","journal-title":"Kidney Int"},{"key":"2023122621433976000_JOCES_108_5_1931C29","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1073\/pnas.71.3.694","article-title":"Intracellular cyclic AMP concentration responds specifically to growth regulation by serum","volume":"71","author":"Oey","year":"1974","journal-title":"Proc. Nat. Acad. Sci. USA"},{"key":"2023122621433976000_JOCES_108_5_1931C30","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1016\/0092-8674(87)90590-3","article-title":"The trans-most cisternae of the Golgi complex: a compartment for sorting of secretory and plasma membrane proteins","volume":"51","author":"Orci","year":"1987","journal-title":"Cell"},{"key":"2023122621433976000_JOCES_108_5_1931C31","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1016\/0092-8674(93)90545-2","article-title":"Stepwise assembly of functionally active transport vesicles","volume":"75","author":"Ostermann","year":"1993","journal-title":"Cell"},{"key":"2023122621433976000_JOCES_108_5_1931C32","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1016\/S0006-291X(71)80212-7","article-title":"Cyclic AMP levels in fibroblasts: relationship to growth rate and contact inhibition of growth","volume":"44","author":"Otten","year":"1971","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"2023122621433976000_JOCES_108_5_1931C33","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1210\/mend-4-5-758","article-title":"Studies with insulin and insulin-like growth factor I show that the increased labelling of phosphatidylinositol-3,4-biphosphate is not sufficient to elicit the diverse actions of epidermal growth factor on MA-10 Leydig tumor cells","volume":"4","author":"Pignataro","year":"1990","journal-title":"Mol. Endocrinol"},{"key":"2023122621433976000_JOCES_108_5_1931C34","doi-asserted-by":"publisher","first-page":"2745","DOI":"10.1210\/endo.130.5.1374014","article-title":"Cyclic adenosine 3\u2019,5\u2019monophosphate negatively regulates clusterin gene expression in Leydig tumor cell lines","volume":"130","author":"Pignataro","year":"1992","journal-title":"Endocrinology"},{"key":"2023122621433976000_JOCES_108_5_1931C35","doi-asserted-by":"publisher","first-page":"456458","DOI":"10.1038\/362456a0","article-title":"Regulation of apical transport in epithelial cells by a Gs class of heterotrimeric G protein","volume":"362","author":"Pimplikar","year":"1993","journal-title":"Nature"},{"key":"2023122621433976000_JOCES_108_5_1931C36","doi-asserted-by":"publisher","first-page":"19054","DOI":"10.1016\/S0021-9258(17)32273-1","article-title":"Activators of protein kinase A stimulate apical but not basolateral transport in epithelial MDCK cells","volume":"269","author":"Pimplikar","year":"1994","journal-title":"J. Biol. Chem"},{"key":"2023122621433976000_JOCES_108_5_1931C37","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1111\/j.1768-322X.1986.tb00446.x","article-title":"The intracellular lumen: origin, role and implications of a cytoplasmic neostructure","volume":"56","author":"Remy","year":"1986","journal-title":"Biol. Cell"},{"key":"2023122621433976000_JOCES_108_5_1931C38","first-page":"119","article-title":"Membrane biogenesis, enveloped RNA viruses, and epithelial polarity","volume":"1","author":"Rodr\u00edguez-Boulan","year":"1983","journal-title":"Mod. Cell Biol"},{"key":"2023122621433976000_JOCES_108_5_1931C39","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1016\/0076-6879(83)98176-4","article-title":"Polarized budding of viruses from epithelial cells","volume":"98","author":"Rodr\u00edguez-Boulan","year":"1983","journal-title":"Meth. Enzymol"},{"key":"2023122621433976000_JOCES_108_5_1931C40","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1083\/jcb.98.1.308","article-title":"Intracellular transport of Influenza virus hemagglutinin to the apical surface of Madin-Darby Canine Kidney Cells","volume":"98","author":"Rodr\u00edguez-Boulan","year":"1984","journal-title":"J. Cell Biol"},{"key":"2023122621433976000_JOCES_108_5_1931C41","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1126\/science.2672330","article-title":"Morphogenesis of the polarized epithelial cell phenotype","volume":"245","author":"Rodr\u00edguez-Boulan","year":"1989","journal-title":"Science"},{"key":"2023122621433976000_JOCES_108_5_1931C42","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/S0091-679X(08)61166-8","article-title":"Methods to estimate the polarized distribution of surface antigens in cultured epithelial cells","volume":"32","author":"Rodr\u00edguez-Boulan","year":"1989","journal-title":"Meth. Cell Biol"},{"key":"2023122621433976000_JOCES_108_5_1931C43","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1146\/annurev.cb.08.110192.002143","article-title":"Polarity of epithelial and neuronal cells","volume":"8","author":"Rodr\u00edguez-Boulan","year":"1992","journal-title":"Annu. Rev. Cell Biol"},{"key":"2023122621433976000_JOCES_108_5_1931C44","first-page":"377","article-title":"Production, purification and chemical properties of an antistaphylococcal agent produced by Staphylococcus epidermidis","volume":"127","author":"Sahl","year":"1981","journal-title":"J. Gen. Microbiol"},{"key":"2023122621433976000_JOCES_108_5_1931C45","doi-asserted-by":"publisher","first-page":"1853","DOI":"10.1083\/jcb.102.5.1853","article-title":"Microtubules and actin microfilaments are not critically involved in the biogenesis of epithelial cell surface polarity","volume":"102","author":"Salas","year":"1986","journal-title":"J. Cell Biol"},{"key":"2023122621433976000_JOCES_108_5_1931C46","doi-asserted-by":"publisher","first-page":"2363","DOI":"10.1083\/jcb.107.6.2363","article-title":"Selective anchoring in the specific plasma membrane domain: a role in epithelial cell polarity","volume":"107","author":"Salas","year":"1988","journal-title":"J. Cell Biol"},{"key":"2023122621433976000_JOCES_108_5_1931C47","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1083\/jcb.117.1.57","article-title":"Intracellular cyclic AMP, not calcium, determines the direction of vesicle movement in melanophores: direct measurement by fluorescence ratio imaging","volume":"117","author":"Sammak","year":"1992","journal-title":"J. Cell Biol"},{"key":"2023122621433976000_JOCES_108_5_1931C48","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1007\/BF01871942","article-title":"Integral and peripheral protein composition of the apical and basolateral membrane domains in MDCK cells","volume":"107","author":"Sargiacomo","year":"1989","journal-title":"J. Membr. Biol"},{"key":"2023122621433976000_JOCES_108_5_1931C49","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1006\/scel.1993.1020","article-title":"Modulation of epithelial morphogenesis and cell fate by cell-to-cell signals and regulated cell adhesion","volume":"4","author":"Schmidt","year":"1993","journal-title":"Semin. Cell Biol"},{"key":"2023122621433976000_JOCES_108_5_1931C50","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1111\/j.1432-1033.1989.tb14815.x","article-title":"The peptide antibiotic subtilin acts by formation of voltage-dependent multi-state pores in bacterial and artificial membranes","volume":"182","author":"Schuller","year":"1989","journal-title":"Eur. J. Biochem"},{"key":"2023122621433976000_JOCES_108_5_1931C51","doi-asserted-by":"publisher","first-page":"1847","DOI":"10.1152\/jn.1991.66.6.1847","article-title":"Serotonin inhibits the peptide FMRFamide response through a cyclic AMP-independent pathway in Aplysia","volume":"66","author":"Shi","year":"1991","journal-title":"J. Neurophysiol"},{"key":"2023122621433976000_JOCES_108_5_1931C52","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1146\/annurev.cb.01.110185.001331","article-title":"Cell surface polarity in epithelia","volume":"1","author":"Simons","year":"1985","journal-title":"Annu. Rev. Cell Biol"},{"key":"2023122621433976000_JOCES_108_5_1931C53","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/0092-8674(90)90357-K","article-title":"Polarized sorting in epithelia","volume":"62","author":"Simons","year":"1990","journal-title":"Cell"},{"key":"2023122621433976000_JOCES_108_5_1931C54","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1093\/oxfordjournals.jbchem.a123171","article-title":"Evidence for the involvement of cAMP-dependent protein kinase in the exocytosis of amylase from parotid acinar cells","volume":"108","author":"Takuma","year":"1990","journal-title":"J. Biochem"},{"key":"2023122621433976000_JOCES_108_5_1931C55","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1146\/annurev.cb.08.110192.002241","article-title":"Structural framework for the protein kinase family","volume":"8","author":"Taylor","year":"1992","journal-title":"Annu. Rev. Cell Biol"},{"key":"2023122621433976000_JOCES_108_5_1931C56","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/0012-1606(87)90112-6","article-title":"Morphogenetic restructuring and formation of basement membranes by Sertoli cells and testis peritubular cells in coculture: inhibition of the morphogenetic cascade by cyclic AMP derivatives and by blocking direct cell contact","volume":"120","author":"Tung","year":"1987","journal-title":"Dev. Biol"},{"key":"2023122621433976000_JOCES_108_5_1931C57","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1083\/jcb.104.5.1249","article-title":"Modulation of the expression of an apical plasma membrane protein of Madin-Darby canine kidney epithelial cells: cell-cell interactions control the appearance of a novel intracellular storage compartment","volume":"104","author":"Vega-Salas","year":"1987","journal-title":"J. Cell Biol"},{"key":"2023122621433976000_JOCES_108_5_1931C58","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1083\/jcb.104.4.905","article-title":"Formation of the apical pole of epithelial (Madin-Darby canine kidney) cells: polarity of an apical protein is independent of tight-junctions while segregation of a basolateral marker requires cell-cell interactions","volume":"104","author":"Vega-Salas","year":"1987","journal-title":"J. Cell Biol"},{"key":"2023122621433976000_JOCES_108_5_1931C59","doi-asserted-by":"publisher","first-page":"1717","DOI":"10.1083\/jcb.107.5.1717","article-title":"Exocytosis of Vacuolar Apical Compartment (VAC): a cell-cell contact controlled mechanism for the establishment of the apical plasma membrane domain in epithelial cells","volume":"107","author":"Vega-Salas","year":"1988","journal-title":"J. Cell Biol"},{"key":"2023122621433976000_JOCES_108_5_1931C60","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1111\/j.1432-0436.1993.tb01596.x","article-title":"Vacuolar Apical Compartment in human mammary carcinoma cell lines MCF-7 and T47D: Failure of cell-cell regulated exocytosis of apical membrane","volume":"54","author":"Vega-Salas","year":"1993","journal-title":"Differentiation"},{"key":"2023122621433976000_JOCES_108_5_1931C61","first-page":"L684","article-title":"Surfactant protein C: hormonal control of SP-C mRNA levels in vitro","volume":"262","author":"Veletza","year":"1992","journal-title":"Am. J. Physiol"},{"key":"2023122621433976000_JOCES_108_5_1931C62","first-page":"L431","article-title":"ATP and adenosine 3\u2019,5\u2019-cyclic monophosphate stimulate the synthesis of surfactant protein A in rat lung","volume":"264","author":"Wali","year":"1993","journal-title":"Am. J. Physiol"},{"key":"2023122621433976000_JOCES_108_5_1931C63","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1126\/science.1653455","article-title":"Regulation of kainate receptors by cAMP-dependent protein kinase and phosphatases","volume":"253","author":"Wang","year":"1991","journal-title":"Science"}],"container-title":["Journal of Cell Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.biologists.com\/jcs\/article-pdf\/108\/5\/1931\/3327185\/joces_108_5_1931.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/jcs\/article-pdf\/108\/5\/1931\/3327185\/joces_108_5_1931.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T21:44:05Z","timestamp":1703627045000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/jcs\/article\/108\/5\/1931\/24407\/Cyclic-AMP-modulates-the-rate-of-constitutive"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,5,1]]},"references-count":63,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1995,5,1]]}},"URL":"https:\/\/doi.org\/10.1242\/jcs.108.5.1931","relation":{},"ISSN":["0021-9533","1477-9137"],"issn-type":[{"value":"0021-9533","type":"print"},{"value":"1477-9137","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,5,1]]}}}