{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:39:30Z","timestamp":1792089570573,"version":"4.4.0"},"reference-count":51,"publisher":"The Company of Biologists","issue":"24","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,12,15]]},"abstract":"<jats:p>Nuclear lamin A and C alleles that are linked to three distinct human diseases have been expressed both in HeLa cells and in fibroblasts derived from Lmna null mice. Point mutations that cause dilated cardiomyopathy (L85R and N195K) and autosomal dominant Emery-Dreifuss muscular dystrophy (L530P) modify the assembly properties of lamins A and C and cause partial mislocalization of emerin, an inner nuclear membrane protein, in HeLa cells. At the same time, these mutant lamins interfere with the targeting and assembly of endogenous lamins and in this way may cause significant changes in the molecular organization of the nuclear periphery. By contrast, lamin A and C molecules harboring a point mutation (R482W), which gives rise to a dominant form of familial partial lipodystrophy, behave in a manner that is indistinguishable from wild-type lamins A and C, at least with respect to targeting and assembly within the nuclear lamina. Taken together, these results suggest that nuclear structural defects could contribute to the etiology of both dilated cardiomyopathy and autosomal dominant Emery-Dreifuss muscular dystrophy.<\/jats:p>","DOI":"10.1242\/jcs.114.24.4447","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T00:33:31Z","timestamp":1619397211000},"page":"4447-4457","source":"Crossref","is-referenced-by-count":187,"title":["Nuclear envelope defects associated with<i>LMNA<\/i>mutations cause dilated cardiomyopathy and Emery-Dreifuss muscular dystrophy"],"prefix":"10.1242","volume":"114","author":[{"given":"Wahyu Hendrati","family":"Raharjo","sequence":"first","affiliation":[{"name":"Department of Cell Biology and Anatomy, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Enarson","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Anatomy, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Laboratory of Cancer and Developmental Biology, NCI-FCRDC, PO Box B, Frederick, MD 21702-1201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin L.","family":"Stewart","sequence":"additional","affiliation":[{"name":"Laboratory of Cancer and Developmental Biology, NCI-FCRDC, PO Box B, Frederick, MD 21702-1201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Burke","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Anatomy, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada"},{"name":"Present address: Department of Anatomy and Cell Biology, University of Florida, Box 100235, Gainesville, FL 32610, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042600083650500_ASH-ETAL-1977","doi-asserted-by":"crossref","unstructured":"Ash, J. 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