{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T02:16:31Z","timestamp":1791425791362,"version":"4.3.3"},"reference-count":61,"publisher":"The Company of Biologists","issue":"1","license":[{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"vor","delay-in-days":181,"URL":"http:\/\/www.biologists.com\/user-licence-1-1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,1,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The formation of the larval body wall musculature of Drosophila depends on the asymmetric fusion of two myoblast types, founder cells (FCs) and fusion-competent myoblasts (FCMs). Recent studies have established an essential function of Arp2\/3-based actin polymerization during myoblast fusion, formation of a dense actin focus at the site of fusion in FCMs, and a thin sheath of actin in FCs and\/or growing muscles. The formation of these actin structures depends on recognition and adhesion of myoblasts that is mediated by cell surface receptors of the immunoglobulin superfamily. However, the connection of the cell surface receptors with Arp2\/3-based actin polymerization is poorly understood. To date only the SH2-SH3 adaptor protein Crk has been suggested to link cell adhesion with Arp2\/3-based actin polymerization in FCMs. Here, we propose that the SH2-SH3 adaptor protein Dock, like Crk, links cell adhesion with actin polymerization. We show that Dock is expressed in FCs and FCMs and colocalizes with the cell adhesion proteins Sns and Duf at cell\u2013cell contact points. Biochemical data in this study indicate that different domains of Dock are involved in binding the cell adhesion molecules Duf, Rst, Sns and Hbs. We emphasize the importance of these interactions by quantifying the enhanced myoblast fusion defects in duf dock, sns dock and hbs dock double mutants. Additionally, we show that Dock interacts biochemically and genetically with Drosophila Scar, Vrp1 and WASp. Based on these data, we propose that Dock links cell adhesion in FCs and FCMs with either Scar\u2013 or Vrp1\u2013WASp-dependent Arp2\/3 activation.<\/jats:p>","DOI":"10.1242\/jcs.113860","type":"journal-article","created":{"date-parts":[[2012,9,20]],"date-time":"2012-09-20T00:56:26Z","timestamp":1348102586000},"page":"360-372","source":"Crossref","is-referenced-by-count":39,"title":["Dock mediates Scar- and WASp-dependent actin polymerization through interaction with cell adhesion molecules in founder cells and fusion-competent myoblasts"],"prefix":"10.1242","volume":"126","author":[{"given":"Balasankara Reddy","family":"Kaipa","sequence":"first","affiliation":[{"name":"Fachbereich Biologie, Entwicklungsbiologie, Philipps-Universit\u00e4t Marburg, Karl-von-Frisch Str. 8, D-35043 Marburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanjie","family":"Shao","sequence":"additional","affiliation":[{"name":"Stowers Institute for Medical Research, Kansas City, MO 64110, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gritt","family":"Sch\u00e4fer","sequence":"additional","affiliation":[{"name":"Fachbereich Biologie, Entwicklungsbiologie, Philipps-Universit\u00e4t Marburg, Karl-von-Frisch Str. 8, D-35043 Marburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatjana","family":"Trinkewitz","sequence":"additional","affiliation":[{"name":"Fachbereich Biologie, Entwicklungsbiologie, Philipps-Universit\u00e4t Marburg, Karl-von-Frisch Str. 8, D-35043 Marburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena","family":"Groth","sequence":"additional","affiliation":[{"name":"Fachbereich Biologie, Entwicklungsbiologie, Philipps-Universit\u00e4t Marburg, Karl-von-Frisch Str. 8, D-35043 Marburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianqi","family":"Liu","sequence":"additional","affiliation":[{"name":"Stowers Institute for Medical Research, Kansas City, MO 64110, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lothar","family":"Beck","sequence":"additional","affiliation":[{"name":"Fachbereich Biologie, Spezielle Zoologie, Philipps-Universit\u00e4t Marburg, Karl-von-Frisch Str. 8, D-35043 Marburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Bogdan","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Neurobiologie, Badestr. 9, 48149 M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M.","family":"Abmayr","sequence":"additional","affiliation":[{"name":"Stowers Institute for Medical Research, Kansas City, MO 64110, USA"},{"name":"Department of Anatomy and Cell Biology, University of Kansas School of Medicine, Kansas City, KS 66160, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne-Filiz","family":"\u00d6nel","sequence":"additional","affiliation":[{"name":"Fachbereich Biologie, Entwicklungsbiologie, Philipps-Universit\u00e4t Marburg, Karl-von-Frisch Str. 8, D-35043 Marburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021111216292304000_b1","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1242\/dev.068353","article-title":"Myoblast fusion: lessons from flies and mice.","volume":"139","author":"Abmayr","year":"2012","journal-title":"Development"},{"key":"2021111216292304000_b2","doi-asserted-by":"publisher","first-page":"20992","DOI":"10.1074\/jbc.273.33.20992","article-title":"The Wiskott-Aldrich syndrome protein-interacting protein (WIP) binds to the adaptor protein Nck.","volume":"273","author":"Ant\u00f3n","year":"1998","journal-title":"J. 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