{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T16:46:58Z","timestamp":1758905218471},"reference-count":58,"publisher":"The Company of Biologists","issue":"6","license":[{"start":{"date-parts":[[1999,3,15]],"date-time":"1999-03-15T00:00:00Z","timestamp":921456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999,3,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>FRT thyroid epithelial cells synthesize fibronectin and organize a network of fibronectin fibrils at the basal surface of the cells. Fibronectin fibril formation is enhanced by the overexpression of the ubiquitous \u03b21A integrin and is inhibited by the expression of the dominant-negative \u03b21B subunit. We tested the hypotheses that RhoA activity might mediate the integrin-dependent fibronectin fibrillogenesis and might counteract \u03b21B integrin inhibitory effect. FRT-\u03b21A cells were transfected with a vector carrying a dominant negative form of RhoA (RhoAN19) or treated with the C3 transferase exoenzyme. Both treatments inhibited fibronectin assembly and caused loss of actin microfilaments and adhesion plaques. On the other hand, FRT-\u03b21B cells were transfected with the constitutively activated form of RhoA (RhoAV14) or treated with the E. coli cytotoxic necrotizing factor 1, which directly activates RhoA. Either treatment restored microfilament and adhesion plaque assembly and promoted fibronectin fibril organization. A great increase in fibronectin fibril assembly was also obtained by treatment of FRT-\u03b21B cells with TGF-\u03b2.<\/jats:p>\n               <jats:p>Our data indicate that RhoA is required to promote fibronectin matrix assembly in FRT cells and that the activation of the signal transduction pathway downstream of RhoA can overcome the inhibitory effect of \u03b21B integrin.<\/jats:p>","DOI":"10.1242\/jcs.112.6.957","type":"journal-article","created":{"date-parts":[[2021,4,25]],"date-time":"2021-04-25T18:20:15Z","timestamp":1619374815000},"page":"957-965","source":"Crossref","is-referenced-by-count":19,"title":["RhoA activity is required for fibronectin assembly and counteracts \u03b21B integrin inhibitory effect in FRT epithelial cells"],"prefix":"10.1242","volume":"112","author":[{"given":"Gaetano","family":"Cal\u00ec","sequence":"first","affiliation":[{"name":"Universit\u00e0 degli Studi di Napoli \u2018Federico II\u2019 1 Centro di Endocrinologia ed Oncologia Sperimentale del CNR \u2013 Dipartimento di Biologia e Patologia Cellulare e Molecolare , , Napoli, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Mazzarella","sequence":"additional","affiliation":[{"name":"Universit\u00e0 degli Studi di Napoli \u2018Federico II\u2019 1 Centro di Endocrinologia ed Oncologia Sperimentale del CNR \u2013 Dipartimento di Biologia e Patologia Cellulare e Molecolare , , Napoli, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianna","family":"Chiacchio","sequence":"additional","affiliation":[{"name":"Universit\u00e0 degli Studi di Napoli \u2018Federico II\u2019 1 Centro di Endocrinologia ed Oncologia Sperimentale del CNR \u2013 Dipartimento di Biologia e Patologia Cellulare e Molecolare , , Napoli, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa","family":"Negri","sequence":"additional","affiliation":[{"name":"Universit\u00e0 degli Studi di Napoli \u2018Federico II\u2019 1 Centro di Endocrinologia ed Oncologia Sperimentale del CNR \u2013 Dipartimento di Biologia e Patologia Cellulare e Molecolare , , Napoli, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saverio Francesco","family":"Retta","sequence":"additional","affiliation":[{"name":"2 Istituto di Biologia, Facolt\u00e0 di Medicina e Chirurgia, Universit\u00e0 degli Studi di Palermo, Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariastella","family":"Zannini","sequence":"additional","affiliation":[{"name":"Universit\u00e0 degli Studi di Napoli \u2018Federico II\u2019 1 Centro di Endocrinologia ed Oncologia Sperimentale del CNR \u2013 Dipartimento di Biologia e Patologia Cellulare e Molecolare , , Napoli, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flaviana","family":"Gentile","sequence":"additional","affiliation":[{"name":"Universit\u00e0 degli Studi di Napoli \u2018Federico II\u2019 1 Centro di Endocrinologia ed Oncologia Sperimentale del CNR \u2013 Dipartimento di Biologia e Patologia Cellulare e Molecolare , , Napoli, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido","family":"Tarone","sequence":"additional","affiliation":[{"name":"Universit\u00e0 degli Studi di Torino 3 Dipartimento di Genetica, Biologia e Chimica Medica , , Torino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucio","family":"Nitsch","sequence":"additional","affiliation":[{"name":"Universit\u00e0 degli Studi di Napoli \u2018Federico II\u2019 1 Centro di Endocrinologia ed Oncologia Sperimentale del CNR \u2013 Dipartimento di Biologia e Patologia Cellulare e Molecolare , , Napoli, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corrado","family":"Garbi","sequence":"additional","affiliation":[{"name":"Universit\u00e0 degli Studi di Napoli \u2018Federico II\u2019 1 Centro di Endocrinologia ed Oncologia Sperimentale del CNR \u2013 Dipartimento di Biologia e Patologia Cellulare e Molecolare , , Napoli, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[1999,3,15]]},"reference":[{"key":"2024011223011963200_JOCES_112_6_957C1","doi-asserted-by":"publisher","first-page":"27863","DOI":"10.1016\/S0021-9258(18)46866-4","article-title":"Fibronectin self-association is mediated by complementary sites within the amino-terminal one-third of the molecule","volume":"269","author":"Aguirre","year":"1994","journal-title":"J. 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