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The mouse submandibular salivary gland (SSG) served as model to assess the role of epidermal growth factor (EGF) receptor signaling during emergence of cell lineage diversity. Temporal fluctuations in EGF receptor mRNA levels coincident with crucial differentiative cell lineage transitions were revealed by RNase protection analyses. Between days 2 and 5, when proacinar cells are maturing and striated duct cells emerge, EGF receptor mRNA levels were highest and all differentiating cells exhibited EGF receptor immunoreactivity. EGF receptor mRNA levels then declined sharply and immunoreactivity became confined to ductal cells. At day 11 in male mice, and days 11 and 16 in females, a second increase in EGF receptor mRNA was detected coincident with emergence of granular convoluted tubule (GCT) cells. With completion of androgen-dependent GCT cell differentiation at the onset of puberty, EGF receptor mRNA levels and intensity of immunoreactivity decreased. Androgen effects on EGF receptor mRNA or immunoreactivity could not be detected. These temporally distinct patterns of EGF receptor expression suggest that this signaling pathway is a mechanism of potential importance in emergence of cell lineage diversity in a glandular organ.<\/jats:p>","DOI":"10.1242\/jcs.108.6.2205","type":"journal-article","created":{"date-parts":[[2021,4,25]],"date-time":"2021-04-25T16:27:10Z","timestamp":1619368030000},"page":"2205-2212","source":"Crossref","is-referenced-by-count":4,"title":["Emergence of salivary gland cell lineage diversity suggests a role for androgen-independent epidermal growth factor receptor signaling"],"prefix":"10.1242","volume":"108","author":[{"given":"Elisa M.","family":"Durban","sequence":"first","affiliation":[{"name":"The University of Texas-Houston Health Science Center 1 , Dental Branch, Division of Oral Pathology, Houston, Texas 77225-0068, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablito G.","family":"Nagpala","sequence":"additional","affiliation":[{"name":"The University of Texas-Houston Health Science Center 1 , Dental Branch, Division of Oral Pathology, Houston, Texas 77225-0068, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia D.","family":"Barreto","sequence":"additional","affiliation":[{"name":"The University of Texas-Houston Health Science Center 1 , Dental Branch, Division of Oral Pathology, Houston, Texas 77225-0068, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Egon","family":"Durban","sequence":"additional","affiliation":[{"name":"2 Baylor College of Medicine, Department of Pharmacology, Houston, Texas 77030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[1995,6,1]]},"reference":[{"key":"2023122621544176900_JOCES_108_6_2205C1","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/0012-1606(84)90007-1","article-title":"The ontogeny of epidermal growth factor receptors during mouse development","volume":"103","author":"Adamson","year":"1984","journal-title":"Dev. 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