{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:09:01Z","timestamp":1791227341090,"version":"4.1.0"},"reference-count":57,"publisher":"The Company of Biologists","issue":"21","license":[{"start":{"date-parts":[[2000,11,1]],"date-time":"2000-11-01T00:00:00Z","timestamp":973036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,11,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Septins have been shown to play important roles in cytokinesis in diverse organisms ranging from yeast to mammals. In this study, we show that both the unc-59 and unc-61 loci encode Caenorhabditis elegans septins. Genomic database searches indicate that unc-59 and unc-61 are probably the only septin genes in the C. elegans genome. UNC-59 and UNC-61 localize to the leading edge of cleavage furrows and eventually reside at the midbody. Analysis of unc-59 and unc-61 mutants revealed that each septin requires the presence of the other for localization to the cytokinetic furrow. Surprisingly, unc-59 and unc-61 mutants generally have normal embryonic development; however, defects were observed in post-embryonic development affecting the morphogenesis of the vulva, male tail, gonad, and sensory neurons. These defects can be at least partially attributed to failures in post-embryonic cytokineses although our data also suggest other possible roles for septins. unc-59 and unc-61 double mutants show similar defects to each of the single mutants.<\/jats:p>","DOI":"10.1242\/jcs.113.21.3825","type":"journal-article","created":{"date-parts":[[2021,4,25]],"date-time":"2021-04-25T18:34:07Z","timestamp":1619375647000},"page":"3825-3837","source":"Crossref","is-referenced-by-count":117,"title":["The <i>C. elegans<\/i> septin genes, <i>unc-59<\/i> and <i>unc-61<\/i>, are required for normal postembryonic cytokineses and morphogenesis but have no essential function in embryogenesis"],"prefix":"10.1242","volume":"113","author":[{"given":"Tri Q.","family":"Nguyen","sequence":"first","affiliation":[{"name":"University of Wisconsin 1 Cellular Molecular Biology Program, Laboratory of Molecular Biology , , Madison, WI 53706 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Sawa","sequence":"additional","affiliation":[{"name":"Osaka University Graduate School of Medicine 2 Division of Neuroanatomy , , Suita, Osaka 565-0871, Japan"},{"name":"3 PRESTO, JST"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideyuki","family":"Okano","sequence":"additional","affiliation":[{"name":"Osaka University Graduate School of Medicine 2 Division of Neuroanatomy , , Suita, Osaka 565-0871, Japan"},{"name":"4 CREST, JST"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G.","family":"White","sequence":"additional","affiliation":[{"name":"University of Wisconsin 1 Cellular Molecular Biology Program, Laboratory of Molecular Biology , , Madison, WI 53706 USA"},{"name":"University of Wisconsin-Madison 5 Department of Anatomy , , WI 53706 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2000,11,1]]},"reference":[{"key":"2024011400113376400_JOCES_113_21_3825C1","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/0012-1606(84)90117-9","article-title":"Formation of the first cleavage spindle in nematode embryos","volume":"101","author":"Albertson","year":"1984","journal-title":"Dev. 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