{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T11:36:14Z","timestamp":1772537774121,"version":"3.50.1"},"reference-count":84,"publisher":"The Company of Biologists","issue":"19","license":[{"start":{"date-parts":[[1998,1,10]],"date-time":"1998-01-10T00:00:00Z","timestamp":884390400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1998,1,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Anosmin-1 is an extracellular matrix glycoprotein which underlies the X chromosome-linked form of Kallmann syndrome. This disease is characterized by hypogonadism due to GnRH deficiency, and a defective sense of smell related to the underdevelopment of the olfactory bulbs. This study reports that anosmin-1 is an adhesion molecule for a variety of neuronal and non-neuronal cell types in vitro. We show that cell adhesion to anosmin-1 is dependent on the presence of heparan sulfate and chondroitin sulfate glycosaminoglycans at the cell surface. A major cell adhesion site of anosmin-1 was identified in a 32 amino acid (32R1) sequence located within the first fibronectin-like type III repeat of the protein. The role of anosmin-1 as a substrate for neurite growth was tested on either coated culture dishes or monolayers of anosmin-1-producing CHO cells. In both experimental systems, anosmin-1 was shown to be a permissive substrate for the neurite growth of different types of neurons. Mouse P5 cerebellar neurons cultured on anosmin-1 coated wells developed long neurites; the 32R1 peptide was found to underly part of this neurite growth activity. When the cerebellar neurons were cultured on anosmin-1-producing CHO cells, neurite growth was reduced as compared to wild-type CHO cells; in contrast, no difference was observed for E18 hippocampal and P1 dorsal root ganglion neurons in the same experimental system. These results indicate that anosmin-1 can modulate neurite growth in a cell-type specific manner. Finally, anosmin-1 induced neurite fasciculation of P5 cerebellar neuron aggregates cultured on anosmin-1-producing CHO cells. The pathogenesis of the olfactory defect in the X-linked Kallmann syndrome is discussed in the light of the present results and the recent data reporting the immunohistochemical localisation of anosmin-1 during early embryonic development.<\/jats:p>","DOI":"10.1242\/jcs.111.19.2953","type":"journal-article","created":{"date-parts":[[2021,4,24]],"date-time":"2021-04-24T03:00:06Z","timestamp":1619233206000},"page":"2953-2965","source":"Crossref","is-referenced-by-count":76,"title":["Anosmin-1 underlying the X chromosome-linked Kallmann syndrome is an adhesion molecule that can modulate neurite growth in a cell-type specific manner"],"prefix":"10.1242","volume":"111","author":[{"given":"Nadia","family":"Soussi-Yanicostas","sequence":"first","affiliation":[{"name":"CNRS URA 1968, Institut Pasteur 1 Unit\u00e9 de G\u00e9n\u00e9tique des D\u00e9ficits Sensoriels , , 25 rue du Dr Roux, 75724 Paris Cedex 15, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Faivre-Sarrailh","sequence":"additional","affiliation":[{"name":"Laboratoire de G\u00e9n\u00e9tique et Physiologie du D\u00e9veloppement 2 , CNRS UMR 6545, Parc scientifique de Luminy, 13288 Marseille Cedex 09, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Pierre","family":"Hardelin","sequence":"additional","affiliation":[{"name":"CNRS URA 1968, Institut Pasteur 1 Unit\u00e9 de G\u00e9n\u00e9tique des D\u00e9ficits Sensoriels , , 25 rue du Dr Roux, 75724 Paris Cedex 15, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline","family":"Levilliers","sequence":"additional","affiliation":[{"name":"CNRS URA 1968, Institut Pasteur 1 Unit\u00e9 de G\u00e9n\u00e9tique des D\u00e9ficits Sensoriels , , 25 rue du Dr Roux, 75724 Paris Cedex 15, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Genevi\u00e8ve","family":"Rougon","sequence":"additional","affiliation":[{"name":"CNRS URA 1968, Institut Pasteur 1 Unit\u00e9 de G\u00e9n\u00e9tique des D\u00e9ficits Sensoriels , , 25 rue du Dr Roux, 75724 Paris Cedex 15, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Petit","sequence":"additional","affiliation":[{"name":"CNRS URA 1968, Institut Pasteur 1 Unit\u00e9 de G\u00e9n\u00e9tique des D\u00e9ficits Sensoriels , , 25 rue du Dr Roux, 75724 Paris Cedex 15, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[1998,1,10]]},"reference":[{"key":"2024010700350280300_JOCES_111_19_2953C1","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1038\/ng0297-157","article-title":"A human homologue of the Drosophila eyes absent gene underlies Branchio-Oto-Renal (BOR) syndrome and identifies a novel gene family","volume":"15","author":"Abdelhak","year":"1997","journal-title":"Nature Genet"},{"key":"2024010700350280300_JOCES_111_19_2953C2","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/0014-4827(89)90103-1","article-title":"Cell attachment properties of collagen type VI and Arg-Gly-Asp dependent binding to its alpha 2(VI) and alpha 3(VI) chains","volume":"181","author":"Aumailley","year":"1989","journal-title":"Exp. 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