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This correlation between integrin activation and raft localisation extends to a second integrin,\u03b14\u03b21, and the clustering of \u03b14\u03b21 is also raft dependent. Both LFA-1 and \u03b14\u03b21-mediated adhesion is dependent upon intact lipid rafts providing proof of the functional relevance of the lipid raft localisation. Finally we find that non-raft integrins are excluded from the rafts by cytoskeletal constraints. The presence of integrin in lipid rafts under stimulating conditions that activate these receptors strongly indicates that the rafts have a key role in positively regulating integrin activity.<\/jats:p>","DOI":"10.1242\/jcs.115.5.963","type":"journal-article","created":{"date-parts":[[2021,4,24]],"date-time":"2021-04-24T03:32:23Z","timestamp":1619235143000},"page":"963-972","source":"Crossref","is-referenced-by-count":264,"title":["The involvement of lipid rafts in the regulation of integrin function"],"prefix":"10.1242","volume":"115","author":[{"given":"Birgit","family":"Leitinger","sequence":"first","affiliation":[{"name":"Leukocyte Adhesion Laboratory, Imperial Cancer Research Fund, London, WC2A 3PX, UK"},{"name":"Sackler Institute for Muscular Skeletal Research, Department of Medicine,University College London, 5 University Street, London, WC1E 6JJ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Hogg","sequence":"additional","affiliation":[{"name":"Leukocyte Adhesion Laboratory, Imperial Cancer Research Fund, London, WC2A 3PX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042517364102100_REF1","doi-asserted-by":"crossref","unstructured":"Blystone, S. 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