{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T07:43:58Z","timestamp":1773733438326,"version":"3.50.1"},"reference-count":41,"publisher":"The Company of Biologists","issue":"2","license":[{"start":{"date-parts":[[1996,2,1]],"date-time":"1996-02-01T00:00:00Z","timestamp":823132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1996,2,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Contact of various cells with extracellular matrix molecules modulates their cellular functions and phenotype. Most investigations have employed dishes coated with purified matrix constituents or plain collagen I lattices omitting the effects of other important matrix components such as proteoglycans. In this study we analyze the effect of purified glycosaminoglycans (GAGs) on human fibroblasts and human umbilical vein endothelial cells (HUVEC) embedded within collagen I\/III lattices.<\/jats:p>\n               <jats:p>HUVEC contracted collagen I\/III gels far less efficiently than fibroblasts and addition of heparan sulfate and heparin almost completely inhibited contraction. In collagen gels HUVEC down-regulated collagenase mRNA while increasing collagen I, IV mRNA expression. Addition of heparin and heparan sulfate reversed the collagen IV mRNA induction whereas hyaluronic acid and chondroitin sulfate enhanced fibronectin and collagenase transcripts. Fibroblasts readily contracted collagen gels, and mRNA levels for fibronectin, collagenase and interleukin-6 were stimulated. Gel contraction was mostly unaffected by the different glycosaminoglycans. Fibroblasts responded to the addition of dermatan sulfate, heparan sulfate and heparin with a decrease in fibronectin, collagenase and interleukiN-6 mRNA. Binding studies revealed saturable binding sites on fibroblasts and HUVEC for 35S-labelled heparin, demonstrating specificity for heparin and heparan sulfate over other GAGs in competition experiments.<\/jats:p>\n               <jats:p>This study implies that glycosaminoglycans participate in cell-matrix interactions by effectively modulating the cellular phenotype via high affinity binding sites.<\/jats:p>","DOI":"10.1242\/jcs.109.2.479","type":"journal-article","created":{"date-parts":[[2021,4,25]],"date-time":"2021-04-25T12:33:30Z","timestamp":1619354010000},"page":"479-488","source":"Crossref","is-referenced-by-count":29,"title":["Glycosaminoglycans modulate cell-matrix interactions of human fibroblasts and endothelial cells in vitro"],"prefix":"10.1242","volume":"109","author":[{"given":"Thomas","family":"Schaefer","sequence":"first","affiliation":[{"name":"University of Cologne, Joseph-Stelzmann Strasse 9 1 Department of Dermatology , , 50924 Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Roux","sequence":"additional","affiliation":[{"name":"University of Cologne, Joseph-Stelzmann Strasse 9 1 Department of Dermatology , , 50924 Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helmut W.","family":"Stuhlsatz","sequence":"additional","affiliation":[{"name":"2 Department of Clinical Chemistry, Rheinisch Westf\u00e4lische Technische Hochschule, Pauwelstrasse 25, 52057 Aachen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rainer","family":"Herken","sequence":"additional","affiliation":[{"name":"Georg-August-Universit\u00e4t G\u00f6ttingen 3 Department of Anatomy , , Kreuzbergring 36, 37075 G\u00f6ttingen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"Coulomb","sequence":"additional","affiliation":[{"name":"4 INSERM, Unite 312, Laboratoire de Dermatologie, Hopital Henri Mondor, 94010 Creteil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Krieg","sequence":"additional","affiliation":[{"name":"University of Cologne, Joseph-Stelzmann Strasse 9 1 Department of Dermatology , , 50924 Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Smola","sequence":"additional","affiliation":[{"name":"University of Cologne, Joseph-Stelzmann Strasse 9 1 Department of Dermatology , , 50924 Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[1996,2,1]]},"reference":[{"key":"2023122623342493600_JOCES_109_2_479C1","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1073\/pnas.76.3.1274","article-title":"Production of a tissue-like structure by contraction of collagen lattices by human fibroblasts of different proliferative potential in vitro","volume":"76","author":"Bell","year":"1979","journal-title":"Proc. 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