{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:43:09Z","timestamp":1761061389218},"reference-count":52,"publisher":"The Company of Biologists","issue":"13","license":[{"start":{"date-parts":[[1999,7,1]],"date-time":"1999-07-01T00:00:00Z","timestamp":930787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999,7,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Mutations in presenilin 1 and 2 are causative factors for early onset familial Alzheimer\u2019s disease and possible roles for presenilins include protein trafficking, regulation of apoptosis and\/or calcium homeostasis. Presenilin 2 mRNA is expressed in brain, muscle and pancreas but the role of pancreatic presenilin 2 and its relationship to diabetes are unknown. Presenilin 2 immunoreactivity was localised in human and rodent pancreas to islet cells and found in granules of \u03b2-cells. Presenilin 2 was identified in primitive islet and duct cells of human foetal pancreas and in proliferating exocrine duct cells in human pancreatitis but not found in islet amyloid deposits in Type 2 diabetic subjects. Full length, \u223c50 kDa, and the \u223c30 kDa N-terminal fragment of presenilin 2 were identified by western blotting in extracted rodent pancreas but only the 30 kDa fragment was detected in mouse islets and human insulinoma. Post-mortem pancreatic morphology was normal in a subject with the presenilin 2 Met239Val variant and early onset familial Alzheimer\u2019s disease. Oral glucose tolerance tests on subjects with the presenilin 2 Met239Val mutation unaffected by early onset familial Alzheimer\u2019s disease (mean age 35 years) and on their first-degree relatives without the mutation demonstrated no evidence of glucose intolerance or increased proinsulin secretion. PS2 is a novel \u03b2-cell protein with potential roles in development or protein processing but pancreatic islet structure and function appear to be unaffected by the Met239Val mutation.<\/jats:p>","DOI":"10.1242\/jcs.112.13.2137","type":"journal-article","created":{"date-parts":[[2021,4,25]],"date-time":"2021-04-25T17:17:52Z","timestamp":1619371072000},"page":"2137-2144","source":"Crossref","is-referenced-by-count":4,"title":["Localisation of presenilin 2 in human and rodent pancreatic islet \u03b2-cells; Met239Val presenilin 2 variant is not associated with diabetes in man"],"prefix":"10.1242","volume":"112","author":[{"given":"Emma T. A. 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